Browsing HMS Scholarly Articles by Title
Now showing items 1715-1734 of 17918
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Biomarker-based prediction of progression in MCI: Comparison of AD signature and hippocampal volume with spinal fluid amyloid-β and tau
(Frontiers Media S.A., 2013)Objective: New diagnostic criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) have been developed using biomarkers aiming to establish whether the clinical syndrome is likely due to underlying AD. ... -
Biomarker-Defined Subsets of Common Diseases: Policy and Economic Implications of Orphan Drug Act Coverage
(Public Library of Science, 2017)Aaron Kesselheim and colleagues examine orphan-designated drugs approved between 2009 and 2015 in the United States. -
Biomarkers for Identifying First-Episode Schizophrenia Patients Using Diffusion Weighted Imaging
(Springer Science + Business Media, 2010)Recent advances in diffusion weighted MR imaging (dMRI) has made it a tool of choice for investigating white matter abnormalities of the brain and central nervous system. In this work, we design a system that detects ... -
Biomarkers of Dairy Fatty Acids and Risk of Cardiovascular Disease in the Multi‐Ethnic Study of Atherosclerosis
(Blackwell Publishing Ltd, 2013)Background: Evidence regarding the role of dairy fat intake in cardiovascular disease (CVD) has been mixed and inconclusive. Most earlier studies have used self‐reported measures of dietary intake and focused on relatively ... -
Biomarkers of Environmental Enteropathy are Positively Associated with Immune Responses to an Oral Cholera Vaccine in Bangladeshi Children
(Public Library of Science, 2016)Environmental enteropathy (EE) is a poorly understood condition that refers to chronic alterations in intestinal permeability, absorption, and inflammation, which mainly affects young children in resource-limited settings. ... -
Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil
(Public Library of Science, 2016)Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and ... -
The biomarkers of immune dysregulation and inflammation response in Parkinson disease
(BioMed Central, 2016)Parkinson’s disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histocompatibility ... -
Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons
(National Institute of Environmental Health Sciences, 2010)Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ... -
Biomarkers of Sarcopenia in Clinical Trials—Recommendations from the International Working Group on Sarcopenia
(Springer-Verlag, 2012)Sarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons. The study of this phenomenon and the development of preventive/therapeutic ... -
Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases
(BioMed Central, 2016)Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic ... -
Biomarkers: A Challenging Conundrum in Cardiovascular Disease
(Ovid Technologies (Wolters Kluwer Health), 2015)The use of biomarkers has proven utility in cardiovascular medicine and holds great promise for future advances, but their application requires considerable rigor in thinking and methodology. Numerous confounding factors ... -
Biomarkers: the next therapeutic hurdle in metastatic renal cell carcinoma
(Nature Publishing Group, 2012)Despite recent advances, metastatic renal cell carcinoma remains largely an incurable disease. Vascular endothelial growth factor and mammalian target of rapamycin inhibitors have provided improvements in clinical outcomes. ... -
Biomaterials and emerging anticancer therapeutics: engineering the microenvironment
(Nature Publishing Group, 2015)The microenvironment is increasingly recognized to have key roles in cancer, and biomaterials provide a means to engineer microenvironments both in vitro and in vivo to study and manipulate cancer. In vitro cancer models ... -
Biomechanical Considerations in the Pathogenesis of Osteoarthritis of the Knee
(Springer-Verlag, 2011)Osteoarthritis is the most common joint disease and a major cause of disability. The knee is the large joint most affected. While chronological age is the single most important risk factor of osteoarthritis, the pathogenesis ... -
Biomechanical forces promote blood development through prostaglandin E2 and the cAMP–PKA signaling axis
(The Rockefeller University Press, 2015)Blood flow promotes emergence of definitive hematopoietic stem cells (HSCs) in the developing embryo, yet the signals generated by hemodynamic forces that influence hematopoietic potential remain poorly defined. Here we ... -
Biomedical Applications of Tetrazine Cycloadditions
(American Chemical Society, 2011)Disease mechanisms are increasingly being resolved at the molecular level. Biomedical success at this scale creates synthetic opportunities for combining specifically designed orthogonal reactions In applications such as ... -
Biomedical Markers and Psychiatric Morbidity of Neurasthenia Spectrum Disorders in Four Outpatient Clinics in India
(Medknow Publications, 2008)Context:Disorders of unexplained fatigue are researched globally and debated prominently concerning their biomedical and psychiatric comorbidity. Such studies are needed in India. Aims: To identify biomedical markers ... -
BioNumbers—The Database of Key Numbers in Molecular and Cell Biology
(Oxford University Press, 2009)BioNumbers (http://www.bionumbers.hms.harvard.edu) is a database of key numbers in molecular and cell biology—the quantitative properties of biological systems of interest to computational, systems and molecular cell ... -
Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection
(Nature Research, 2010)Nanoparticles have emerged as key materials for biomedical applications because of their unique and tunable physical properties, multivalent targeting capability, and high cargo capacity(1,2). Motivated by these properties ...