Browsing HMS Scholarly Articles by Title

Now showing items 17830-17849 of 17921

    • Work Stress as a Risk Factor for Cardiovascular Disease 

      Kivimäki, Mika; Kawachi, Ichiro (Springer US, 2015)
      The role of psychosocial work stress as a risk factor for chronic disease has been the subject of considerable debate. Many researchers argue in support of a causal connection while others remain skeptical and have argued ...

    • Workgroup Report: Workshop on Source Apportionment of Particulate Matter Health Effects—Intercomparison of Results and Implications 

      Thurston, George D.; Ito, Kazuhiko; Mar, Therese; Christensen, William F.; Eatough, Delbert J.; Henry, Ronald C.; Lall, Ramona; Larson, Timothy V.; Neas, Lucas; Pinto, Joseph; Stölzel, Matthias; Hopke, Philip K.; Kim, Eugene; Laden, Francine; Liu, Hao; Suh MacIntosh, Helen H. (National Institute of Environmental Health Sciences, 2005)
      Although the association between exposure to ambient fine particulate matter with aerodynamic diameter < 2.5 μm (PM\(_{2.5}\)) and human mortality is well established, the most responsible particle types/sources are not ...

    • Workplace Determinants of Social Capital: Cross-Sectional and Longitudinal Evidence from a Finnish Cohort Study 

      Oksanen, Tuula; Kawachi, Ichiro; Kouvonen, Anne; Takao, Soshi; Suzuki, Etsuji; Virtanen, Marianna; Pentti, Jaana; Kivimäki, Mika; Vahtera, Jussi (Public Library of Science, 2013)
      Objective: To examine which contextual features of the workplace are associated with social capital. Methods: This is a cohort study of 43,167 employees in 3090 Finnish public sector workplaces who responded to a survey ...

    • Workplace exposure to passive smoking and risk of cardiovascular disease: summary of epidemiologic studies 

      Kawachi, Ichiro; Colditz, Graham A. (National Institute of Environmental Health Sciences, 1999)
      We reviewed the published epidemiologic studies addressing the relationship between workplace exposure to environmental tobacco smoke (ETS) and cardiovascular disease risk in three case-control studies and three cohort ...

    • World Endometriosis Research Foundation Endometriosis Phenome and biobanking harmonization project: II. Clinical and covariate phenotype data collection in endometriosis research 

      Vitonis, Allison F.; Vincent, Katy; Rahmioglu, Nilufer; Fassbender, Amelie; Buck Louis, Germaine M.; Hummelshoj, Lone; Giudice, Linda C.; Stratton, Pamela; Adamson, G. David; Becker, Christian M.; Zondervan, Krina T.; Missmer, Stacey A. (2014)
      Objective: To harmonize the collection of nonsurgical clinical and epidemiologic data relevant to endometriosis research, allowing large-scale collaboration. Design: An international collaboration involving 34 clinical/academic ...

    • World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis 

      Gibb, Herman; Devleesschauwer, Brecht; Bolger, P. Michael; Wu, Felicia; Ezendam, Janine; Cliff, Julie; Zeilmaker, Marco; Verger, Philippe; Pitt, John; Baines, Janis; Adegoke, Gabriel; Afshari, Reza; Liu, Yan; Bokkers, Bas; van Loveren, Henk; Mengelers, Marcel; Brandon, Esther; Havelaar, Arie H.; Bellinger, David (F1000Research, 2015)
      Background: Chemical exposures have been associated with a variety of health effects; however, little is known about the global disease burden from foodborne chemicals. Food can be a major pathway for the general population’s ...

    • A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells 

      Skoge, Monica; Wong, Elisabeth; Hamza, Bashar; Bae, Albert; Martel, Joseph; Kataria, Rama; Keizer-Gunnink, Ineke; Kortholt, Arjan; Van Haastert, Peter J. M.; Charras, Guillaume; Janetopoulos, Christopher; Irimia, Daniel (Public Library of Science, 2016)
      Chemotaxis is the ability to migrate towards the source of chemical gradients. It underlies the ability of neutrophils and other immune cells to hone in on their targets and defend against invading pathogens. Given the ...

