Browsing HMS Scholarly Articles by Title
Now showing items 16820-16839 of 17922
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TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation
(Public Library of Science, 2015)The Epstein-Barr virus (EBV) encoded oncoprotein Latent Membrane Protein 1 (LMP1) signals through two C-terminal tail domains to drive cell growth, survival and transformation. The LMP1 membrane-proximal TES1/CTAR1 domain ... -
A TRAF2 binding independent region of TNFR2 is responsibl for TRAF2 depletion and enhancement of cytotoxicity driven b TNFR1
(Impact Journals LLC, 2014)Tumor Necrosis Factor (TNF) interacts with two receptors known as TNFR1 and TNFR2. TNFR1 activation may result in either cell proliferation or cell death. TNFR2 activates Nuclear Factor-kappaB (NF-kB) and c-Jun N-terminal ... -
TRAF2 is an NF-κB activating oncogene in epithelial cancers
(2014)Aberrant NF-κB activation is frequently observed in human cancers. Genome characterization efforts have identified genetic alterations in multiple components of the NF-κB pathway, some of which have been shown to be essential ... -
Traffic-related exposures and biomarkers of systemic inflammation, endothelial activation and oxidative stress: a panel study in the US trucking industry
(BioMed Central, 2013)Background: Experimental evidence suggests that inhaled particles from vehicle exhaust have systemic effects on inflammation, endothelial activation and oxidative stress. In the present study we assess the relationships ... -
TRAIL Enhances Apoptosis of Human Hepatocellular Carcinoma Cells Sensitized by Hepatitis C Virus Infection: Therapeutic Implications
(Public Library of Science, 2014)Hepatitis C virus (HCV) infection causes chronic liver diseases leading to hepatocellular carcinoma (HCC) and liver failure. We have previously shown that HCV sensitizes hepatocytes to mitochondrial apoptosis via the TRAIL ... -
Training dual-task walking in community-dwelling adults within 1 year of stroke: A protocol for a single-blind randomized controlled trial
(BioMed Central, 2012)Background: Community ambulation is a highly complex skill requiring the ability to adapt to increased environmental complexity and perform multiple tasks simultaneously. After stroke, individuals demonstrate a diminished ... -
Training in Childhood Obesity Management in the United States: A Survey of Pediatric, Internal Medicine-pediatrics and Family Medicine Residency Program Directors
(BioMed Central, 2010)Background: Information about the availability and effectiveness of childhood obesity training during residency is limited. Methods: We surveyed residency program directors from pediatric, internal medicine-pediatrics ... -
Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli
(Public Library of Science, 2011)Predictive understanding of cell signaling network operation based on general prior knowledge but consistent with empirical data in a specific environmental context is a current challenge in computational biology. Recent ... -
Training the Future Leaders in Personalized Medicine
(MDPI, 2016)The era of personalized medicine has arrived, and with it a need for leaders in this discipline. This generation of trainees requires a cadre of new skill sets to lead the implementation of personalized medicine into ... -
Training the Machine Learning Programs to Measure the Arterial Phase and Identify the Types of Coronary Flow
(Tan Tao University, 2022-10-09)Coronary artery disease (CAD) is one of the most common and severe medical conditions worldwide. The current research focused on investigating the mechanisms and prevention of the detrimental effects of CAD. Recently, the ... -
TRAIP is a master regulator of DNA interstrand crosslink repair
(Springer Nature, 2019-03)Cells often utilize multiple pathways to repair the same DNA lesion, and pathway choice has profound implications for the fidelity of genome maintenance. DNA interstrand cross-links (ICLs) block DNA replication and ... -
Trajectories of length, weight, and bone mineral density among preterm infants during the first 12 months of corrected age in China
(BioMed Central, 2015)Background: Limited evidence has been provided on the trajectories of length, weight, and bone mineral density (BMD) among preterm infants in early life in Asian countries. Methods: We conducted a longitudinal study, which ... -
Trajectories of Objectively Measured Physical Activity in Free-Living Older Men
(Lippincott Williams & Wilkins, 2015)ABSTRACT Background: The steep decline in physical activity (PA) among the oldest old is not well understood; there is little information about the patterns of change in PA and sedentary behaviour (SB) in older people. ... -
Trajectories of risk after hospitalization for heart failure, acute myocardial infarction, or pneumonia: retrospective cohort study
(BMJ Publishing Group Ltd., 2015)Objective: To characterize the absolute risks for older patients of readmission to hospital and death in the year after hospitalization for heart failure, acute myocardial infarction, or pneumonia. Design: Retrospective ... -
Trans Fatty Acids in European Margarines
(New England Journal of Medicine (NEJM/MMS), 1995) -
trans-Fatty Acid Isomers in Adipose Tissue Have Divergent Associations with Adiposity in Humans
(Springer-Verlag, 2010)The aim of this study was to evaluate the association between adipose tissue trans-fatty acid isomers and adiposity. This cross-sectional study included 1,785 subjects from Costa Rica. Fatty acid concentrations (as a ... -
Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine
(The Rockefeller University Press, 2014)Dendritic cells (DCs) are well established as potent antigen-presenting cells critical to adaptive immunity. In vaccination approaches, appropriately stimulating lymph node–resident DCs (LNDCs) is highly relevant to effective ... -
Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci
(Wolters Kluwer, 2016)Objective: Given evidence from genetic studies, we hypothesized that there may be a shared component to the role of myeloid function in Parkinson and Alzheimer disease (PD and AD) and assessed whether PD susceptibility ... -
Transactivation of human osteoprotegerin promoter by GATA-3
(Nature Publishing Group, 2015)Osteoprotegerin (OPG) is a key regulator of bone remodeling. Mutations in OPG are involved in a variety of human diseases. We have shown that cochlear spiral ganglion cells secrete OPG at high levels and lack of OPG causes ...