Browsing HMS Scholarly Articles by Title

Now showing items 1706-1725 of 17920

    • Biology of breast cancer in young women 

      Azim, Hatem A; Partridge, Ann H (BioMed Central, 2014)
      Breast cancer arising at a young age is relatively uncommon, particularly in the developed world. Several studies have demonstrated that younger patients often experience a more aggressive disease course and have poorer ...

    • The Biology of Retinopathy of Prematurity 

      Smith, Lois Elaine Hodgson; Hard, Anna-Lena; Hellström, Ann (Elsevier BV, 2013)
      Retinopathy of prematurity occurs because the retina of a preterm infant at birth is incompletely vascularized, and if the postnatal environment does not match the in utero environment that supported retinal development, ...

    • Bioluminescence Imaging Reveals Inhibition of Tumor Cell Proliferation by Alzheimer's Amyloid β Protein 

      Cui, Kemi; O'Brien, Megan; Wong, Kelvin K; Kesari, Santosh; Wong, Stephen TC; Zhao, Hong; Zhu, Jinmin; Xu, Xiaoyin; Xia, Weiming (BioMed Central, 2009)
      Background: Cancer and Alzheimer's disease (AD) are two seemingly distinct diseases and rarely occur simultaneously in patients. To explore molecular determinants differentiating pathogenic routes towards AD or cancer, we ...

    • Bioluminescence-Activated Deep-Tissue Photodynamic Therapy of Cancer 

      Kim, Yi Rang; Kim, Seonghoon; Choi, Jin Woo; Choi, Sung Yong; Lee, Sang-Hee; Kim, Homin; Hahn, Sei Kwang; Koh, Gou Young; Yun, Seok Hyun (Ivyspring International Publisher, 2015)
      Optical energy can trigger a variety of photochemical processes useful for therapies. Owing to the shallow penetration of light in tissues, however, the clinical applications of light-activated therapies have been limited. ...

    • Bioluminescence-mediated longitudinal monitoring of adipose-derived stem cells in a large mammal ex vivo organ culture 

      Peeters, Mirte; van Rijn, Sjoerd; Paul, Cornelis P. L.; Vergroesen, Pieter-Paul A.; Noske, David P.; Peter Vandertop, W.; Wurdinger, Thomas; Helder, Marco N. (Nature Publishing Group, 2015)
      Recently, ex vivo three-dimensional organ culture systems have emerged to study the physiology and pathophysiology of human organs. These systems also have potential as a translational tool in tissue engineering; however, ...

    • BiomarCaRE: rationale and design of the European BiomarCaRE project including 300,000 participants from 13 European countries 

      Zeller, Tanja; Hughes, Maria; Tuovinen, Tarja; Schillert, Arne; Conrads-Frank, Annette; Ruijter, Hester den; Schnabel, Renate B.; Kee, Frank; Salomaa, Veikko; Siebert, Uwe; Thorand, Barbara; Ziegler, Andreas; Breek, Heico; Pasterkamp, Gerard; Kuulasmaa, Kari; Koenig, Wolfgang; Blankenberg, Stefan (Springer Netherlands, 2014)
      Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and ...

    • Biomarker analyses in REGARD gastric/GEJ carcinoma patients treated with VEGFR2-targeted antibody ramucirumab 

      Fuchs, Charles S; Tabernero, Josep; Tomášek, Jiří; Chau, Ian; Melichar, Bohuslav; Safran, Howard; Tehfe, Mustapha A; Filip, Dumitru; Topuzov, Eldar; Schlittler, Luis; Udrea, Anghel Adrian; Campbell, William; Brincat, Stephen; Emig, Michael; Melemed, Symantha A; Hozak, Rebecca R; Ferry, David; Caldwell, C William; Ajani, Jaffer A (Nature Publishing Group, 2016)
      Background: Angiogenesis inhibition is an important strategy for cancer treatment. Ramucirumab, a human IgG1 monoclonal antibody that targets VEGF receptor 2 (VEGFR2), inhibits VEGF-A, -C, -D binding and endothelial cell ...

    • Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons 

      Fischer, Krista; Kettunen, Johannes; Würtz, Peter; Haller, Toomas; Havulinna, Aki S.; Kangas, Antti J.; Soininen, Pasi; Esko, Tõnu; Tammesoo, Mari-Liis; Mägi, Reedik; Smit, Steven; Palotie, Aarno; Ripatti, Samuli; Salomaa, Veikko; Ala-Korpela, Mika; Perola, Markus; Metspalu, Andres (Public Library of Science, 2014)
      Background: Early identification of ambulatory persons at high short-term risk of death could benefit targeted prevention. To identify biomarkers for all-cause mortality and enhance risk prediction, we conducted high-throughput ...

    • Biomarker Validation of Dietary Intervention in Two Multiethnic Populations 

      Eliassen, A Heather; Colditz, Graham A.; Peterson, Karen E.; Furtado, Jeremy Daniel; Fay, Martha Elizabeth; Sorensen, Glorian; Emmons, Karen Maria (Centers for Disease Control and Prevention, 2006)
      Introduction: Intervention studies have been designed to change dietary and lifestyle factors associated with chronic diseases, but self-reported behavior change may incorporate intervention-related bias. This study examines ...

    • Biomarker-based prediction of progression in MCI: Comparison of AD signature and hippocampal volume with spinal fluid amyloid-β and tau 

      Dickerson, Bradford C.; Wolk, David A. (Frontiers Media S.A., 2013)
      Objective: New diagnostic criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) have been developed using biomarkers aiming to establish whether the clinical syndrome is likely due to underlying AD. ...