    • Worse health-related quality of life and hip function in female patients with elevated chromium levels: A prospective study of 659 patients with a recalled THR metal-on-metal implant 

      Hussey, Daniel K; Madanat, Rami; Donahue, Gabrielle S; Rolfson, Ola; Muratoglu, Orhun K; Malchau, Henrik (Taylor & Francis, 2016)
      Background and purpose Blood metal ion levels can be an indicator for detecting implant failure in metal-on-metal (MoM) hip arthroplasties. Little is known about the effect of bilateral MoM implants on metal ion levels and ...

    • Worse Prognosis in Papillary, Compared to Tubular, Early Gastric Carcinoma 

      Yu, Huiping; Fang, Cheng; Chen, Lin; Shi, Jiong; Fan, Xianshan; Zou, Xiaoping; Huang, Qin (Ivyspring International Publisher, 2017)
      Purpose: Papillary early gastric carcinoma (EGC) is uncommon but shows worse prognosis in our most recent study in a Chinese population with unknown reasons. The aim of the present study was to further investigate risk ...

    • Worth the wait: effects of age of onset of marijuana use on white matter and impulsivity 

      Gruber, Staci A.; Dahlgren, Mary Kathryn; Sagar, Kelly A.; Gönenç, Atilla; Lukas, Scott E. (Springer Berlin Heidelberg, 2013)
      Rationale: Marijuana (MJ) use continues to rise, and as the perceived risk of using MJ approaches an all-time historic low, initiation of MJ use is occurring at even younger ages. As adolescence is a critical period of ...

    • WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers 

      Bass, Adam; Chan, Edmond; Shibue, Tsukasa; McFarland, James; Gaeta, Benjamin; Ghandi, Mahmoud; Dumont, Nancy; Gonzalez, Alfredo; McPartlan, Justine; Li, Tianxia; Zhang, Yanxi; Liu, Jie Bin; Lazaro, Jean-Bernard; Gu, Peili; Piett, Cortt; Apffel, Annie; Ali, Syed Omar; Deasy, Rebecca; Keskula, Paula; Ng, Raymond; Roberts, Emma; Reznichenko, Elizaveta; Leung, Lisa; Alimova, Maria; Schenone, Monica; Islam, Manirul; Maruvka, Yosef; Liu, Yang; Roper, Jatin; Raghavan, Srivatsan; Giannakis, Marios; Tseng, Yuen-Yi; Nagel, Zachary; D’Andrea, Alan; Root, David; Boehm, Jesse; Getz, Gad; Chang, Sandy; Golub, Todd; Tsherniak, Aviad; Vazquez, Francisca (Cold Spring Harbor Laboratory, 2018-12-21)
      Synthetic lethality, an interaction whereby the co-occurrence of two genetic events leads to cell death but one event alone does not, can be exploited for cancer therapeutics1. DNA repair processes represent attractive ...

    • WSES guidelines for emergency repair of complicated abdominal wall hernias 

      Sartelli, Massimo; Coccolini, Federico; van Ramshorst, Gabrielle H; Campanelli, Giampiero; Mandalà, Vincenzo; Ansaloni, Luca; Moore, Ernest E; Peitzman, Andrew; Velmahos, George; Moore, Fredrick Alan; Leppaniemi, Ari; Burlew, Clay Cothren; Biffl, Walter; Koike, Kaoru; Kluger, Yoram; Fraga, Gustavo P; Ordonez, Carlos A; Di Saverio, Salomone; Agresta, Ferdinando; Sakakushev, Boris; Gerych, Igor; Wani, Imtiaz; Kelly, Michael D; Gomes, Carlos Augusto; Faro, Mario Paulo; Taviloglu, Korhan; Demetrashvili, Zaza; Lee, Jae Gil; Vettoretto, Nereo; Guercioni, Gianluca; Tranà, Cristian; Cui, Yunfeng; Kok, Kenneth YY; Ghnnam, Wagih M; Abbas, Ashraf El-Sayed; Sato, Norio; Marwah, Sanjay; Rangarajan, Muthukumaran; Ben-Ishay, Offir; Adesunkanmi, Abdul Rashid K; Segovia Lohse, Helmut Alfredo; Kenig, Jakub; Mandalà, Stefano; Patrizi, Andrea; Scibé, Rodolfo; Catena, Fausto (BioMed Central, 2013)
      Emergency repair of complicated abdominal hernias is associated with poor prognosis and a high rate of post-operative complications. A World Society of Emergency Surgery (WSES) Consensus Conference was held in Bergamo in ...

