Now showing items 2187-2206 of 17137

    • CD43 gene expression is mediated by a nuclear factor which binds pyrimidine-rich single-stranded DNA 

      Farokhzad, Omid Cameron (Oxford University Press (OUP), 2000)
      CD43 is a leukocyte-specific surface molecule which plays an important role both in adhesion and signal transduction. We have identified a site spanning nucleotides +18 to +39 within the human CD43 gene promoter which in ...
    • CD44 is a direct target of miR-199a-3p and contributes to aggressive progression in osteosarcoma 

      Gao, Yan; Feng, Yong; Shen, Jacson K.; Lin, Min; Choy, Edwin; Cote, Gregory M.; Harmon, David C.; Mankin, Henry J.; Hornicek, Francis J.; Duan, Zhenfeng (Nature Publishing Group, 2015)
      Osteosarcoma is the most common primary bone malignancy in children and adolescents. Herein, we investigated the role of cluster of differentiation 44 (CD44), a cell-surface glycoprotein involved in cell-cell interactions, ...
    • CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis 

      Sosulski, Amanda; Horn, Heiko; Zhang, Lihua; Coletti, Caroline; Vathipadiekal, Vinod; Castro, Cesar M.; Birrer, Michael J.; Nagano, Osamu; Saya, Hideyuki; Lage, Kasper; Donahoe, Patricia K.; Pépin, David (Public Library of Science, 2016)
      CD44 is a transmembrane hyaluronic acid receptor gene that encodes over 100 different tissue-specific protein isoforms. The most ubiquitous, CD44 standard, has been used as a cancer stem cell marker in ovarian and other ...
    • CD46 Protects Against Chronic Obstructive Pulmonary Disease 

      Grumelli, Sandra; Lu, Bao; Peterson, Leif; Maeno, Toshitaka; Gerard, Craig John (Public Library of Science, 2011)
      Background: Chronic obstructive pulmonary disease and emphysema develops in 15% of ex-smokers despite sustained quitting, while 10% are free of emphysema or severe lung obstruction. The cause of the incapacity of the immune ...
    • CD54-NOTCH1 axis controls tumor initiation and cancer stem cell functions in human prostate cancer 

      Li, Chong; Liu, Shengwu; Yan, Ruping; Han, Ning; Wong, Kwok-Kin; Li, Lei (Ivyspring International Publisher, 2017)
      Cancer stem cells (CSCs) are considered one of the key contributors to chemoresistance and tumor recurrence. Therefore, the precise identification of reliable CSC markers and clarification of the intracellular signaling ...
    • CD8 T Cell Response and Evolutionary Pressure to HIV-1 Cryptic Epitopes Derived from Antisense Transcription 

      Bansal, Anju; Yan, Jiyu; Akinsiku, Olusimidele T.; Schaefer, Malinda; Sabbaj, Steffanie; Bet, Anne; Levy, David N.; Heath, Sonya; Tang, Jianming; Kaslow, Richard A.; Ndung’u, Thumbi; Heckerman, David; Hunter, Eric; Goepfert, Paul A.; Carlson, Jonathan Courtland; Walker, Bruce David; Goulder, Philip J. (The Rockefeller University Press, 2010)
      Retroviruses pack multiple genes into relatively small genomes by encoding several genes in the same genomic region with overlapping reading frames. Both sense and antisense HIV-1 transcripts contain open reading frames ...
    • CD8+ Lymphocytes Control Viral Replication in SIVmac239-Infected Rhesus Macaques without Decreasing the Lifespan of Productively Infected Cells 

      Klatt, Nichole R.; Shudo, Emi; Ortiz, Alex M.; Engram, Jessica C.; Paiardini, Mirko; Lawson, Benton; Else, James; Pandrea, Ivona; Estes, Jacob D.; Apetrei, Cristian; Ribeiro, Ruy M.; Perelson, Alan S.; Silvestri, Guido; Miller, Michael D.; Schmitz, Joern Engelbert (Public Library of Science, 2010)
      While CD8+ T cells are clearly important in controlling virus replication during HIV and SIV infections, the mechanisms underlying this antiviral effect remain poorly understood. In this study, we assessed the in vivo ...
    • CD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjects 

      Rodriguez, William Richard; Addo, Marylyn Martina; Rathod, Almas; Fitzpatrick, Cecily A; Yu, Xu; Perkins, Beth; Rosenberg, Eric Scott; Altfeld, Marcus; Walker, Bruce David (BioMed Central, 2004)
      Background: CD8+ T cell responses are known to be important to the control of HIV-1 infection. While responses to reverse transcriptase and most structural and accessory proteins have been extensively studied, CD8 T cell ...
    • CD8+ T-Cell Interleukin-7 Receptor Alpha Expression as a Potential Indicator of Disease Status in HIV-Infected Children 

      Sharma, Tanvi Shah; Hughes, Jane; Murillo, Amarylis; Riley, Joanne; Soares, Andreia; Little, Francesca; Mitchell, Charles D.; Hanekom, Willem A. (Public Library of Science, 2008)
      Background: Initiation and modification of antiretroviral therapy in HIV-infected children depend on viral load and CD4+ T-cell count. However, these surrogates have limitations, and complementary immunological markers to ...
    • CDC20 maintains tumor initiating cells 

      Xie, Qi; Wu, Qiulian; Mack, Stephen C.; Yang, Kailin; Kim, Leo; Hubert, Christopher G.; Flavahan, William A.; Chu, Chengwei; Bao, Shideng; Rich, Jeremy N. (Impact Journals LLC, 2015)
      Glioblastoma is the most prevalent and lethal primary intrinsic brain tumor. Glioblastoma displays hierarchical arrangement with a population of self-renewing and tumorigenic glioma tumor initiating cells (TICs), or cancer ...
    • Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner 

      Liu, Jia; Wan, Lixin; Liu, Jing; Yuan, Zhu; Zhang, Jinfang; Guo, Jianfeng; Malumbres, Marcos; Liu, Jiankang; Zou, Weiguo; Wei, Wenyi (Nature Publishing Group, 2016)
      Anaphase-promoting complex/cyclosome/Cdh1 is a multi-subunit ubiquitin E3 ligase that drives M to G1 cell cycle progression through primarily earmarking various substrates for ubiquitination and subsequent degradation by ...
    • CDX2 Expression in the Intestinal-Type Gastric Epithelial Neoplasia: Frequency and Significance. 

