Now showing items 2147-2166 of 17132

    • CC2D1A Regulates Human Intellectual and Social Function as well as NF-κB Signaling Homeostasis 

      Manzini, M. Chiara; Xiong, Lan; Shaheen, Ranad; Tambunan, Dimira E.; Di Costanzo, Stefania; Mitisalis, Vanessa; Tischfield, David J.; Cinquino, Antonella; Ghaziuddin, Mohammed; Christian, Mehtab; Jiang, Qin; Laurent, Sandra; Nanjiani, Zohair A.; Rasheed, Saima; Hill, R. Sean; Lizarraga, Sofia B.; Gleason, Danielle; Sabbagh, Diya; Salih, Mustafa A.; Alkuraya, Fowzan S.; Walsh, Christopher A. (2015)
      SUMMARY Autism spectrum disorder (ASD) and intellectual disability (ID) are often comorbid, but the extent to which they share common genetic causes remains controversial. Here, we present two autosomal-recessive “founder” ...
    • CCAAT/Enhancer Binding Protein β Is Dispensable for Development of Lung Adenocarcinoma 

      Cai, Yi; Hirata, Ayako; Nakayama, Sohei; VanderLaan, Paul A.; Levantini, Elena; Yamamoto, Mihoko; Hirai, Hideyo; Wong, Kwok-Kin; Costa, Daniel B.; Watanabe, Hideo; Kobayashi, Susumu S. (Public Library of Science, 2015)
      Lung cancer is the leading cause of cancer death worldwide. Although disruption of normal proliferation and differentiation is a vital component of tumorigenesis, the mechanisms of this process in lung cancer are still ...
    • CCAAT/Enhancer-Binding Protein \(\gamma\) Is a Critical Regulator of IL-1\(\beta\)-Induced IL-6 Production in Alveolar Epithelial Cells 

      Yan, Chunguang; Wang, Ximo; Cao, Jay; Wu, Min; Gao, Hongwei (Public Library of Science, 2012)
      CCAAT/enhancer binding protein \(\gamma\) (C/EBPγ) is a member of the C/EBP family of transcription factors, which lacks known activation domains. C/EBP\(\gamma\) was originally described as an inhibitor of C/EBP transactivation ...
    • CCAAT/Enhancer-Binding Protein Homologous (CHOP) Protein Promotes Carcinogenesis in the DEN-Induced Hepatocellular Carcinoma Model 

      Scaiewicz, Viviana; Nahmias, Avital; Chung, Raymond T.; Mueller, Tobias; Tirosh, Boaz; Shibolet, Oren (Public Library of Science, 2013)
      Background and Aims C/EBP homologous protein (CHOP) plays pro-apoptotic roles in the integrated stress response. Recently, a tumor suppressive role for CHOP was demonstrated in lung cancer via regulation of tumor metabolism. ...
    • Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53 

      Sorrells, Shelly; Carbonneau, Seth; Harrington, Erik; Chen, Aye T.; Hast, Bridgid; Milash, Brett; Major, Michael B.; Stewart, Rodney A.; Jette, Cicely; Pyati, Ujwal Jagdeesh; Zon, Leonard Ira; Look, A. Thomas; Zhou, Yi (Public Library of Science, 2012)
      DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought ...
    • CCL-21 Conditioned Regulatory T Cells Induce Allotolerance through Enhanced Homing to Lymphoid Tissue 

      Chauhan, Sunil Kumar; Saban, Daniel R.; Dohlman, Thomas H.; Dana, Reza (The American Association of Immunologists, 2013)
      Regulatory T cells (Tregs) are instrumental in the induction and maintenance of tolerance, including in transplantation. Tregs induce allotolerance by interacting with antigen-presenting cells (APC) and T cells, interactions ...
    • CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function 

      Chun, Eunyoung; Lavoie, Sydney; Michaud, Monia; Gallini, Carey Ann; Kim, Jason; Soucy, Genevieve; Odze, Robert; Glickman, Jonathan N.; Garrett, Wendy S. (2015)
      Summary Our study reveals a non-canonical role for CCL2 in modulating non-macrophage, myeloid-derived suppressor cells (MDSCs) and shaping a tumor-permissive microenvironment during colon cancer development. We found that ...
    • CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice 

      Chen, Xuguang; Wang, Yunyue; Nelson, David; Tian, Sara; Mulvey, Erin; Patel, Bhumi; Conti, Ilaria; Jaen, Juan; Rollins, Barrett J. (Public Library of Science, 2016)
      Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear. Here we report ...
    • CCN1 Secretion Induced by Cigarette Smoking Extracts Augments IL-8 Release from Bronchial Epithelial Cells 

      Moon, Hyung-Geun; Zheng, Yijie; An, Chang Hyeok; Kim, Yoon-Keun; Jin, Yang (Public Library of Science, 2013)
      Inflammation involves in many cigarette smoke (CS) related diseases including the chronic obstructive pulmonary disease (COPD). Lung epithelial cell released IL-8 plays a crucial role in CS induced lung inflammation. CS ...
    • CCR5 Chemokine Receptor Mediates Recruitment of MHC Class II-Positive Langerhans Cells in the Mouse Corneal Epithelium 

      Yamagami, Satoru; Hamrah, Pedram; Miyamoto, Kazuhisa; Miyazaki, Dai; Dekaris, Iva; Dawson, Tracey; Lu, Bao; Gerard, Craig; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2005)
      purpose. To characterize the chemokines and chemokine receptors that mediate the effect of proinflammatory cytokines, interleukin (IL)-1 and tumor necrosis factor (TNF)-α, on the recruitment of MHC class II+ Langerhans ...
    • CCR5 Is Essential for NK Cell Trafficking and Host Survival following Toxoplasma gondii Infection 