    • Biomarker-Defined Subsets of Common Diseases: Policy and Economic Implications of Orphan Drug Act Coverage 

      Kesselheim, Aaron S.; Treasure, Carolyn L.; Joffe, Steven (Public Library of Science, 2017)
      Aaron Kesselheim and colleagues examine orphan-designated drugs approved between 2009 and 2015 in the United States.

    • Biomarkers for Identifying First-Episode Schizophrenia Patients Using Diffusion Weighted Imaging 

      Rathi, Yogesh; Malcolm, James; Michailovich, Oleg; Goldstein, Jill M.; Seidman, Larry Joel; McCarley, Robert William; Westin, Carl-Fredrik; Shenton, Martha Elizabeth (Springer Science + Business Media, 2010)
      Recent advances in diffusion weighted MR imaging (dMRI) has made it a tool of choice for investigating white matter abnormalities of the brain and central nervous system. In this work, we design a system that detects ...

    • Biomarkers of Dairy Fatty Acids and Risk of Cardiovascular Disease in the Multi‐Ethnic Study of Atherosclerosis 

      de Oliveira Otto, Marcia C.; Nettleton, Jennifer A.; Lemaitre, Rozenn N.; M. Steffen, Lyn; Kromhout, Daan; Rich, Stephen S.; Y. Tsai, Michael; Jacobs, David R.; Mozaffarian, Dariush (Blackwell Publishing Ltd, 2013)
      Background: Evidence regarding the role of dairy fat intake in cardiovascular disease (CVD) has been mixed and inconclusive. Most earlier studies have used self‐reported measures of dietary intake and focused on relatively ...

    • Biomarkers of Environmental Enteropathy are Positively Associated with Immune Responses to an Oral Cholera Vaccine in Bangladeshi Children 

      Uddin, Muhammad Ikhtear; Islam, Shahidul; Nishat, Naoshin S.; Hossain, Motaher; Rafique, Tanzeem Ahmed; Rashu, Rasheduzzaman; Hoq, Mohammad Rubel; Zhang, Yue; Saha, Amit; Harris, Jason B.; Calderwood, Stephen B.; Bhuiyan, Taufiqur Rahman; Ryan, Edward T.; Leung, Daniel T.; Qadri, Firdausi (Public Library of Science, 2016)
      Environmental enteropathy (EE) is a poorly understood condition that refers to chronic alterations in intestinal permeability, absorption, and inflammation, which mainly affects young children in resource-limited settings. ...

    • Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil 

      Guerrant, Richard L.; Leite, Alvaro M.; Pinkerton, Relana; Medeiros, Pedro H. Q. S.; Cavalcante, Paloma A.; DeBoer, Mark; Kosek, Margaret; Duggan, Christopher; Gewirtz, Andrew; Kagan, Jonathan C.; Gauthier, Anna E.; Swann, Jonathan; Mayneris-Perxachs, Jordi; Bolick, David T.; Maier, Elizabeth A.; Guedes, Marjorie M.; Moore, Sean R.; Petri, William A.; Havt, Alexandre; Lima, Ila F.; Prata, Mara de Moura Gondim; Michaleckyj, Josyf C.; Scharf, Rebecca J.; Sturgeon, Craig; Fasano, Alessio; Lima, Aldo A. M. (Public Library of Science, 2016)
      Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and ...

    • The biomarkers of immune dysregulation and inflammation response in Parkinson disease 

      Chen, Li; Mo, Mingshu; Li, Guangning; Cen, Luan; Wei, Lei; Xiao, Yousheng; Chen, Xiang; Li, Shaomin; Yang, Xinling; Qu, Shaogang; Xu, Pingyi (BioMed Central, 2016)
      Parkinson’s disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histocompatibility ...

    • Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons 

      Bollati, Valentina; Tarantini, Letizia; Hu, Howard; Schwartz, Joel David; Wright, Rosalind Jo; Park, Sung Kyun; Sparrow, David; Vokonas, Pantel S; Baccarelli, Andrea; Wright, Robert O. (National Institute of Environmental Health Sciences, 2010)
      Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ...

    • Biomarkers of Sarcopenia in Clinical Trials—Recommendations from the International Working Group on Sarcopenia 

      Cesari, Matteo; Pahor, Marco; Goodpaster, Bret; Hellerstein, Marc; Van Kan, Gabor A.; Anker, Stefan D.; Vrijbloed, J. Willem; Isaac, Maria; Rolland, Yves; M’Rini, Christine; Aubertin-Leheudre, Mylène; Cedarbaum, Jesse M.; Zamboni, Mauro; Sieber, Cornell C.; Laurent, Didier; Evans, William J.; Roubenoff, Ronenn; Morley, John E.; Vellas, Bruno; Fielding, Roger Arthur; Rutkove, Seward Brian (Springer-Verlag, 2012)
      Sarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons. The study of this phenomenon and the development of preventive/therapeutic ...

    • Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases 

      Metcalfe, Dean D.; Pawankar, Ruby; Ackerman, Steven J.; Akin, Cem; Clayton, Frederic; Falcone, Franco H.; Gleich, Gerald J.; Irani, Anne-Marie; Johansson, Mats W.; Klion, Amy D.; Leiferman, Kristin M.; Levi-Schaffer, Francesca; Nilsson, Gunnar; Okayama, Yoshimichi; Prussin, Calman; Schroeder, John T.; Schwartz, Lawrence B.; Simon, Hans-Uwe; Walls, Andrew F.; Triggiani, Massimo (BioMed Central, 2016)
      Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic ...

    • Biomarkers: A Challenging Conundrum in Cardiovascular Disease 

      Libby, Peter; King, Kevin Robert (Ovid Technologies (Wolters Kluwer Health), 2015)
      The use of biomarkers has proven utility in cardiovascular medicine and holds great promise for future advances, but their application requires considerable rigor in thinking and methodology. Numerous confounding factors ...