Now showing items 608-627 of 17917

    • Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia 

      Francis, Alan N; Seidman, Larry Joel; Jabbar, Gul A.; Mesholam-Gately, Raquelle; Thermenos, Heidi Wencel; Juelich, Richard; Proal, Ashley; Shenton, Martha Elizabeth; Kubicki, Marek R.; Mathew, Ian; Keshavan, Matcheri S; DeLisi, Lynn E (Elsevier BV, 2012)
      Introduction—Neuroanatomical and cognitive alterations typical of schizophrenia (SZ) patients are observed to a lesser extent in their adolescent and adult first-degree relatives, likely reflecting neurodevelopmental ...
    • Alterations in Brain-Derived Neurotrophic Factor in the Mouse Hippocampus Following Acute but Not Repeated Benzodiazepine Treatment 

      Licata, Stephanie C.; Shinday, Nina M.; Huizenga, Megan N.; Darnell, Shayna B.; Sangrey, Gavin R.; Rudolph, Uwe; Rowlett, James K.; Sadri-Vakili, Ghazaleh (Public Library of Science, 2013)
      Benzodiazepines (BZs) are safe drugs for treating anxiety, sleep, and seizure disorders, but their use also results in unwanted effects including memory impairment, abuse, and dependence. The present study aimed to reveal ...
    • Alterations in Corneal Stromal Dendritic Cell Phenotype and Distribution in Inflammation 

      Hamrah, Pedram; Liu, Ying; Zhang, Qiang; Dana, Reza (American Medical Association (AMA), 2003)
      Background The normal corneal stroma is endowed with large numbers of resident dendritic cells (DCs). The purpose of this study was to examine the phenotype and distribution of these cells in inflammation. Methods ...
    • Alterations in Energy/Redox Metabolism Induced by Mitochondrial and Environmental Toxins: A Specific Role for Glucose-6-Phosphate-Dehydrogenase and the Pentose Phosphate Pathway in Paraquat Toxicity 

      Lei, Shulei; Zavala-Flores, Laura; Garcia-Garcia, Aracely; Nandakumar, Renu; Huang, Yuting; Madayiputhiya, Nandakumar; Stanton, Robert C.; Dodds, Eric D.; Powers, Robert; Franco, Rodrigo (American Chemical Society, 2014)
      Parkinson’s disease (PD) is a multifactorial disorder with a complex etiology including genetic risk factors, environmental exposures, and aging. While energy failure and oxidative stress have largely been associated with ...
    • Alterations in gray matter volume due to unilateral hearing loss 

      Wang, Xingchao; Xu, Pengfei; Li, Peng; Wang, Zhenmin; Zhao, Fu; Gao, Zhixian; Xu, Lei; Luo, Yue-jia; Fan, Jin; Liu, Pinan (Nature Publishing Group, 2016)
      Although extensive research on neural plasticity resulting from hearing deprivation has been conducted, the direct influence of compromised audition on the auditory cortex and the potential impact of long durations of ...
    • Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia 

      Gascon, Eduardo; Lynch, Kelleen; Ruan, Hongyu; Almeida, Sandra; Verheyden, Jamie; Seeley, William W.; Dickson, Dennis W.; Petrucelli, Leonard; Sun, Danqiong; Jiao, Jian; Zhou, Hongru; Jakovcevski, Mira; Akbarian, Schahram; Yao, Wei-Dong; Gao, Fen-Biao (2014)
      Many neurodegenerative diseases, such as frontotemporal dementia (FTD), are associated with behavioral deficits, but the anatomical and molecular bases remain poorly understood. Here we show that forebrain-specific expression ...
    • Alterations of Serum Levels of BDNF-Related miRNAs in Patients with Depression 

      Li, You-Jie; Xu, Mei; Gao, Zong-Hua; Wang, Ya-Qi; Yue, Zhen; Zhang, Yan-Xia; Li, Xin-Xin; Zhang, Can; Xie, Shu-Yang; Wang, Ping-Yu (Public Library of Science, 2013)
      Depression is a serious and potentially life-threatening mental disorder with unknown etiology. Emerging evidence shows that brain-derived neurotrophic factor (BDNF) and microRNAs (miRNAs) play critical roles in the etiology ...
    • Alterations of the human gut microbiome in multiple sclerosis 

