Browsing HMS Scholarly Articles by Title

Now showing items 1911-1930 of 17922

    • Brief inhalation of nitric oxide increases resuscitation success and improves 7-day-survival after cardiac arrest in rats: a randomized controlled animal study 

      Brücken, Anne; Derwall, Matthias; Bleilevens, Christian; Stoppe, Christian; Götzenich, Andreas; Gaisa, Nadine T.; Weis, Joachim; Nolte, Kay Wilhelm; Rossaint, Rolf; Ichinose, Fumito; Fries, Michael (BioMed Central, 2015)
      Introduction: Inhaled nitric oxide (iNO) improves outcomes when given post systemic ischemia/reperfusion injury. iNO given during cardiopulmonary resuscitation (CPR) may therefore improve return of spontaneous circulation ...

    • Brief Parenteral Nutrition Accelerates Weight Gain, Head Growth Even in Healthy VLBWs 

      Morisaki, Naho; Belfort, Mandy B.; McCormick, Marie C.; Mori, Rintaro; Noma, Hisashi; Kusuda, Satoshi; Fujimura, Masanori (Public Library of Science, 2014)
      Introduction: Whether parenteral nutrition benefits growth of very low birth weight (VLBW) preterm infants in the setting of rapid enteral feeding advancement is unclear. Our aim was to examine this issue using data from ...

    • A Brief Perspective on the Early History of American Infectious Disease Epidemiology 

      Kass, Edward Harold (Yale Journal of Biology and Medicine, 1987)
      The early history of epidemiology is closely linked to the history of infectious diseases and can be divided into three distinct periods. The earliest period, which can be traced to the writings of Hippocrates in the third ...

    • Brief Report: Identification of BACH2 and RAD51B as Rheumatoid Arthritis Susceptibility Loci in a Meta-Analysis of Genome-Wide Data 

      McAllister, Kate; Yarwood, Annie; Bowes, John; Orozco, Gisela; Viatte, Sebastian; Diogo, Dorothée; Hocking, Lynne J; Steer, Sophia; Wordsworth, Paul; Wilson, A G; Morgan, Ann W; Kremer, Joel M; Pappas, Dimitrios; Gregersen, Peter; Klareskog, Lars; Plenge, Robert; Barton, Anne; Greenberg, Jeffrey; Worthington, Jane; Eyre, Stephen (BlackWell Publishing Ltd, 2013)
      Objective: A recent high-density fine-mapping (ImmunoChip) study of genetic associations in rheumatoid arthritis (RA) identified 14 risk loci with validated genome-wide significance, as well as a number of loci showing ...

    • Brief Report: Question-Asking and Collateral Language Acquisition in Children with Autism 

      Koegel, Lynn Kern; Koegel, Robert L.; Barnes, Cynthia Carter; Green-Hopkins, Israel (Springer Verlag, 2010)
      The literature suggests children with autism use communication primarily for requests and protests, and almost never for information-seeking. This study investigated whether teaching “Where” questions using intrinsic ...

    • Brief Report: Relationship Among Viral Load Outcomes in HIV Treatment Interruption Trials 

      Treasure, Graham C.; Aga, Evgenia; Bosch, Ronald J.; Mellors, John W.; Kuritzkes, Daniel R.; Para, Michael; Gandhi, Rajesh T.; Li, Jonathan Z. (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2016)
      Abstract: Viral load (VL) rebound timing and set point were analyzed in 235 participants undergoing analytic treatment interruption (ATI) in 6 AIDS Clinical Trials Group studies. There was no significant association between ...

    • A brief review of exercise, bipolar disorder, and mechanistic pathways 

      Thomson, Daniel; Turner, Alyna; Lauder, Sue; Gigler, Margaret E.; Berk, Lesley; Singh, Ajeet B.; Pasco, Julie A.; Berk, Michael; Sylvia, Louisa (Frontiers Media S.A., 2015)
      Despite evidence that exercise has been found to be effective in the treatment of depression, it is unclear whether these data can be extrapolated to bipolar disorder. Available evidence for bipolar disorder is scant, with ...

