Browsing HMS Scholarly Articles by Title
Now showing items 2244-2263 of 17922
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CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells
(Springer-Verlag, 2012)CD40L has a well-established role in enhancing the immunostimulatory capacity of normal and malignant B cells, but a formulation suitable for clinical use has not been widely available. Like other TNF family members, in ... -
CD43 gene expression is mediated by a nuclear factor which binds pyrimidine-rich single-stranded DNA
(Oxford University Press (OUP), 2000)CD43 is a leukocyte-specific surface molecule which plays an important role both in adhesion and signal transduction. We have identified a site spanning nucleotides +18 to +39 within the human CD43 gene promoter which in ... -
CD44 is a direct target of miR-199a-3p and contributes to aggressive progression in osteosarcoma
(Nature Publishing Group, 2015)Osteosarcoma is the most common primary bone malignancy in children and adolescents. Herein, we investigated the role of cluster of differentiation 44 (CD44), a cell-surface glycoprotein involved in cell-cell interactions, ... -
CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis
(Public Library of Science, 2016)CD44 is a transmembrane hyaluronic acid receptor gene that encodes over 100 different tissue-specific protein isoforms. The most ubiquitous, CD44 standard, has been used as a cancer stem cell marker in ovarian and other ... -
CD46 Protects Against Chronic Obstructive Pulmonary Disease
(Public Library of Science, 2011)Background: Chronic obstructive pulmonary disease and emphysema develops in 15% of ex-smokers despite sustained quitting, while 10% are free of emphysema or severe lung obstruction. The cause of the incapacity of the immune ... -
CD54-NOTCH1 axis controls tumor initiation and cancer stem cell functions in human prostate cancer
(Ivyspring International Publisher, 2017)Cancer stem cells (CSCs) are considered one of the key contributors to chemoresistance and tumor recurrence. Therefore, the precise identification of reliable CSC markers and clarification of the intracellular signaling ... -
CD73 Is a Phenotypic Marker of Effector Memory Th17 Cells in Inflammatory Bowel Disease
(Wiley, 2012-10-29)Purinergic signaling and associated ectonucleotidases, such as CD39 and CD73, have been implicated in the pathogenesis of inflammatory bowel disease (IBD). CD39 is known to be a Treg memory cell marker, and here we determine ... -
CD8 T Cell Response and Evolutionary Pressure to HIV-1 Cryptic Epitopes Derived from Antisense Transcription
(The Rockefeller University Press, 2010)Retroviruses pack multiple genes into relatively small genomes by encoding several genes in the same genomic region with overlapping reading frames. Both sense and antisense HIV-1 transcripts contain open reading frames ... -
CD8+ Lymphocytes Control Viral Replication in SIVmac239-Infected Rhesus Macaques without Decreasing the Lifespan of Productively Infected Cells
(Public Library of Science, 2010)While CD8+ T cells are clearly important in controlling virus replication during HIV and SIV infections, the mechanisms underlying this antiviral effect remain poorly understood. In this study, we assessed the in vivo ... -
CD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjects
(BioMed Central, 2004)Background: CD8+ T cell responses are known to be important to the control of HIV-1 infection. While responses to reverse transcriptase and most structural and accessory proteins have been extensively studied, CD8 T cell ... -
CD8+ T-Cell Interleukin-7 Receptor Alpha Expression as a Potential Indicator of Disease Status in HIV-Infected Children
(Public Library of Science, 2008)Background: Initiation and modification of antiretroviral therapy in HIV-infected children depend on viral load and CD4+ T-cell count. However, these surrogates have limitations, and complementary immunological markers to ... -
Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner
(Nature Publishing Group, 2016)Anaphase-promoting complex/cyclosome/Cdh1 is a multi-subunit ubiquitin E3 ligase that drives M to G1 cell cycle progression through primarily earmarking various substrates for ubiquitination and subsequent degradation by ... -
The CDK Inhibitor CR8 Acts as a Molecular Glue Degrader That Depletes Cyclin K
(Springer Science and Business Media LLC, 2020-06-03)Molecular glue compounds induce protein-protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation. Unlike traditional enzyme inhibitors, such molecular glue degraders act sub-stoichiometrically ... -
CDK8 Is a Colorectal Cancer Oncogene That Regulates β-Catenin Activity
(Springer Nature, 2008)Aberrant activation of the canonical Wnt/β-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated β-catenin activity drives colon tumorigenesis, ... -
CDX2 Expression in the Intestinal-Type Gastric Epithelial Neoplasia: Frequency and Significance.
(Nature Publishing Group, 2010)CDX2 is an intestinal transcription factor responsible for regulating the proliferation and differentiation of intestinal epithelial cells. In gastric adenocarcinoma, CDX2 expression is known to be associated with limited ... -
Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model
(National Academy of Sciences, 2006)HOX genes have emerged as critical effectors of leukelmogenesis, but the mechanisms that regulate their expression in leukemia are not well understood. Recent data suggest that the caudal homeobox transcription factors ... -
CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells
(The Rockefeller University Press, 2011)Although carcinoembryonic antigen (CEA)–related cell adhesion molecule 1 (CEACAM1) has been viewed as a tumor suppressor, increasing clinical evidence shows that high levels of CEACAM1 expression on tumors correlates ... -
CEACAM6 Gene Variants in Inflammatory Bowel Disease
(Public Library of Science, 2011)Background: The carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) acts as a receptor for adherentinvasive E. coli (AIEC) and its ileal expression is increased in patients with Crohn’s disease (CD). Given ... -
Ceftaroline Desensitization Procedure in a Pregnant Patient With Multiple Drug Allergies
(Oxford University Press, 2015)Validated skin testing is lacking for many drugs, including ceftaroline. The cross-reactivity between ceftaroline and other β-lactam antibiotics is unknown. We report a case of a pregnant patient with cystic fibrosis and ... -
Celebrity Suicides and Their Differential Influence on Suicides in the General Population: A National Population-Based Study in Korea
(Korean Neuropsychiatric Association, 2015)Objective: Although evidence suggests that there is an increase in suicide rates in the general population following celebrity suicide, the rates are heterogeneous across celebrities and countries. It is unclear which is ...