Browsing HMS Scholarly Articles by Title

Now showing items 1769-1788 of 17922

    • Blm10 Protein Promotes Proteasomal Substrate Turnover by an Active Gating Mechanism 

      Dange, Thomas; Smith, David; Noy, Tahel; Rommel, Philipp C.; Jurzitza, Lukas; Cordero, Radames B.; Legendre, Anne; Finley, Daniel; Goldberg, Alfred L.; Schmidt, Marion (American Society for Biochemistry and Molecular Biology, 2011)
      Background: Association of the proteasome core with activators regulates proteasome activity. Results: Blm10 association increases proteasome activity toward peptides and the unstructured proteasome substrate tau-441. This ...

    • Block matching 3D random noise filtering for absorption optical projection tomography 

      Feruglio, P. Fumene; Vinegoni, C.; Gros, J.; Sbarbati, A.; Weissleder, R. (IOP Publishing, 2010)
      Absorption and emission optical projection tomography (OPT), alternatively referred to as optical computed tomography (optical-CT) and optical-emission computed tomography (optical-ECT), are recently developed three-dimensional ...

    • Blockade of CD40-CD154 Costimulatory Pathway Promotes Survival of Allogeneic Corneal Transplants 

      Qian, Ying; Boisgerault, Florence; Benichou, Gilles A.; Dana, Reza (Association for Research in Vision and Ophthalmology, 2001)
      purpose. To determine the effect of systemic anti-CD154 monoclonal antibody on the survival of orthotopic murine corneal transplants. methods. BALB/c mice were used as recipients of syngeneic, multiple minor histocompatability ...

    • Blockade of Glioma Proliferation through Allosteric Inhibition of JAK2 

      He, Kunyan; Qi, Qi; Chan, Chi-Bun; Xiao, Ge; Liu, Xia; Tucker-Burden, Carol; Wang, Liya; Mao, Hui; Lu, Xiang; McDonald, Frank E.; Luo, Hongbo; Fan, Qi-Wen; Weiss, William A.; Sun, Shi-Yong; Brat, Daniel J.; Ye, Keqiang (American Association for the Advancement of Science (AAAS), 2013)
      The gene that encodes the epidermal growth factor receptor (EGFR) is frequently overexpressed or mutated in human cancers, including glioblastoma. However, the efficacy of EGFR-targeted small-molecule inhibitors or monoclonal ...

    • Blockade of Prolymphangiogenic Vascular Endothelial Growth Factor C in Dry Eye Disease 

      Goyal, Sunali; Chauhan, Sunil Kumar; Dana, Reza (American Medical Association (AMA), 2012)
      Objective To determine if blocking prolymphangiogenic factors like VEGF-C would suppress alloimmunity in dry eye disease (DED) using a murine model. Methods The effects of intraperitoneal injections of 400 μg of ...

    • Blockade of the Programmed Death-1 (PD1) Pathway Undermines Potent Genetic Protection from Type 1 Diabetes 

      Kochupurakkal, Nora M.; Kruger, Annie J.; Tripathi, Sudipta; Zhu, Bing; Adams, La Tonya; Rainbow, Daniel B.; Rossini, Aldo; Greiner, Dale L.; Sayegh, Mohamed H.; Wicker, Linda S.; Guleria, Indira (Public Library of Science, 2014)
      Aims/Hypothesis Inhibition of PD1-PDL1 signaling in NOD mice accelerates onset of type 1 diabetes implicating this pathway in suppressing the emergence of pancreatic beta cell reactive T-cells. However, the molecular ...

    • Blockade of VEGFR2 and Not VEGFR1 Can Limit Diet-Induced Fat Tissue Expansion: Role of Local versus Bone Marrow-Derived Endothelial Cells 

      Tam, Joshua; Duda, Dan Gabriel; Perentes, Jean Y.; Quadri, Rehan S.; Fukumura, Dai; Jain, Rakesh K. (Public Library of Science, 2009)
      Background: We investigated if new vessel formation in fat involves the contribution of local tissue-derived endothelial cells (i.e., angiogenesis) or bone marrow-derived cells (BMDCs, i.e. vasculogenesis) and if antiangiogenic ...

    • Blocker State Dependence and Trapping in Hyperpolarization-Activated Cation Channels Evidence for an Intracellular Activation Gate 

      Shin, Ki Soon; Rothberg, Brad S.; Yellen, Gary; Shin, K. S.; Rothberg, B. S.; Yellen, G. (Rockefeller University Press, 2001)

    • Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes 

      Rodriguez-Muela, Natalia; Parkhitko, Andrey; Grass, Tobias; Gibbs, Rebecca; Norabuena, Erika M.; Perrimon, Norbert; Singh, Rajat; Rubin, Lee (American Society for Clinical Investigation, 2018-06-11)
      Spinal muscular atrophy (SMA), a degenerative motor neuron (MN) disease, caused by loss of functional survival of motor neuron (SMN) protein due to SMN1 gene mutations, is a leading cause of infant mortality. Increasing ...

    • Blocking the formation of radiation–induced breast cancer stem cells 

      Wang, Yangyang; Li, Wende; Patel, Shalin S.; Cong, Juan; Zhang, Nan; Sabbatino, Francesco; Liu, Xiaoyan; Qi, Yuan; Huang, Peigen; Lee, Hang; Taghian, Alphonse; Li, Jian-Jian; DeLeo, Albert B.; Ferrone, Soldano; Epperly, Michael W.; Ferrone, Cristina R.; Ly, Amy; Brachtel, Elena F.; Wang, Xinhui (Impact Journals LLC, 2014)
      The goal of adjuvant (post-surgery) radiation therapy (RT) for breast cancer (BC) is to eliminate residual cancer cells, leading to better local tumor control and thus improving patient survival. However, radioresistance ...

    • Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging Study 

      Stein-Merlob, Ashley F.; Kessinger, Chase W.; Erdem, S. Sibel; Zelada, Henry; Hilderbrand, Scott A.; Lin, Charles P.; Tearney, Guillermo J.; Jaff, Michael R.; Reed, Guy L.; Henke, Peter K.; McCarthy, Jason R.; Jaffer, Farouc A. (Ivyspring International Publisher, 2015)
      Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. In particular, it is unknown how age-dependent ...

    • Blood and War 

      Hedley-Whyte, John; Milamed, Debra (The Ulster Medical Society, 2010)
      In 1894 Ulsterman and pathologist Almroth Wright described the citation of blood. Twenty-one years later it was introduced into wartime and clinical practice. Harvard Medical School had a large part in providing Colonel ...

    • Blood Banking in Living Droplets 

      Samot, Josh; Moon, Sangjun; Shao, Lei; Zhang, Xiaohui; Xu, Feng; Song, YoungSeok; Keles, Hasan Onur; Matloff, Laura; Markel, Jordan; Demirci, Utkan (Public Library of Science, 2011)
      Blood banking has a broad public health impact influencing millions of lives daily. It could potentially benefit from emerging biopreservation technologies. However, although vitrification has shown advantages over traditional ...

    • Blood Donation and Colorectal Cancer Incidence and Mortality in Men 

      Zhang, Xuehong; Ma, Jing; Wu, Kana; Chan, Andrew Tan; Fuchs, Charles Stewart; Giovannucci, Edward L. (Public Library of Science, 2012)
      Background: Although blood donations may reduce body iron stores, to date, prospective data on frequent blood donation and colorectal cancer risk are limited. Methodology/Principal Findings: We tested whether frequent ...

    • Blood Epigenetic Age may Predict Cancer Incidence and Mortality 

      Zheng, Yinan; Joyce, Brian T.; Colicino, Elena; Liu, Lei; Zhang, Wei; Dai, Qi; Shrubsole, Martha J.; Kibbe, Warren A.; Gao, Tao; Zhang, Zhou; Jafari, Nadereh; Vokonas, Pantel; Schwartz, Joel; Baccarelli, Andrea A.; Hou, Lifang (Elsevier, 2016)
      Biological measures of aging are important for understanding the health of an aging population, with epigenetics particularly promising. Previous studies found that tumor tissue is epigenetically older than its donors are ...

    • Blood Group, Immunity, and Risk of Infection with Vibrio cholerae in an Area of Endemicity 

      Harris, Jason B.; Khan, Ashraful I.; LaRocque, Regina C.; Dorer, David J.; Chowdhury, Fahima; Faruque, Abu G.; Sack, David A.; Ryan, Edward T.; Qadri, Firdausi; Calderwood, Stephen B. (American Society for Microbiology, 2005)
      Individuals with blood group O are more susceptible than other individuals to severe cholera, although the mechanism underlying this association is unknown. To assess the respective roles of both intrinsic host factors and ...

    • Blood Lead Levels and Serum Insulin-Like Growth Factor 1 Concentrations in Peripubertal Boys 

      Fleisch, Abby F.; Burns, Jane S.; Williams, Paige L.; Lee, Mary M.; Sergeyev, Oleg; Korrick, Susan A.; Hauser, Russ (National Institute of Environmental Health Sciences, 2013)
      Background: Childhood lead exposure has been associated with growth delay. However, the association between blood lead levels (BLLs) and insulin-like growth factor 1 (IGF-1) has not been characterized in a large cohort ...

    • Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice 

      Schoretsanitis, Georgios; Kane, John M.; Correll, Christoph U.; Marder, Stephen R.; Citrome, Leslie; Newcomer, John W.; Robinson, Delbert G.; Goff, Donald C.; Kelly, Deanna L.; Freudenreich, Oliver; Piacentino, Daria; Paulzen, Michael; Conca, Andreas; Zernig, Gerald; Haen, Ekkehard; Baumann, Pierre; Hiemke, Christoph; Gründer, Gerhard (Physicians Postgraduate Press, Inc, 2020-05-19)

    • Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice; a Joint Consensus Statement of the American Society of Clinical Psychopharmacology (ASCP) and the Therapeutic Drug Monitoring (TDM) Task Force of the Arbeitsgemeinschaft Für Neuropsychopharmakologie Und Pharmakopsychiatrie (AGNP) 

      Schoretsanitis, Georgios; Kane, John; Correll, Christoph U.; Marder, Stephen R.; Citrome, Leslie; Newcomer, John W.; Robinson, Delbert G.; Goff, Donald; Kelly, Deanna L.; Freudenreich, Oliver; Piacentino, Daria; Paulzen, Michael; Conca, Andreas; Zernig, Gerald; Haen, Ekkehard; Baumann, Pierre; Hiemke, Christoph; Gründer, Gerhard (Physicians Postgraduate Press, Inc, 2020-05-19)
      Objective The quantification of antipsychotic levels in blood, also known as therapeutic drug monitoring (TDM), is a potentially useful tool of modern personalized therapy that can be applied to augment antipsychotic use ...

    • Blood Oxygen Depletion Is Independent of Dive Function in a Deep Diving Vertebrate, the Northern Elephant Seal 

      Meir, Jessica U.; Robinson, Patrick W.; Vilchis, L. Ignacio; Kooyman, Gerald L.; Costa, Daniel P.; Ponganis, Paul J. (Public Library of Science, 2013)
      Although energetics is fundamental to animal ecology, traditional methods of determining metabolic rate are neither direct nor instantaneous. Recently, continuous blood oxygen (O2) measurements were used to assess energy ...