Now showing items 2127-2146 of 17255

    • Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo 

      Cullen, Valerie; Lindfors, Maria; Ng, Juliana; Paetau, Anders; Swinton, Erika; Kolodziej, Piotr; Boston, Heather; Saftig, Paul; Woulfe, John; Myllykangas, Liisa; Schlossmacher, Michael G; Tyynelä, Jaana; Feany, Mel B. (BioMed Central, 2009)
      Background: Elevated SNCA gene expression and intracellular accumulation of the encoded α-synuclein (aSyn) protein are associated with the development of Parkinson disease (PD). To date, few enzymes have been examined for ...
    • Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice 

      Sun, Jiusong; Sukhova, Galina K.; Zhang, Jie; Chen, Han; Sjoberg, Sara; Libby, Peter; Xia, Mingcan; Xiong, Na; Gelb, Bruce D.; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2011)
      Objective: Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions. Whether this protease participates directly ...
    • Cathepsin K knockout alleviates aging-induced cardiac dysfunction 

      Hua, Yinan; Robinson, Timothy J; Cao, Yongtao; Shi, Guo-Ping; Ren, Jun; Nair, Sreejayan (BlackWell Publishing Ltd, 2014)
      Aging is a major risk factor for cardiovascular disease. It has previously been shown that protein levels of cathepsin K, a lysosomal cysteine protease, are elevated in the failing heart and that genetic ablation of cathepsin ...
    • Cathepsin K Knockout Mitigates High-Fat Diet–Induced Cardiac Hypertrophy and Contractile Dysfunction 

      Hua, Yinan; Zhang, Yingmei; Dolence, Julia; Shi, Guo-Ping; Ren, Jun; Nair, Sreejayan (American Diabetes Association, 2013)
      The cysteine protease cathepsin K has been implicated in pathogenesis of cardiovascular disease. We hypothesized that ablation of cathepsin K protects against obesity-associated cardiac dysfunction. Wild-type mice fed a ...
    • Cathepsin K-mediated notch1 activation contributes to neovascularization in response to hypoxia 

      Jiang, Haiying; Wu Cheng, Xian; Shi, Guo-Ping; Hu, Lina; Inoue, Aiko; Yamamura, Yumiko; Wu, Hongxian; Takeshita, Kyosuke; Li, Xiang; Huang, Zhe; Song, Haizhen; Asai, Masashi; Hao, Chang-Ning; Unno, Kazumasa; Koike, Teruhiro; Oshida, Yoshiharu; Okumura, Kenji; Murohara, Toyoaki; Kuzuya, Masafumi (Nature Research (part of Springer Nature), 2014)
      Cysteine proteases play important roles in pathobiology. Here we reveal that cathepsin K (CatK) has a role in ischaemia-induced neovascularization. Femoral artery ligation-induced ischaemia in mice increases CatK expression ...
    • Cathepsin L Activity Is Essential to Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice 

      Sun, Jiusong; Sukhova, Galina K.; Zhang, Jie; Chen, Han; Sjoberg, S.; Libby, Peter; Xiang, M.; Wang, J.; Peters, C.; Reinheckel, T.; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2011)
      Objective—The development of abdominal aortic aneurysms (AAA) requires extensive aortic wall matrix degradation. Human AAA lesions express high levels of cathepsin L (CatL), one of the most potent mammalian elastases. ...
    • Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells 

      Liu, Jian; Sukhova, Galina K.; Yang, Jin-Tian; Sun, Jiusong; Ma, Likun; Ren, An; Xu, Wei-Hua; Fu, Huanxiang; Dolganov, Gregory M.; Hu, Chengcheng; Libby, Peter; Shi, Guo-Ping (Elsevier BV, 2006)
      The cysteine protease cathepsin L is one of the most potent mammalian elastases and collagenases, widely expressed at basal levels in most tested tissues and cell types, and regulated by pro-inflammatory stimuli. The ...
    • Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K−Akt/p-HDAC6 Signaling Pathway 