    • WSES guidelines for management of Clostridium difficile infection in surgical patients 

      Sartelli, Massimo; Malangoni, Mark A.; Abu-Zidan, Fikri M.; Griffiths, Ewen A.; Di Bella, Stefano; McFarland, Lynne V.; Eltringham, Ian; Shelat, Vishal G.; Velmahos, George C.; Kelly, Ciarán P.; Khanna, Sahil; Abdelsattar, Zaid M.; Alrahmani, Layan; Ansaloni, Luca; Augustin, Goran; Bala, Miklosh; Barbut, Frédéric; Ben-Ishay, Offir; Bhangu, Aneel; Biffl, Walter L.; Brecher, Stephen M.; Camacho-Ortiz, Adrián; Caínzos, Miguel A.; Canterbury, Laura A.; Catena, Fausto; Chan, Shirley; Cherry-Bukowiec, Jill R.; Clanton, Jesse; Coccolini, Federico; Cocuz, Maria Elena; Coimbra, Raul; Cook, Charles H.; Cui, Yunfeng; Czepiel, Jacek; Das, Koray; Demetrashvili, Zaza; Di Carlo, Isidoro; Di Saverio, Salomone; Dumitru, Irina Magdalena; Eckert, Catherine; Eckmann, Christian; Eiland, Edward H.; Enani, Mushira Abdulaziz; Faro, Mario; Ferrada, Paula; Forrester, Joseph Derek; Fraga, Gustavo P.; Frossard, Jean Louis; Galeiras, Rita; Ghnnam, Wagih; Gomes, Carlos Augusto; Gorrepati, Venkata; Ahmed, Mohamed Hassan; Herzog, Torsten; Humphrey, Felicia; Kim, Jae Il; Isik, Arda; Ivatury, Rao; Lee, Yeong Yeh; Juang, Paul; Furuya-Kanamori, Luis; Karamarkovic, Aleksandar; Kim, Peter K; Kluger, Yoram; Ko, Wen Chien; LaBarbera, Francis D.; Lee, Jae Gil; Leppaniemi, Ari; Lohsiriwat, Varut; Marwah, Sanjay; Mazuski, John E.; Metan, Gokhan; Moore, Ernest E.; Moore, Frederick Alan; Nord, Carl Erik; Ordoñez, Carlos A.; Júnior, Gerson Alves Pereira; Petrosillo, Nicola; Portela, Francisco; Puri, Basant K.; Ray, Arnab; Raza, Mansoor; Rems, Miran; Sakakushev, Boris E.; Sganga, Gabriele; Spigaglia, Patrizia; Stewart, David B.; Tattevin, Pierre; Timsit, Jean Francois; To, Kathleen B.; Tranà, Cristian; Uhl, Waldemar; Urbánek, Libor; van Goor, Harry; Vassallo, Angela; Zahar, Jean Ralph; Caproli, Emanuele; Viale, Pierluigi (BioMed Central, 2015)
      In the last two decades there have been dramatic changes in the epidemiology of Clostridium difficile infection (CDI), with increases in incidence and severity of disease in many countries worldwide. The incidence of CDI ...

    • WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis 

      Di Saverio, Salomone; Birindelli, Arianna; Kelly, Micheal D.; Catena, Fausto; Weber, Dieter G.; Sartelli, Massimo; Sugrue, Michael; De Moya, Mark; Gomes, Carlos Augusto; Bhangu, Aneel; Agresta, Ferdinando; Moore, Ernest E.; Soreide, Kjetil; Griffiths, Ewen; De Castro, Steve; Kashuk, Jeffry; Kluger, Yoram; Leppaniemi, Ari; Ansaloni, Luca; Andersson, Manne; Coccolini, Federico; Coimbra, Raul; Gurusamy, Kurinchi S.; Campanile, Fabio Cesare; Biffl, Walter; Chiara, Osvaldo; Moore, Fred; Peitzman, Andrew B.; Fraga, Gustavo P.; Costa, David; Maier, Ronald V.; Rizoli, Sandro; Balogh, Zsolt J; Bendinelli, Cino; Cirocchi, Roberto; Tonini, Valeria; Piccinini, Alice; Tugnoli, Gregorio; Jovine, Elio; Persiani, Roberto; Biondi, Antonio; Scalea, Thomas; Stahel, Philip; Ivatury, Rao; Velmahos, George; Andersson, Roland (BioMed Central, 2016)
      Acute appendicitis (AA) is among the most common cause of acute abdominal pain. Diagnosis of AA is challenging; a variable combination of clinical signs and symptoms has been used together with laboratory findings in several ...

    • An X Chromosome Association Scan of the Norfolk Island Genetic Isolate Provides Evidence for a Novel Migraine Susceptibility Locus at Xq12 

      Maher, Bridget H.; Lea, Rod A.; Benton, Miles; Cox, Hannah C.; Bellis, Claire; Carless, Melanie; Dyer, Thomas D.; Curran, Joanne; Charlesworth, Jac C.; Schürks, Markus; Blangero, John; Griffiths, Lyn R.; Buring, Julie Elizabeth; Kurth, Tobias; Chasman, Daniel Ian; Ridker, Paul M. (Public Library of Science, 2012)
      Migraine is a common and debilitating neurovascular disorder with a complex envirogenomic aetiology. Numerous studies have demonstrated a preponderance of women affected with migraine and previous pedigree linkage studies ...

    • X-Box Binding Protein 1 Is Essential for Insulin Regulation of Pancreatic α-Cell Function 

      Akiyama, Masaru; Liew, Chong Wee; Lu, Shusheng; Hu, Jiang; Martinez, Rachael; Hambro, Ben; Kennedy, Robert T.; Kulkarni, Rohit N. (American Diabetes Association, 2013)
      Patients with type 2 diabetes (T2D) often exhibit hyperglucagonemia despite hyperglycemia, implicating defective α-cell function. Although endoplasmic reticulum (ER) stress has been suggested to underlie β-cell dysfunction ...

    • X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription 

      Yildirim, Eda; Sadreyev, Ruslan I.; Pinter, Stefan F.; Lee, Jeannie T. (2013)
      Dosage compensation in mammals occurs at two levels. In addition to balancing X-chromosome dosage between males and females via X-inactivation, mammals also balance dosage of Xs and autosomes. It has been proposed that ...

    • X-linked myotubular myopathy in Rottweiler dogs is caused by a missense mutation in Exon 11 of the MTM1 gene 

      Shelton, G Diane; Rider, Branden E; Child, Georgina; Tzannes, Sophia; Guo, Ling T; Moghadaszadeh, Behzad; Troiano, Emily C; Haase, Bianca; Wade, Claire M; Beggs, Alan H (BioMed Central, 2015)
      Background: Congenital and inherited myopathies in dogs are faithful models of human muscle diseases and are being recognized with increasing frequency. In fact, canine models of dystrophin deficient muscular dystrophy and ...

    • X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor 

      Elkins, Jonathan M.; Wang, Jing; Deng, Xianming; Pattison, Michael J.; Arthur, J. Simon C.; Erazo, Tatiana; Gomez, Nestor; Lizcano, Jose M.; Gray, Nathanael S.; Knapp, Stefan (American Chemical Society, 2013)
      The protein kinase ERK5 (MAPK7) is an emerging drug target for a variety of indications, in particular for cancer where it plays a key role mediating cell proliferation, survival, epithelial–mesenchymal transition, and ...

    • The X-Trials: Neural Correlates of an Inhibitory Control Task in Children and Adults 

      Davis, Elysia Poggi; Bruce, Jacqueline; Snyder, Kelly; Nelson, Charles A. (MIT Press - Journals, 2003)
      Event-related potentials (ERPs) were used to examine developmental differences between adults and 6-year-old children in the neural processes involved in an inhibitory control task. Twenty adults and 21 children completed ...