      Park, Do Youn; Srivastava, Amitabh; Kim, Gwang Ha; Mino-Kenudson, Mari; Deshpande, Vikram; Zukerberg, Lawrence R.; Song, Geum Am; Lauwers, Gregory Y. (Nature Publishing Group, 2010)
      CDX2 is an intestinal transcription factor responsible for regulating the proliferation and differentiation of intestinal epithelial cells. In gastric adenocarcinoma, CDX2 expression is known to be associated with limited ...
    • Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model 

      Bansal, Dimple; Scholl, Claudia; Fröhling, Stefan; McDowell, Elizabeth; Lee, Benjamin H.; Döhner, Konstanze; Ernst, Patricia; Davidson, Alan J.; Daley, George Q.; Zon, Leonard I.; Gilliland, D. Gary; Huntly, Brian P. (National Academy of Sciences, 2006)
      HOX genes have emerged as critical effectors of leukelmogenesis, but the mechanisms that regulate their expression in leukemia are not well understood. Recent data suggest that the caudal homeobox transcription factors ...
    • A Cdx4-Sall4 Regulatory Module Controls the Transition from Mesoderm Formation to Embryonic Hematopoiesis 

      Paik, Elizabeth J.; Mahony, Shaun; White, Richard M.; Price, Emily N.; DiBiase, Anthony; Dorjsuren, Bilguujin; Mosimann, Christian; Davidson, Alan J.; Gifford, David; Zon, Leonard I. (Elsevier, 2013)
      Summary Deletion of caudal/cdx genes alters hox gene expression and causes defects in posterior tissues and hematopoiesis. Yet, the defects in hox gene expression only partially explain these phenotypes. To gain deeper ...
    • CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells 

      Chen, Zhangguo; Chen, Lanfen; Olszak, Torsten; Zeissig, Sebastian; Kuo, Timothy T.; Mandelboim, Ofer; Beauchemin, Nicole; Lanier, Lewis L.; Baker, Kristi Dorothy; Huang, Yu-Hwa; Blumberg, Richard Steven (The Rockefeller University Press, 2011)
      Although carcinoembryonic antigen (CEA)–related cell adhesion molecule 1 (CEACAM1) has been viewed as a tumor suppressor, increasing clinical evidence shows that high levels of CEACAM1 expression on tumors correlates ...
    • CEACAM6 Gene Variants in Inflammatory Bowel Disease 

      Seiderer, Julia; Fries, Christoph; Tillack, Cornelia; Pfennig, Simone; Weidinger, Maria; Beigel, Florian; Lass, Ulrich; Wolf, Christiane; Lohse, Peter; Diegelmann, Julia; Czamara, Darina; Brand, Stephan; Glas, Jürgen; Göke, Burkhard; Ochsenkühn, Thomas; Müller-Myhsok, Bertram; Olszak, Torsten (Public Library of Science, 2011)
      Background: The carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) acts as a receptor for adherentinvasive E. coli (AIEC) and its ileal expression is increased in patients with Crohn’s disease (CD). Given ...
    • Ceftaroline Desensitization Procedure in a Pregnant Patient With Multiple Drug Allergies 

      Kuhlen, James L.; Blumenthal, Kimberly G.; Sokol, Caroline L.; Balekian, Diana S.; Weil, Ana A.; Varughese, Christy A.; Shenoy, Erica S.; Banerji, Aleena (Oxford University Press, 2015)
      Validated skin testing is lacking for many drugs, including ceftaroline. The cross-reactivity between ceftaroline and other β-lactam antibiotics is unknown. We report a case of a pregnant patient with cystic fibrosis and ...
    • Celebrity Suicides and Their Differential Influence on Suicides in the General Population: A National Population-Based Study in Korea 

      Myung, Woojae; Won, Hong-Hee; Fava, Maurizio; Mischoulon, David; Yeung, Albert; Lee, Dongsoo; Kim, Doh Kwan; Jeon, Hong Jin (Korean Neuropsychiatric Association, 2015)
      Objective: Although evidence suggests that there is an increase in suicide rates in the general population following celebrity suicide, the rates are heterogeneous across celebrities and countries. It is unclear which is ...
    • Celecoxib inhibits early cutaneous wound healing 

      Fairweather, Mark; Heit, Yvonne I.; Buie, Justin David; Rosenberg, Laura Michele; Briggs, Alexandra; Orgill, Dennis Paul; Bertagnolli, Monica Marie (Elsevier BV, 2015)
      BACKGROUND: Cyclooxygenase-2 (COX-2) is an inducible enzyme that is rapidly upregulated in response to injury, resulting in the production of prostaglandin E2 (PGE2), a primary mediator of inflammation and wound healing. ...
    • Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM) Study Design: Approach to the Future of Personalized Prevention of Celiac Disease 

      Leonard, Maureen M.; Camhi, Stephanie; Huedo-Medina, Tania B.; Fasano, Alessio (MDPI, 2015)
      In the past it was believed that genetic predisposition and exposure to gluten were necessary and sufficient to develop celiac disease (CD). Recent studies however suggest that loss of gluten tolerance can occur at any ...