      Wu, Hongxian; Cheng, Xian Wu; Hu, Lina; Takeshita, Kyosuke; Hu, Chen; Du, Qiuna; Li, Xiang; Zhu, Enbo; Huang, Zhe; Yisireyili, Maimaiti; Zhao, Guangxian; Piao, Limei; Inoue, Aiko; Jiang, Haiying; Lei, Yanna; Zhang, Xiaohong; Liu, Shaowen; Dai, Qiuyan; Kuzuya, Masafumi; Shi, Guo-Ping; Murohara, Toyoaki (Lippincott Williams & Wilkins, 2016)
      Objective— Cathepsin S (CatS) participates in atherogenesis through several putative mechanisms. The ability of cathepsins to modify histone tail is likely to contribute to stem cell development. Histone deacetylase 6 ...
    • Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors 

      Wang, Bing; Sun, Jiusong; Kitamoto, Shiro; Yang, Min; Grubb, Anders; Chapman, Harold A.; Kalluri, Raghu; Shi, Guo-Ping (American Society for Biochemistry and Molecular Biology, 2006)
      The cysteine protease cathepsin S is highly expressed in malignant tissues. By using a mouse model of multistage murine pancreatic islet cell carcinogenesis in which cysteine cathepsin activity has been functionally ...
    • Cathepsin S Signals via PAR2 and Generates a Novel Tethered Ligand Receptor Agonist 

      Elmariah, Sarina B.; Reddy, Vemuri B.; Lerner, Ethan A. (Public Library of Science, 2014)
      Protease-activated receptor-2 is widely expressed in mammalian epithelial, immune and neural tissues. Cleavage of PAR2 by serine proteases leads to self-activation of the receptor by the tethered ligand SLIGRL. The ...
    • Cathepsin S Supports Acid-independent Infection by Some Reoviruses 

      Golden, Joseph W.; Bahe, Jessica A.; Lucas, William T.; Nibert, Max L.; Schiff, Leslie A. (American Society for Biochemistry and Molecular Biology, 2004)
    • The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach 

      Binder, Alexandra M; Michels, Karin B (BioMed Central, 2013)
      Background: Investigation of the biological mechanism by which folate acts to affect fetal development can inform appraisal of expected benefits and risk management. This research is ethically imperative given the ubiquity ...
    • Causal inference as an emerging statistical approach in neurology: an example for epilepsy in the elderly 

      Moura, Lidia MVR; Westover, M Brandon; Kwasnik, David; Cole, Andrew J; Hsu, John (Dove Medical Press, 2017)
      The elderly population faces an increasing number of cases of chronic neurological conditions, such as epilepsy and Alzheimer’s disease. Because the elderly with epilepsy are commonly excluded from randomized controlled ...
    • Causal Influence of Articulatory Motor Cortex on Comprehending Single Spoken Words: TMS Evidence 

      Schomers, Malte R.; Kirilina, Evgeniya; Weigand, Anne; Bajbouj, Malek; Pulvermüller, Friedemann (Oxford University Press, 2014)
      Classic wisdom had been that motor and premotor cortex contribute to motor execution but not to higher cognition and language comprehension. In contrast, mounting evidence from neuroimaging, patient research, and transcranial ...
    • Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome 

      Day, Felix R.; Hinds, David A.; Tung, Joyce Y.; Stolk, Lisette; Styrkarsdottir, Unnur; Saxena, Richa; Bjonnes, Andrew; Broer, Linda; Dunger, David B.; Halldorsson, Bjarni V.; Lawlor, Debbie A.; Laval, Guillaume; Mathieson, Iain; McCardle, Wendy L.; Louwers, Yvonne; Meun, Cindy; Ring, Susan; Scott, Robert A.; Sulem, Patrick; Uitterlinden, André G.; Wareham, Nicholas J.; Thorsteinsdottir, Unnur; Welt, Corrine; Stefansson, Kari; Laven, Joop S. E.; Ong, Ken K.; Perry, John R. B. (Nature Pub. Group, 2015)
      Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women, yet there is little consensus regarding its aetiology. Here we perform a genome-wide association study of PCOS in up to 5,184 self-reported ...
    • Causal Relationship Between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts 

