Browsing HMS Scholarly Articles by Title
Now showing items 1725-1744 of 17921
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Biomarkers: A Challenging Conundrum in Cardiovascular Disease
(Ovid Technologies (Wolters Kluwer Health), 2015)The use of biomarkers has proven utility in cardiovascular medicine and holds great promise for future advances, but their application requires considerable rigor in thinking and methodology. Numerous confounding factors ... -
Biomarkers: the next therapeutic hurdle in metastatic renal cell carcinoma
(Nature Publishing Group, 2012)Despite recent advances, metastatic renal cell carcinoma remains largely an incurable disease. Vascular endothelial growth factor and mammalian target of rapamycin inhibitors have provided improvements in clinical outcomes. ... -
Biomaterials and emerging anticancer therapeutics: engineering the microenvironment
(Nature Publishing Group, 2015)The microenvironment is increasingly recognized to have key roles in cancer, and biomaterials provide a means to engineer microenvironments both in vitro and in vivo to study and manipulate cancer. In vitro cancer models ... -
Biomechanical Considerations in the Pathogenesis of Osteoarthritis of the Knee
(Springer-Verlag, 2011)Osteoarthritis is the most common joint disease and a major cause of disability. The knee is the large joint most affected. While chronological age is the single most important risk factor of osteoarthritis, the pathogenesis ... -
Biomechanical forces promote blood development through prostaglandin E2 and the cAMP–PKA signaling axis
(The Rockefeller University Press, 2015)Blood flow promotes emergence of definitive hematopoietic stem cells (HSCs) in the developing embryo, yet the signals generated by hemodynamic forces that influence hematopoietic potential remain poorly defined. Here we ... -
Biomedical Applications of Tetrazine Cycloadditions
(American Chemical Society, 2011)Disease mechanisms are increasingly being resolved at the molecular level. Biomedical success at this scale creates synthetic opportunities for combining specifically designed orthogonal reactions In applications such as ... -
Biomedical Markers and Psychiatric Morbidity of Neurasthenia Spectrum Disorders in Four Outpatient Clinics in India
(Medknow Publications, 2008)Context:Disorders of unexplained fatigue are researched globally and debated prominently concerning their biomedical and psychiatric comorbidity. Such studies are needed in India. Aims: To identify biomedical markers ... -
BioNumbers—The Database of Key Numbers in Molecular and Cell Biology
(Oxford University Press, 2009)BioNumbers (http://www.bionumbers.hms.harvard.edu) is a database of key numbers in molecular and cell biology—the quantitative properties of biological systems of interest to computational, systems and molecular cell ... -
Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection
(Nature Research, 2010)Nanoparticles have emerged as key materials for biomedical applications because of their unique and tunable physical properties, multivalent targeting capability, and high cargo capacity(1,2). Motivated by these properties ... -
Bioorthogonal Click Chemistry-Based Synthetic Cell Glue
(Wiley, 2015)Artificial methods of cell adhesion can be effective in building functional cell complexes in vitro, but methods for in vivo use are currently lacking. Here, a chemical cell glue based on bioorthogonal click chemistry with ... -
Bioorthogonal Fluorophore Linked DFO–Technology Enabling Facile Chelator Quantification and Multimodal Imaging of Antibodies
(American Chemical Society, 2016)Herein we describe the development and application of a bioorthogonal fluorogenic chelate linker that can be used for facile creation of labeled imaging agents. The chelate linker is based on the trans-cyclooctene(TCO)-t ... -
Bioorthogonal Imaging of Aurora Kinase a in Live Cells
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Bioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of MET
(Public Library of Science, 2013)The hepatocyte growth factor receptor (MET) is a receptor tyrosine kinase (RTK) that has emerged as an important cancer target. Consequently, a number of different inhibitors varying in specificity are currently in clinical ... -
Biophysical and Functional Characterization of Rhesus Macaque IgG Subclasses
(Frontiers Media S.A., 2016)Antibodies raised in Indian rhesus macaques [Macaca mulatta (MM)] in many preclinical vaccine studies are often evaluated in vitro for titer, antigen-recognition breadth, neutralization potency, and/or effector function, ... -
Biophysical Prediction of Protein-Peptide Interactions and Signaling Networks Using Machine Learning
(Springer Science and Business Media LLC, 2020-01-06)In mammalian cells, much of signal transduction is mediated by weak protein-protein interactions between globular peptide-binding domains (PBDs) and unstructured peptidic motifs in partner proteins. The number and diversity ... -
Biophysical properties of presynaptic short-term plasticity in hippocampal neurons: insights from electrophysiology, imaging and mechanistic models
(Frontiers Media S.A., 2014)Hippocampal neurons show different types of short-term plasticity (STP). Some exhibit facilitation of their synaptic responses and others depression. In this review we discuss presynaptic biophysical properties behind ... -
Biopsy interpretation of colonic biopsies when inflammatory bowel disease is excluded
(Springer Nature, 2012)The interpretation of colonic biopsies related to inflammatory conditions can be challenging because the colorectal mucosa has a limited repertoire of morphologic responses to various injurious agents. Only few processes ...