    • Brief Review: Sleep Health and Safety for Transportation Workers 

      Quan, Stuart Fun; Barger, Laura (Arizona Thoracic Society, 2015)
      Accidents related to sleepiness related fatigue are an important concern in transportation related industries. This brief review outlines the public safety concerns with sleepiness related fatigue in the railroad, aviation ...

    • A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research 

      Yeatts, Karin; Sly, Peter; Martinez, Fernando; Geller, Andrew; Bromberg, Philip; Enright, Paul; Koren, Hillel; Weissman, David; Selgrade, MaryJane; Shore, Stephanie; Weiss, Scott Tillman (National Institute of Environmental Health Sciences, 2006)
      Relative to research on effects of environmental exposures on exacerbation of existing asthma, little research on incident asthma and environmental exposures has been conducted. However, this research is needed to better ...

    • Brief Trust/Mistrust in God Scale: psychometric properties of the Farsi version in Muslims 

      Hafizi, Sina; Rosmarin, David Hillel; G. Koenig, Harold (Informa UK Limited, 2013)
      In Iran, a Middle Eastern Islamic country, far too little attention has been paid to the validation and cultural adaptation of measures of religion/spirituality. This has limited the potential for research in this area. ...

    • The Bright Side and Dark Side of Workplace Social Capital: Opposing Effects of Gender on Overweight among Japanese Employees 

      Kobayashi, Tomoko; Suzuki, Etsuji; Oksanen, Tuula; Kawachi, Ichiro; Takao, Soshi (Public Library of Science, 2014)
      Background: A growing number of studies have sought to examine the health associations of workplace social capital; however, evidence of associations with overweight is sparse. We examined the association between individual ...

    • Bringing non-human primate research into the post-genomic era: how monkeys are teaching us about elite controllers of HIV/AIDS 

      Vallender, Eric J (BioMed Central, 2014)
      Whole-genome sequencing of Mauritian cynomolgus macaques reveals novel candidate loci for controlling simian immunodeficiency virus replication. See related Research, http://genomebiology.com/2014/15/11/478

    • BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1–Chk1 pathway, implicating checkpoint dysfunction in microcephaly 

      Lin, Shiaw-Yih; Rai, Rekha; Li, Kaiyi; Xu, Zhi-Xiang; Elledge, Stephen J. (National Academy of Sciences, 2005)
      BRIT1 [BRCT-repeat inhibitor of hTERT expression], a repressor of human telomerase function, is implicated in cellular immortalization. Here, we find that BRIT1 acts as a regulator of both the intra-S and G(2)/M checkpoints. ...

    • Broad activation of latent HIV-1 in vivo 

      Barton, Kirston; Hiener, Bonnie; Winckelmann, Anni; Rasmussen, Thomas Aagaard; Shao, Wei; Byth, Karen; Lanfear, Robert; Solomon, Ajantha; McMahon, James; Harrington, Sean; Buzon, Maria; Lichterfeld, Mathias; Denton, Paul W.; Olesen, Rikke; Østergaard, Lars; Tolstrup, Martin; Lewin, Sharon R.; Søgaard, Ole Schmeltz; Palmer, Sarah (Nature Publishing Group, 2016)
      The ‘shock and kill' approach to cure human immunodeficiency virus (HIV) includes transcriptional induction of latent HIV-1 proviruses using latency-reversing agents (LRAs) with targeted immunotherapy to purge infected ...

    • Broad and Gag-Biased HIV-1 Epitope Repertoires are Associated with Lower Viral Loads 

      Rolland, Morgane; Heckerman, David; Deng, Wenjie; Rousseau, Christine M.; Coovadia, Hoosen; Bishop, Karen; Goulder, Philip J.; Walker, Bruce David; Brander, Christian; Mullins, James I. (Public Library of Science, 2008)
      Background: HLA class-I alleles differ in their ability to control HIV replication through cell-mediated immune responses. No consistent associations have been found between the breadth of Cytotoxic T Lymphocytes (CTL) ...