      Vimaleswaran, Karani S.; Berry, Diane J.; Lu, Chen; Tikkanen, Emmi; Pilz, Stefan; Hiraki, Linda T; Cooper, Jason D.; Dastani, Zari; Li, Rui; Houston, Denise K.; Wood, Andrew R.; Michaëlsson, Karl; Vandenput, Liesbeth; Zgaga, Lina; Yerges-Armstrong, Laura M.; McCarthy, Mark I.; Dupuis, Josée; Kaakinen, Marika; Kleber, Marcus E.; Jameson, Karen; Arden, Nigel; Raitakari, Olli; Viikari, Jorma; Lohman, Kurt K.; Ferrucci, Luigi; Melhus, Håkan; Ingelsson, Erik; Byberg, Liisa; Lind, Lars; Lorentzon, Mattias; Salomaa, Veikko; Campbell, Harry; Dunlop, Malcolm; Mitchell, Braxton D.; Herzig, Karl-Heinz; Pouta, Anneli; Hartikainen, Anna-Liisa; Streeten, Elizabeth A.; Theodoratou, Evropi; Jula, Antti; Wareham, Nicholas J.; Ohlsson, Claes; Frayling, Timothy M.; Kritchevsky, Stephen B.; Spector, Timothy D.; Richards, J. Brent; Lehtimäki, Terho; Ouwehand, Willem H.; Kraft, Peter; Cooper, Cyrus; März, Winfried; Power, Chris; Loos, Ruth J. F.; Wang, Thomas Jue-Fuu; Järvelin, Marjo-Riitta; Whittaker, John C.; Hingorani, Aroon D.; Hyppönen, Elina; Genetic Investigation of Anthropometric Traits (GIANT) consortium (Public Library of Science, 2013)
      Background: Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin ...
    • The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study 

      Carreras-Torres, Robert; Haycock, Philip C.; Relton, Caroline L.; Martin, Richard M.; Smith, George Davey; Kraft, Peter; Gao, Chi; Tworoger, Shelley; Le Marchand, Loïc; Wilkens, Lynne R.; Park, Sungshim L.; Haiman, Christopher; Field, John K.; Davies, Michael; Marcus, Michael; Liu, Geoffrey; Caporaso, Neil E.; Christiani, David C.; Wei, Yongyue; Chen, Chu; Doherty, Jennifer A.; Severi, Gianluca; Goodman, Gary E.; Hung, Rayjean J.; Amos, Christopher I.; McKay, James; Johansson, Mattias; Brennan, Paul (Nature Publishing Group, 2016)
      Body mass index (BMI) is inversely associated with lung cancer risk in observational studies, even though it increases the risk of several other cancers, which could indicate confounding by tobacco smoking or reverse ...
    • Cause of Death and Predictors of All‐Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF 

