Browsing HMS Scholarly Articles by Title

Now showing items 1749-1768 of 17922

    • Bipolar disorder in the digital age: new tools for the same illness 

      Torous, John; Summergrad, Paul; Nassir Ghaemi, S. (Springer Berlin Heidelberg, 2016)
      “Nothing is more difficult than to ascertain the length of time that a maniacal patient can exist without sleep.”—Dr. Sutherland (Br J Psychiatry 7(37):1–19, 1861). Dr. Sutherland’s patient was suffering from an acute manic ...

    • Birdshot chorioretinopathy in a male patient with facioscapulohumeral muscular dystrophy 

      Papavasileiou, Evangelia; Lobo, Ann-Marie (Springer Berlin Heidelberg, 2015)
      Background: We report a case of birdshot chorioretinopathy (BSCR) in a patient with facioscapulohumeral muscular dystrophy (FSHD). A 40-year-old male with history of facioscapulohumeral muscular dystrophy with significant ...

    • Birth Outcomes in a Prospective Pregnancy-Birth Cohort Study of Environmental Risk Factors in Kuwait: The TRACER Study 

      Alseaidan, Mohammad M.S.; Al Wotayan, Rihab; Christophi, Costas A.; Al-Makhseed, Massouma; Abu Awad, Yara; Nassan, Feiby; Ahmed, Ayah; Abraham, Smitha; Boley, Robert Bruce; James-Todd, Tamarra; Wright, Rosalind; Dockery, Douglas William; Behbehani, Kazem (Wiley-Blackwell, 2016)
      Background—Rapid development and westernisation in Kuwait and other Gulf states have been accompanied by rising rates of obesity, diabetes, asthma, and other chronic conditions. Prenatal experiences and exposures may be ...

    • Birth weight and later life adherence to unhealthy lifestyles in predicting type 2 diabetes: prospective cohort study 

      Li, Yanping; Ley, Sylvia H; Tobias, Deirdre K; Chiuve, Stephanie E; VanderWeele, Tyler J; Rich-Edwards, Janet W; Curhan, Gary C; Willett, Walter C; Manson, JoAnn E; Hu, Frank B; Qi, Lu (BMJ Publishing Group Ltd., 2015)
      Objectives To prospectively assess the joint association of birth weight and established lifestyle risk factors in adulthood with incident type 2 diabetes and to quantitatively decompose the attributing effects to birth ...

    • Birth Weight for Gestational Age Norms for a Large Cohort of Infants Born to HIV-Negative Women in Botswana Compared with Norms for U.S.-Born Black Infants 

      Parekh, Natasha K; Binda, Kelebogile; Souda, Sajini; Essex, Max; Matthews, Lynn Turner; Ribaudo, Heather J.; Chen, Jennifer Yin-zu; Ogwu, Anthony; Makhema, Joseph Moeketsi; Lockman, Shahin; Shapiro, Roger L. (BioMed Central, 2011)
      Background: Standard values for birth weight by gestational age are not available for sub-Saharan Africa, but are needed to evaluate incidence and risk factors for intrauterine growth retardation in settings where HIV, ...

    • Birth Weight, Genetic Susceptibility, and Adulthood Risk of Type 2 Diabetes 

      Li, Yanping; Qi, Qibin; Workalemahu, Tsegaselassie; Hu, Frank B.; Qi, Lu (American Diabetes Association, 2012)
      OBJECTIVE Both stressful intrauterine milieus and genetic susceptibility have been linked to later-life diabetes risk. The current study aims to examine the interaction between low birth weight, a surrogate measure of ...

    • Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood 

      Agha, Golareh; Hajj, Hanine; Rifas-Shiman, Sheryl L.; Just, Allan C.; Hivert, Marie-France; Burris, Heather H.; Lin, Xihong; Litonjua, Augusto A.; Oken, Emily; DeMeo, Dawn L.; Gillman, Matthew W.; Baccarelli, Andrea A. (BioMed Central, 2016)
      Background: Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic ...

    • Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013 

      Peretz, Jackye; Vrooman, Lisa; Ricke, William A.; Hunt, Patricia A.; Ehrlich, Shelley; Hauser, Russ; Padmanabhan, Vasantha; Taylor, Hugh S.; Swan, Shanna H.; VandeVoort, Catherine A.; Flaws, Jodi A. (NLM-Export, 2014)
      Background: In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on reproduction. Objective: ...

    • Bisphosphonate Prescribing, Persistence and Cumulative Exposure in Ontario, Canada 

      Burden, A. M.; Paterson, J. M.; Solomon, Daniel Hal; Mamdani, M.; Juurlink, D. N.; Cadarette, S. M. (Springer-Verlag, 2012)
      Summary: We studied new users of oral bisphosphonates and found that less than half persisted with therapy for 2 years, and interruptions in use were common. During a median observation period of 4.7 years, 10% of patients ...

    • Bisphosphonates and Risk of Cardiovascular Events: A Meta-Analysis 

      Kim, Dae Hyun; Rogers, James R.; Fulchino, Lisa A.; Kim, Caroline A.; Solomon, Daniel H.; Kim, Seoyoung C. (Public Library of Science, 2015)
      Background and Objectives Some evidence suggests that bisphosphonates may reduce atherosclerosis, while concerns have been raised about atrial fibrillation. We conducted a meta-analysis to determine the effects of ...

    • Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation 

      Ligthart, Symen; Vaez, Ahmad; Hsu, Yi-Hsiang; Stolk, Ronald; Uitterlinden, André G.; Hofman, Albert; Alizadeh, Behrooz Z.; Franco, Oscar H.; Dehghan, Abbas (BioMed Central, 2016)
      Background: Genome-wide association studies (GWAS) have identified multiple genetic loci for C-reactive protein (CRP) and lipids, of which some overlap. We aimed to identify genetic pleiotropy among CRP and lipids in order ...

    • BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma 

      Speranza, Maria-Carmela; Nowicki, Michal O.; Behera, Prajna; Cho, Choi-Fong; Chiocca, E. Antonio; Lawler, Sean E. (Nature Publishing Group, 2016)
      Glioblastoma is an aggressive, invasive tumor of the central nervous system (CNS). There is a widely acknowledged need for anti-invasive therapeutics to limit glioblastoma invasion. BKM-120 is a CNS-penetrant pan-class I ...

    • BL-8040, a CXCR4 Antagonist, in Combination with Pembrolizumab and Chemotherapy for Pancreatic Cancer: the COMBAT trial 

      Bockorny, Bruno; Wolpin, Brian
      Single agent immunotherapy has limited effect in pancreatic ductal adenocarcinoma (PDAC), underscoring the need to co-target alternative pathways. CXCR4 blockade promotes T-cell tumor infiltration and is synergistic with ...

    • Black Carbon Exposure, Oxidative Stress Genes, and Blood Pressure in a Repeated-measures Study 

      Mordukhovich, Irina; Wilker, Elissa Hope; Suh MacIntosh, Helen H.; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)
      Background: Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies ...

    • Black Carbon Exposures, Blood Pressure, and Interactions with Single Nucleotide Polymorphisms in MicroRNA Processing Genes 

      Wilker, Elissa Hope; Baccarelli, Andrea; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Wright, Robert O.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)
      Background: Black carbon (BC) is a marker of traffic pollution that has been associated with blood pressure (BP), but findings have been inconsistent. MicroRNAs (miRNAs) are emerging as key regulators of gene expression, ...

    • Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax 

      Montero, Joan; Stephansky, Jason; Cai, Tianyu; Griffin, Gabriel Kenneth; Cabal-Hierro, Lucia; Togami, Katsuhiro; Hogdal, Leah J.; Galinsky, Ilene; Morgan, Elizabeth Amy; Aster, Jon Christopher; Davids, Matthew Steven; Leboeuf, Nicole Renee; Stone, Richard Maury; Konopleva, Marina; Pemmaraju, Naveen; Letai, Anthony George; Lane, Andrew Alan (American Association for Cancer Research (AACR), 2016)
      Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy with dismal outcomes for which no standard therapy exists. We found that primary BPDCN cells were dependent on the anti-apoptotic ...

    • Blending Aboriginal and Western healing methods to treat intergenerational trauma with substance use disorder in Aboriginal peoples who live in Northeastern Ontario, Canada 

      Marsh, Teresa Naseba; Coholic, Diana; Cote-Meek, Sheila; Najavits, Lisa M (BioMed Central, 2015)
      As with many Indigenous groups around the world, Aboriginal communities in Canada face significant challenges with trauma and substance use. The complexity of symptoms that accompany intergenerational trauma and substance ...

    • Bleomycin and IL-1β–mediated Pulmonary Fibrosis is IL-17A Dependent 

      Wilson, Mark S.; Madala, Satish K.; Ramalingam, Thirumalai R.; Gochuico, Bernadette R.; Rosas, Ivan O.; Cheever, Allen W.; Wynn, Thomas A. (The Rockefeller University Press, 2010)
      Idiopathic pulmonary fibrosis (IPF) is a destructive inflammatory disease with limited therapeutic options. To better understand the inflammatory responses that precede and concur with collagen deposition, we used three ...

    • Blink patterns and lid-contact times in dry-eye and normal subjects 

      Ousler, George W; Abelson, Mark B; Johnston, Patrick R; Rodriguez, John; Lane, Keith; Smith, Lisa M (Dove Medical Press, 2014)
      Purpose To classify blinks in dry eye and normal subjects into six subtypes, and to define the blink rate and duration within each type of blink, as well as the total lid-contact time/minute. Materials and methods This was ...

    • The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells 

      Zhang, Haojian; Peng, Cong; Hu, Yiguo; Li, Huawei; Sheng, Zhi; Chen, Yaoyu; Sullivan, Con; Cerny, Jan; Hutchinson, Lloyd; Higgins, Anne; Miron, Patricia; Zhang, Xueqing; Brehm, Michael; Li, Dongguang; Green, Michael R.; Li, Shaoguang (2012)
      A therapeutic strategy for treating cancer is to target and eradicate cancer stem cells (CSCs) without harming their normal stem cell counterparts. The success of this approach relies on identification of molecular pathways ...