Browsing HMS Scholarly Articles by Title
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Dissociable Influences of Auditory Object vs. Spatial Attention on Visual System Oscillatory Activity
(Public Library of Science, 2012)Given that both auditory and visual systems have anatomically separate object identification (“what”) and spatial (“where”) pathways, it is of interest whether attention-driven cross-sensory modulations occur separately ... -
Dissociable Neural Mechanisms Underlying the Modulation of Pain and Anxiety? An fMRI Pilot Study
(Public Library of Science, 2014)The down-regulation of pain through beliefs is commonly discussed as a form of emotion regulation. In line with this interpretation, the analgesic effect has been shown to co-occur with reduced anxiety and increased activity ... -
Dissociated multimodal hubs and seizures in temporal lobe epilepsy
(BlackWell Publishing Ltd, 2015)Objective: Brain connectivity at rest is altered in temporal lobe epilepsy (TLE), particularly in “hub” areas such as the posterior default mode network (DMN). Although both functional and anatomical connectivity are ... -
The Dissociation between Early and Late Selection in Older Adults
(MIT Press - Journals, 2013)Older adults exhibit a reduced ability to ignore task-irrelevant stimuli; however, it remains to be determined where along the information processing stream the most salient age-associated changes occur. In the current ... -
Dissociation of Motor Task-Induced Cortical Excitability and Pain Perception Changes in Healthy Volunteers
(Public Library of Science, 2012)Background: There is evidence that interventions aiming at modulation of the motor cortex activity lead to pain reduction. In order to understand further the role of the motor cortex on pain modulation, we aimed to compare ... -
Distal esophageal carcinomas in Chinese patients vary widely in histopathology, but adenocarcinomas remain rare
(Elsevier BV, 2012)In Western countries, distal esophageal adenocarcinoma has outnumbered squamous cell carcinoma because of a dramatic increase in the prevalence of columnar-lined esophagus. Because the relative prevalence of these diseases ... -
Distal Pancreatic Resection for Neuroendocrine Tumors: Is Laparoscopic Really Better than Open?
(Springer US, 2015)Background: The latest studies on surgical and cost-analysis outcomes after laparoscopic distal pancreatectomy (LDP) highlight mixed and insufficient results. Whereas several investigators have compared surgical outcomes ... -
Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia
(Public Library of Science, 2010)Background: The architectural transcription factor High Mobility Group-A1 (HMGA1) binds to the minor groove of AT-rich DNA and forms transcription factor complexes (“enhanceosomes”) that upregulate expression of select ... -
Distance from Home to Study Clinic and Risk of Follow-Up Interruption in a Cohort of HIV-1-Discordant Couples in Nairobi, Kenya
(Public Library of Science, 2012)Background: Longitudinal studies of HIV-1-infected individuals or those at risk of infection are subject to missed study visits that may have negative consequences on the care of participants and can jeopardize study ... -
Distention of the Immature Left Ventricle Triggers Development of Endocardial Fibroelastosis: An Animal Model of Endocardial Fibroelastosis Introducing Morphopathological Features of Evolving Fetal Hypoplastic Left Heart Syndrome
(Hindawi Publishing Corporation, 2015)Background. Endocardial fibroelastosis (EFE), characterized by a diffuse endocardial thickening through collagen and elastin fibers, develops in the human fetal heart restricting growth of the left ventricle (LV). Recent ... -
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory
(The Rockefeller University Press, 2012)One component of memory in the antibody system is long-lived memory B cells selected for the expression of somatically mutated, high-affinity antibodies in the T cell–dependent germinal center (GC) reaction. A puzzling ... -
Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma
(Taylor & Francis, 2016)ABSTRACT We have made major advances in the treatment of melanoma through the use of targeted therapy and immune checkpoint blockade; however, clinicians are posed with therapeutic dilemmas regarding timing and sequence ... -
Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip
(Public Library of Science, 2016)Neurovascular inflammation is a major contributor to many neurological disorders, but modeling these processes in vitro has proven to be difficult. Here, we microengineered a three-dimensional (3D) model of the human ... -
Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis
(National Academy of Sciences, 2008)Mutations in the human DNA mismatch repair (MMR) gene MLH1 are associated with hereditary nonpolyposis colorectal cancer (Lynch syndrome, HNPCC) and a significant proportion of sporadic colorectal cancer. The inactivation ... -
Distinct Effects on Diversifying Selection by Two Mechanisms of Immunity Against Streptococcus pneumoniae
(Public Library of Science, 2012)Antigenic variation to evade host immunity has long been assumed to be a driving force of diversifying selection in pathogens. Colonization by Streptococcus pneumoniae, which is central to the organism's transmission and ... -
Distinct functional determinants of influenza hemagglutinin-mediated membrane fusion
(eLife Sciences Publications, Ltd, 2015)Membrane fusion is the critical step for infectious cell penetration by enveloped viruses. We have previously used single-virion measurements of fusion kinetics to study the molecular mechanism of influenza-virus envelope ... -
Distinct Functional Networks Within the Cerebellum and Their Relation to Cortical Systems Assessed With Independent Component Analysis
(Elsevier BV, 2012-05-01)Cerebellar functional circuitry has been examined in several prior studies using resting fMRI data and seed-based procedures, as well as whole-brain independent component analysis (ICA). Here, we hypothesized that ICA ... -
Distinct Malignant Behaviors of Mouse Myogenic Tumors Induced by Different Oncogenetic Lesions
(Frontiers Media S.A., 2015)Rhabdomyosarcomas (RMS) are heterogeneous cancers with myogenic differentiation features. The cytogenetic and mutational aberrations in RMS are diverse. This study examined differences in the malignant behavior of two ... -
Distinct Metabolomic Signatures Are Associated with Longevity in Humans
(2015)Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to ...