      Pokorney, Sean D.; Piccini, Jonathan P.; Stevens, Susanna R.; Patel, Manesh R.; Pieper, Karen S.; Halperin, Jonathan L.; Breithardt, Günter; Singer, Daniel E.; Hankey, Graeme J.; Hacke, Werner; Becker, Richard C.; Berkowitz, Scott D.; Nessel, Christopher C.; Mahaffey, Kenneth W.; Fox, Keith A. A.; Califf, Robert M.; Anderson, J.; Bedwell, N.; Bilsker, M.; Bruce, G.; Agah, R.; DeSantis, M.; Eisenberg, S.; Flores, A.; Herzog, W.; Klein, S.; Snyder, H.; Krueger, S.; Almaguer, E.; Lavie, E.; Lee, C.; Mallis, G.; Modi, M.; Woodworth, G.; Niazi, I.; Peart, B.; Sundaram, S.; Snoddy, B.; Sotolongo, R.; Moloney, J.; Vijayaraghavan, K.; Whittier, F.; Yellen, L.; Banerjee, S.; Lustgarten, D.; Suresh, D.; Gelernt, M.; Levinson, L.; Ghanekar, R.; Kneller, G.; Hall, C.; Fadl, Y.; Pirwitz, M.; French, W.; Mayer, N.; Pugeda, J.; Steel, K.; Mody, F.; Malik, A.; Chandna, H.; Go, A.; Emlein, G.; Bowden, W.; Moscoso, R.; Hodson, R.; Berk, M.; Pan, D.; Pappas, J.; Orchard, R.; Lynchard, G.; Vijay, N.; Khan, W.; El Khadra, M; Antonishen, M.; Cucher, F.; Staab, M.; Zebrack, J.; Borromeo, S; Heilman, J.; Chaturvedi, S.; Makam, S.; Turk, S.; Hyers, T.; Williams, G.; Labroo, A.; Gill, S.; Myears, D.; Weinstein, J.; Shanes, J.; Chandrashekhar, Y.; Shah, S.; Reiter, W.; Logemann, T.; Almquist, A.; Bhagwat, R.; Tak, T.; Shen‐Ling, J.; Patel, P.; Artis, A.; Arouni, A.; Lauer, M.; Kinney, K.; Elsen, J.; Roan, P.; Villafria, R.; Sumpter, M.; Ip, J.; Welka, S.; Schifferdecker, B.; Sandoval, R.; Speirs, S.; Jones, A.; Haldis, T.; Kazmierski, J.; Sutherland, J.; Dietrich, D.; Telfer, E.; Berry, J.; McElveen, A.; Russell, J.; Sackett, M.; Antonios, N.; Smith, D.; Vora, K.; Kirby, A.; Lui, H.; Mego, D.; Ziada, K.; Navas, J.; Taussig, A.; Koren, M.; Vogel, C.; Saba, F.; Parrott, C.; Schneider, R.; Shirwany, A.; Rubin, M.; Treasure, C; Bertolet, B.; Chang, M.; Langberg, J.; Becker, R.; Cohen, Y.; McGrew, F.; White, J.; Arzola, F.; Zelenka, J.; Tannenbaum, A.; Fernandes, V.; Jamnadas, P.; Agamasu, J.; Collins, B.; Jauch, W.; Sasseen, B.; Hotchkiss, D.; Abadier, R.; Osunkoya, A.; Schlau, A.; Chappel, C.; Foster, M.; Braun, E.; Mostel, E.; Capo, J.; Ashchi, M.; Howard, V.; Albirini, A.; Burger, A.; Rolston, D.; Staniloae, C.; Bacon, J.; Wiseman, A.; McGarvey, J; Sonel, A.; Hamroff, G.; Chang, D.; Daboul, N.; Broderick, G.; Meholick, A.; Corbelli, J.; Silverman, R.; Raffetto, J.; Fishberg, R.; Georgeson, S.; Held, J.; Seidner, M.; Saint‐Jacques, H.; Heitner, J.; Kutalek, S.; Friedlander, I.; Hutchinson, B.; Walia, J.; Kondo, N.; Smiley, N.; Blitz, L.; Dale, H.; Sulman, S.; Szulawski, I.; Modares, F.; Martin, R.; Nahhas, A.; Renzi, M.; Akyea‐Djamson, A.; Alfieri, A.; Sandhu, J.; Voyce, S.; Amaram, S.; Meyerrose, G.; Shoukfeh, M.; Lee, F.; Villegas, B.; Idowu, O.; Khera, A.; Sam, C.; Vo, A.; Lieber, I.; Smith, T.; Awan, N.; Tsai, C.; Ganim, R.; Alzaghrini, G.; Pitt, W.; Shepherd, A.; Tang, S.; Stoltz, S.; Nelson, W.; Cox, S.; Meymandi, S.; Melucci, M.; Thomas, G.; Gogia, H.; Machell, C.; Chandrasekaran, S.; Brown, C.; Jetty, P.; Miller, G.; Dykstra, G.; Jaffrani, N.; Zakhary, B.; Caruso, A.; Zolty, R.; Fox, D.; Jacobs, G.; Lebenthal, M.; Mukherjee, S.; Zimetbaum, P.; Kingsley, J.; Jones, R.; Robinson, V.; Kenton, D.; Usedom, J.; Williams, S.; Snipes, C.; Wilson, V.; Hasty, R.; Shoemaker, J.; Donahue, M.; Al‐Saghir, Y.; Thomsen, E.; Yarows, S.; Chastain, S.; McLaughlin, P.; Wakham, M.; Shrestha, D.; Simmons, J.; Fisher, D.; Seymour, Z.; Frandsen, B.; First, B.; Sharpe, C.; Popeil, L.; Guthrie, R.; Hunter, J.; Alvarado, O.; Sandberg, J.; Gutman, N.; Belber, A.; Arkhipov, M.; Ballyzek, M.; Baranov, A.; Barbarash, O.; Barbarich, V.; Belenky, D.; Berkovich, O.; Bokarev, I.; Boyarkin, M.; Vaniev, S.; Volkova, E.; Gratsiansky, N.; Demin, A.; Zadionchenko, V.; Zateyshchikov, D.; Zrazhevsky, K.; Mazaev, V.; Martynov, A.; Mikhailov, S.; Mkrtchian, V.; Novozhenov, V.; Raskina, T.; Rebrov, A.; Sanina, N.; Simanekov, V.; Sitnikova, M.; Smolenskaya, O.; Stryuk, R.; Storozhakov, G.; Tankhilevich, B.; Tereschenko, S.; Khokhlov, A.; Khrustalev, O.; Chernov, S.; Shvarts, Y.; Shubik, Y.; Shulman, V.; Yakushin, S.; Bugrova, O.; Ivleva, A.; Libis, R.; Khozyainova, N.; Maslov, S.; Baranova, E.; Sherenkov, A.; Libov, I.; Lusov, V.; Chumakova, G.; Kuznetsov, V.; Ryamzina, I.; Reshetko, O.; Boldueva, S.; Alekseeva, N.; Novikova, T.; Dvornikov, V.; Idrisova, E.; Shostak, N.; Yarokhno, N.; Tebloev, K.; Treshkur, T.; Mazurov, V.; Loktin, E.; Sedavnyh, I.; Alexeeva, O.; Yakhontova, P.; Repin, A.; Izmozherova, N.; Kostenko, V.; Fokin, A.; Ketova, G.; Kouz, S.; Leader, R.; Ayala‐Paredes, F.; Luton, R.; Ma, P.; Pandey, S.; Pesant, Y.; Senior, R.; Vertes, G.; Bell, A.; Crowley, D.; Vizel, S.; Lasko, B.; Landry, D.; Berger, L.; Heath, J.; Bessoudo, R.; Ling, M.; Tellier, G.; Berlingieri, J.; Kafka, H.; Hill, L.; Mazza, G.; O'Mahony, W.; Chilvers, M.; O'Mahony, M.; Newman, D.; Silagy, S.; Heffernan, M.; Bennett, M.; Bhesania, T.; Rockman, G.; Ng, K.; Kalra, B.; Meneses, G.; Liang, W.; Cheung, M.; Kozak, J.; Pugen, G.; Vavougios, J.; Kates, M.; Nunes‐Vaz, C.; Jaffer, S.; Orfi, J.; Faiers, A.; Chung, C.; Felsen, S.; Bergman, S.; Bernstein, I.; Brownscombe, L.; Stockdill, J.; Silver, E.; Ezekiel, D.; Jagan, N.; Khurana, M.; Reisler, H.; Goldman, H.; Maung, T.; Wong, F.; Gillis, G.; Vexler, R.; Goldberg, B.; Luterman, M.; Gould, D.; Coutu, B.; Ouellet, A.; MacDonald, P.; Jones, M.; Collette, R.; Chong, P.; Fargher, T.; St‐Maurice, F.; Fortin, C.; Chehayeb, R.; Proulx, G.; Roy, R.; Liutkus, J.; Syan, G.; Rupka, D.; Lichtenstein, T.; Kooy, J.; Papastergiou, D.; Lubelsky, B.; Doyle, W.; Rajakumar, A.; Cha, J.; Choudhry, A.; Bhamjee, H.; Mawji, A.; Durfresne, M.; Constance, C.; Mutrie, J.; Najarali, A.; Warren, R.; Mucha, M.; Borts, D.; Nord, P.; Carrier, S.; Dawood, M.; Sabe‐Affaki, G.; Archibald, J.; Abram, N.; Teitelbaum, E.; Ebrahim, I.; Siebert, R.; van Zyl, L.; Theron, H.; Lloyd, E.; Sommers, R.; Podgorski, G.; Steingo, L.; Dalby, A.; Bayat, J.; Herbst, L.; Bester, F.; Corbett, C.; Bennett, J.; Roodt, A.; Roux, J.; Abelson, M.; Mohamed, Z.; Nortje, H.; Da Silva, A.; Nikolaides, K.; Liagkas, K.; Papasteriadis, E.; Achimastos, A.; Koliopoulos, N.; Trikas, A.; Manolis, A.; Ruiter, J.; Basart, D.; Crijns, H.; Withagen, A.; Janssen, M.; Van Langeveld, R; van Gelder, I.; Hamer, B.; Van Der Heijden, R; Hertzeberger, D.; Van Hessen, M; Pieterse, M.; Groutars, R.; Kuijper, A.; De Ruiter, G; van Boven, A.; Hoogslag, P.; Kragten, H.; Thijssen, H.; Veldkamp, R.; Scavee, C.; Heidbuchel, H.; Debruyne, P.; Deruyter, B.; El Ali, H; Goethals, M.; Cytryn, R.; Striekwold, H.; De Wolf, L; Goethals, P.; Provenier, F.; Hellemans, S.; Galinier, M.; Coisne, D.; Koenig, A.; Galley, D.; Destrac, S.; Leduc, J.; Rifai, A.; Citron, B.; Ellie, E.; Fournier, P.; Steg, G.; Landel, R.; Robinson, A.; Ziegler, F.; Boulliat, J.; Zuber, M.; Vida, M.; Galve Basilio, E.; Lopez, M.; Íñiguez, C.; Iglesias Alonso, L.; Cavero Gibanel, M.; Olivan Martinez, J.; Calvo Iglesias, F.; Marco Vera, P.; Bruguera Cortada, J.; Jaber Houbani, A.; Merino, J.; Olaz Preciado, F.; Balaguer, J.; de la Hera Galarza, J; Martinez Rubio, A.; Fontcuberta, J.; Sotillo Marti, J.; Gonzalez Juanatey, J.; Del Campo, R.; Vivanco, G.; Alvarez Garcia, P.; Pelayo, M.; Lippai, J.; Zamolyi, K.; Károly, T.; Vertes, A.; Nagy, A.; Kosa, I.; Janosi, A.; Lupkovics, G.; Kalo, E.; Forster, T.; Kis, E.; Tenczer, J.; Bereczki, D.; Komoly, S.; Csanyi, A.; Kiss, R.; Valikovics, A.; Dioszeghy, P.; Masini, F.; Terrosu, P.; Cirrincione, V.; Marabotti, C.; Cosmi, F.; Salvioni, A.; Binetti, G.; Piovaccari, G.; Nassiacos, D.; Boriani, G.; Calvi, V.; De Caterina, R; Pengo, V.; Parati, G.; Carolei, A.; D'Angelo, A.; Di