    • Broad Neutralization by a Combination of Antibodies Recognizing the CD4 Binding Site and a New Conformational Epitope on the HIV-1 Envelope Protein 

      Klein, Florian; Gaebler, Christian; Mouquet, Hugo; Sather, D. Noah; Lehmann, Clara; Scheid, Johannes F.; Kraft, Zane; Liu, Yan; Pietzsch, John; Hurley, Arlene; Poignard, Pascal; Feizi, Ten; Morris, Lynn; Walker, Bruce David; Fätkenheuer, Gerd; Seaman, Michael S.; Stamatatos, Leonidas; Nussenzweig, Michel C. (The Rockefeller University Press, 2012)
      Two to three years after infection, a fraction of HIV-1–infected individuals develop serologic activity that neutralizes most viral isolates. Broadly neutralizing antibodies that recognize the HIV-1 envelope protein have ...

    • A Broad Phenotypic Screen Identifies Novel Phenotypes Driven by a Single Mutant Allele in Huntington’s Disease CAG Knock-In Mice 

      Hölter, Sabine M.; Stromberg, Mary; Kovalenko, Marina; Garrett, Lillian; Glasl, Lisa; Lopez, Edith; Guide, Jolene; Götz, Alexander; Hans, Wolfgang; Becker, Lore; Rathkolb, Birgit; Rozman, Jan; Schrewed, Anja; Klingenspor, Martin; Klopstock, Thomas; Schulz, Holger; Wolf, Eckhard; Wursta, Wolfgang; Gillis, Tammy; Wakimoto, Hiroko; Seidman, Jonathan; MacDonald, Marcy E.; Cotman, Susan; Gailus-Durner, Valérie; Fuchs, Helmut; de Angelis, Martin Hrabě; Lee, Jong-Min; Wheeler, Vanessa C. (Public Library of Science, 2013)
      Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in the HTT gene encoding huntingtin. The disease has an insidious course, typically ...

    • Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity 

      Guilinger, John P.; Pattanayak, Vikram; Reyon, Deepak; Tsai, Shengdar Q.; Sander, Jeffry D.; Joung, J. Keith; Liu, David R. (2014)
      Although transcription activator-like effector nucleases (TALENs) can be designed to cleave chosen DNA sequences, TALENs have been shown to have activity against related off-target sequences. To better understand TALEN ...

    • Broad Spectrum Antiangiogenic Treatment for Ocular Neovascular Diseases 

      Benny, Ofra; Nakai, Kei; Yoshimura, Takeru; Bazinet, Lauren; Akula, James Daniel; Nakao, Shintaro; Hafezi-Moghadam, Ali; Panigrahy, Dipak; Pakneshan, Pouya; D'Amato, Robert John (Public Library of Science, 2010)
      Pathological neovascularization is a hallmark of late stage neovascular (wet) age-related macular degeneration (AMD) and the leading cause of blindness in people over the age of 50 in the western world. The treatments focus ...

    • Broad targeting of angiogenesis for cancer prevention and therapy 

      Wang, Zongwei; Dabrosin, Charlotta; Yin, Xin; Fuster, Mark M.; Arreola, Alexandra; Rathmell, W. Kimryn; Generali, Daniele; Nagaraju, Ganji P.; El-Rayes, Bassel; Ribatti, Domenico; Chen, Yi Charlie; Honoki, Kanya; Fujii, Hiromasa; Georgakilas, Alexandros G.; Nowsheen, Somaira; Amedei, Amedeo; Niccolai, Elena; Amin, Amr; Ashraf, S. Salman; Helferich, Bill; Yang, Xujuan; Guha, Gunjan; Bhakta, Dipita; Ciriolo, Maria Rosa; Aquilano, Katia; Chen, Sophie; Halicka, Dorota; Mohammed, Sulma I.; Azmi, Asfar S.; Bilsland, Alan; Keith, W. Nicol; Jensen, Lasse D. (Academic Press, 2015)
      Deregulation of angiogenesis – the growth of new blood vessels from an existing vasculature – is a main driving force in many severe human diseases including cancer. As such, tumor angiogenesis is important for delivering ...