      Khan, Imtiaz A; Thomas, Seddon Y; Moretto, Magali M; Lee, Frederick S; Islam, Sabina A.; Combe, Crescent; Schwartzman, Joseph D; Luster, Andrew David (Public Library of Science, 2006)
      The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate ...
    • CCR6, the Sole Receptor for the Chemokine CCL20, Promotes Spontaneous Intestinal Tumorigenesis 

      Nandi, Bisweswar; Pai, Christine; Huang, Qin; Prabhala, Rao H.; Munshi, Nikhil C.; Gold, Jason S. (Public Library of Science, 2014)
      Interactions between the inflammatory chemokine CCL20 and its receptor CCR6 have been associated with colorectal cancer growth and metastasis, however, a causal role for CCL20 signaling through CCR6 in promoting intestinal ...
    • The CCR6/CCL20 Axis Mediates Th17 Cell Migration to the Ocular Surface in Dry Eye Disease 

      Dohlman, Thomas H.; Chauhan, Sunil Kumar; Kodati, Shilpa; Hua, Jing; Chen, Yihe; Omoto, Masahiro; Sadrai, Zahra; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2013)
      Purpose. Th17 cells are believed to be the primary effector cells in the pathogenesis of dry eye disease (DED). However, the mechanisms by which Th17 cells migrate from the lymphoid tissues to the ocular surface are ...
    • CCR7 Is Critical for the Induction and Maintenance of Th17 Immunity in Dry Eye Disease 

      Kodati, Shilpa; Chauhan, Sunil Kumar; Chen, Yihe; Dohlman, Thomas H.; Karimian, Parisa; Saban, Daniel; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2014)
      Purpose. We characterized antigen-presenting cell (APC)–relevant chemokine receptor expression in dry eye disease (DED), and investigated the effect of topical CC chemokine receptor (CCR)-7 blockade specifically on Th17 ...
    • CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells 

      Slater, Louise; Hett, Erik; Clatworthy, Anne; Mark, Kevin; Hung, Deborah (National Academy of Sciences, 2013)
      Bacterial toxins have evolved successful strategies for coopting host proteins to access the cytosol of host cells. Anthrax lethal factor (LF) enters the cytosol through pores in the endosomal membrane formed by anthrax ...
    • CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice 

      Felio, Kyrie; Nguyen, Hanh; Dascher, Christopher C.; Choi, Hak-Jong; Li, Sha; Zimmer, Michael I.; Colmone, Angela; Moody, D Branch; Brenner, Michael Barry; Wang, Chyung-Ru (Rockefeller University Press, 2009)
      Group 1 CD1 (CD1a, CD1b, and CD1c)–restricted T cells recognize mycobacterial lipid antigens and are found at higher frequencies in Mycobacterium tuberculosis (Mtb)–infected individuals. However, their role and dynamics ...
    • CD11b+ Migratory Dendritic Cells Mediate CD8 T Cell Cross-Priming and Cutaneous Imprinting after Topical Immunization 

      Nizza, Suzanne T.; Campbell, James J. (Public Library of Science, 2014)
      Topical antigen application is a focus of current vaccine research. This immunization route mimics natural antigen exposure across a barrier tissue and generates T cells imprinted for skin-selective homing. Soluble antigens ...
    • CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion 

      Zhou, Pengcheng; Erfani, Sonia; Liu, Zeyi; Jia, Changhe; Chen, Yecang; Xu, Bingwei; Deng, Xinyu; Alfáro, Jose E.; Chen, Li; Napier, Dana; Lu, Michael; Huang, Jian-An; Liu, Chunming; Thibault, Olivier; Segal, Rosalind; Zhou, Binhua P.; Kyprianou, Natasha; Horbinski, Craig; Yang, Xiuwei H. (Impact Journals LLC, 2015)
      Glioblastoma, one of the most aggressive forms of brain cancer, is featured by high tumor cell motility and invasiveness, which not only fuel tumor infiltration, but also enable escape from surgical or other clinical ...
    • CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling 

      Baldwin, Lauren A.; Hoff, John T.; Lefringhouse, Jason; Zhang, Michael; Jia, Changhe; Liu, Zeyi; Erfani, Sonia; Jin, Hongyan; Xu, Mei; She, Qing-Bai; van Nagell, John R.; Wang, Chi; Chen, Li; Plattner, Rina; Kaetzel, David M.; Luo, Jia; Lu, Michael; West, Dava; Liu, Chunming; Ueland, Fred R.; Drapkin, Ronny; Zhou, Binhua P.; Yang, Xiuwei H. (Impact Journals LLC, 2014)
      Human ovarian cancer is diagnosed in the late, metastatic stages but the underlying mechanisms remain poorly understood. We report a surprising functional link between CD151-α3β1 integrin complexes and the malignancy of ...
    • CD155/PVR Plays a Key Role in Cell Motility During Tumor Cell Invasion and Migration 

      Sloan, Kevin E; Eustace, Brenda K; Stewart, Jean K; Zehetmeier, Carol; Torella, Claudia; Simeone, Marina; Roy, Jennifer E; Unger, Christine; Ilag, Leodevico L; Jay, Daniel G; Louis, David Neil (BioMed Central, 2004)
      Background: Invasion is an important early step of cancer metastasis that is not well understood. Developing therapeutics to limit metastasis requires the identification and validation of candidate proteins necessary for ...