Biase, M.; Fattore, L.; Agnelli, G.; Merlini, P.; Furlan, M.; Rasura, M.; Gandolfo, C.; Ageno, W.; Piovella, F.; Micieli, G.; Cinteza, M.; Fierbinteanu, C.; Natase‐Melicovici, D.; Ionescu, D.; Macarie, C.; Nanea, I.; Radoi, M.; Tatu‐Chitoiu, G.; Dragulescu, S.; Tudose, A.; Militaru, C.; Bengus, C.; Ungureanu, G.; Tau, A.; Popa, V.; Pirvu, O.; Bojinca, M.; Sipciu, D.; Popescu, M.; Chiru, M.; Vinereanu, D.; Tudoran, M.; Cojocaru, T.; Vintila, M.; Aron, G.; Petrascu, O.; Bolohan, F.; Baumgartner, R.; Sekoranja, L.; Vojacek, J.; Lacnak, B.; Kellnerova, I.; Dunaj, M.; Cihalik, C.; Janota, T.; Janousek, J.; Bouchal, P.; Spacek, R.; Choi Siruckova, J.; Heinc, P.; Vojtisek, P.; Pirchala, M.; Malecha, J.; Padour, F.; Linhart, A.; Mandysova, E.; Jandik, J.; Zidkova, E.; Sipula, D.; Ostadal, P.; Polasek, R.; Stransky, V.; Marcinek, G.; Rysava, D.; Osmancik, P.; Huber, K.; Drexel, H.; Brainin, M.; Eichinger‐Hasenauer, S.; Lang, W.; Pilger, E.; Moriarty, A.; Hudson, I.; Tang, K.; Cleland, J.; MacWalter, R.; Cooke, J.; McInnes, G.; Durairaj, R.; MacLeod, M.; Murdoch, D.; Kadr, H.; Lip, G.; Andrews, R.; Hunt, B.; Jackson, P.; Roffe, C.; Syed, H.; Bath, P.; Coyle, J.; Kelly, D.; Stender, S.; TorpPedersen, C.; Tuxen, C.; Jensen, G.; Melchior, T.; Klarlund, K.; Dahlstrom, C.; Nielsen, T.; Nielsen, E.; Bronnum‐Schou, J.; Sykulski, R.; Blomstrom, P.; Lindholm, C.; Wallen, T.; Nilsson, C.; Bertholds, E.; Carlsater, J.; Sirnes, P.; Elle, S.; Risberg, K.; Furuseth, K.; Skag, A.; Hoivik, H.; Landmark, N.; Kjaernli, T.; Berg‐Johansen, J.; Gradek, G.; Drzewiecki, A.; Pluta, W.; Szwed, H.; Trusz‐Gluza, M.; Ogorek, M.; Loboz‐Grudzien, K.; Ruszkowski, P.; Sciborski, R.; Kopaczewski, J.; Jaworska, K.; Kubica, J.; Opolski, G.; Hoffman, A.; Krzciuk, M.; Sinkiewicz, W.; Piotrowski, W.; Kolodziej, P.; Goszczynska, M.; Rynkiewicz, A.; Chojnowska, L.; Lewczuk, J.; Biedrzycka, M.; Piepiorka, M.; Kowal, J.; Karczmarczyk, A.; Pruszczyk, P.; Tendera, M.; Gaciong, Z.; Krzeminska‐Pakula, M.; Kornacewicz‐Jach, Z.; Kania, G.; Brachmann, J.; Lawall, H.; Guelker, H.; Spitzer, S.; MoebiusWinkler, S.; Dempfle, C.; Bode, C.; Darius, H.; Genth‐Zotz, S.; Sommer, S.; Roehnisch, J.; Strasser, R.; Daenschel, W.; Schwencke, C.; vom Dahl, J; Meuser, M.; Behrens‐Spandau, S.; Behrens‐Humbold, S.; Muegge, A.; Schoen, N.; Grooterhorst, P.; Ebert, H.; Kraemer, A.; Kohler, B.; Taggeselle, J.; Claus, G.; Sarnighausen, H.; Al‐Zoebi, A.; Schroeder, T.; Weissbrodt, M.; Lange, R.; Gabelmann, M.; Kaeaeb, S.; Doerr, M.; Boscher, D.; Bosch, R.; Sonntag, F.; Bauknecht, C.; Omran, H.; Leicht, M.; Veltkamp, R.; Hohensee, H.; Dieckmann, H.; Winkelmann, B.; Bernhardt, P.; Schnabel, A.; Kadel, C.; Proskynitopoulos, N.; Seidl, K.; Schellong, S.; Rios, C.; Guevara, C.; Coloma, R.; Torrejon, H.; Parra Galvan, J.; Drago Silva, J.; Gallegos, J.; Mendoza, A.; Negron, S.; Watanabe, L.; Medina, F.; Virgen Carrilo, L.; Alvarez Lopez, H.; Rodriguez, I.; Leiva‐Pons, J.; Baños Velasco, A.; Villarreal‐Careaga, J.; De los Rios, M; Gamba, M.; Llamas Esperon, G.; Villeda, E.; Ahuad Guerrero, A.; Alvariqueta, A.; Amuchastegui, M.; Bluguermann, J.; Caime, G.; Cuneo, C.; Gabito, A.; Garcia Brasca, D.; Hominal, M.; Jure, H.; Luquez, H.; Montana, O.; Piskorz, D.; Listorti, S.; Serra, J.; Sessa, H.; Varini, S.; Vita, N.; Aiub, J.; MacKinnon, I.; Chekherdemian, S.; Castagnino, J.; Cimbaro Canella, J.; Sgammini, H.; Escudero, A.; Albina, G.; Rapallo, C.; Balparda, C.; Chahin, M.; Fuentealba, V.; Riccitelli, M.; Casabe, J.; Lobo Marquez, L.; Kevorkian, R.; Cuadrado, J.; Dran, R.; Muntaner, J.; Gonzalez, M.; Cartasegna, L.; Hasbani, E.; Hrabar, A.; Sanchez, A.; Vogel, D.; Hershson, A.; Avezum, A.; Jaber, J.; Ernesto Leaes, P.; Bozza, A.; Lorga Filho, A.; Pimentel Filho, P.; Moura Jorge, J.; Maia, L.; Manenti, E.; D'Aurea Mora, R; de Souza Neto, J; Precoma, D.; Rabelo, A.; Rocha, J.; Rossi, P.; Kerr Saraiva, J.; Zimerman, L.; Bodanese, L.; Figueiredo, E.; de Souza, W. 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(John Wiley and Sons Inc., 2016)
      Background: Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all‐cause mortality may guide interventions. Methods and Results: In the Rivaroxaban ...
    • Cause-specific mortality in the unionized U.S. trucking industry 

      Laden, Francine; Hart, Jaime Elizabeth; Smith, Thomas J.; Davis, Mary E.; Garshick, Eric (National Institute of Environmental Health Sciences, 2007)
      Background: Occupational and population-based studies have related exposure to fine particulate air pollution, and specifically particulate matter from vehicle exhausts, to cardiovascular diseases and lung cancer. Objectives: ...
    • CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS variants 

      Spisak, Sandor; Lawrenson, Kate; Fu, Yanfang; Csabai, Istvan; Cottman, Rebecca T.; Haiman, Christopher; Han, Ying; Seo, Ji-Heui; Lenci, Romina; Li, Qiyuan; Tisza, Viktoria; Szallasi, Zoltan; Herbert, Zachery T.; Chabot, Matthew; Pomerantz, Mark; Solymosi, Norbert; Gayther, Simon; Joung, J. Keith; Freedman, Matthew L. (2016)
      The vast majority of disease-associated single nucleotide polymorphisms (SNPs) mapped by genome-wide association studies (GWAS) are located in the non-protein coding genome, but establishing the functional and mechanistic ...