      Jangi, Sushrut; Gandhi, Roopali; Cox, Laura M.; Li, Ning; von Glehn, Felipe; Yan, Raymond; Patel, Bonny; Mazzola, Maria Antonietta; Liu, Shirong; Glanz, Bonnie L.; Cook, Sandra; Tankou, Stephanie; Stuart, Fiona; Melo, Kirsy; Nejad, Parham; Smith, Kathleen; Topçuolu, Begüm D.; Holden, James; Kivisäkk, Pia; Chitnis, Tanuja; De Jager, Philip L.; Quintana, Francisco J.; Gerber, Georg K.; Bry, Lynn; Weiner, Howard L. (Nature Publishing Group, 2016)
      The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis ...
    • Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth 

      Nemeth, Zsuzsanna; Csizmadia, Eva; Vikstrom, Lisa; Li, Mailin; Bisht, Kavita; Feizi, Alborz; Otterbein, Sherrie; Zuckerbraun, Brian; Costa, Daniel B.; Pandolfi, Pier Paolo; Fillinger, Janos; Döme, Balazs; Otterbein, Leo E.; Wegiel, Barbara (Impact Journals LLC, 2016)
      We hypothesized that tumor-associated macrophages (TAMs) are controlled by the diffusible gas carbon monoxide (CO). We demonstrate that induction of apoptosis in lung tumors treated with low doses of CO is associated with ...
    • Altered biochemical specificity of G-quadruplexes with mutated tetrads 

      Švehlová, Kateřina; Lawrence, Michael S.; Bednárová, Lucie; Curtis, Edward A. (Oxford University Press, 2016)
      A fundamental motif in canonical nucleic acid structure is the base pair. Mutations that disrupt base pairs are typically destabilizing, but stability can often be restored by a second mutation that replaces the original ...
    • Altered brain morphometry in carpal tunnel syndrome is associated with median nerve pathology☆☆☆ 

      Maeda, Yumi; Kettner, Norman; Sheehan, James; Kim, Jieun; Cina, Stephen; Malatesta, Cristina; Gerber, Jessica; McManus, Claire; Mezzacappa, Pia; Morse, Leslie R.; Audette, Joseph; Napadow, Vitaly (Elsevier, 2013)
      Objective: Carpal tunnel syndrome (CTS) is a common median nerve entrapment neuropathy characterized by pain, paresthesias, diminished peripheral nerve conduction velocity (NCV) and maladaptive functional brain neuroplasticity. ...
    • Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration 

      Chen, Jing; Smith, Lois Elaine Hodgson (Elsevier BV, 2013)
      Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ...
    • Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation 

      Ulirsch, Jacob C.; Lacy, Jessica N.; An, Xiuli; Mohandas, Narla; Mikkelsen, Tarjei S.; Sankaran, Vijay G. (Public Library of Science, 2014)
      Erythropoiesis is one of the best understood examples of cellular differentiation. Morphologically, erythroid differentiation proceeds in a nearly identical fashion between humans and mice, but recent evidence has shown ...
    • Altered Chromosomal Topology Drives Oncogenic Programs in SDH-Deficient GISTs 

      Flavahan, William A.; Drier, Yotam; Johnstone, Sarah E.; Hemming, Matthew; Tarjan, Daniel R.; Hegazi, Esmat; Shareef, Sarah; Javed, Nauman; Eschle, Benjamin K.; Gokhale, Prafulla C.; Hornick, Jason; Sicinska, Ewa; Demetri, George; Bernstein, Bradley (Springer Science and Business Media LLC, 2019-10-16)
      Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood1-3. A subset of gastrointestinal stromal tumors (GISTs) lack canonical kinase mutations but instead have ...
    • Altered Circadian Feeding Behavior and Improvement of Metabolic Syndrome in Obese Tac1-Deficient Mice 

      Maguire, Caroline; Leon, Silvia; Carroll, Rona; Kaiser, Ursula; Navarro, Victor (Springer Science and Business Media LLC, 2017-12)
      BACKGROUND Metabolic function is regulated by the interplay of central and peripheral factors that ultimately regulate food intake and energy expenditure. The tachykinin substance P (SP) has been identified as a novel ...
    • Altered distribution of mucosal NK cells during HIV infection 

      Sips, Magdalena; Sciaranghella, Gaia; Diefenbach, Thomas; Dugast, Anne-Sophie; Berger, Christoph T.; Liu, Qingquan; Kwon, Douglas; Ghebremichael, Musie; Estes, Jacob D.; Carrington, Mary; Martin, Jeffrey N.; Deeks, Steven G.; Hunt, Peter W.; Alter, Galit (2013)
      The human gut mucosa is a major site of HIV infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells play an important role in control of HIV infection but the mechanism(s) ...
    • Altered expression of norepinephrine transporter and norepinephrine in human placenta cause pre-eclampsia through regulated trophoblast invasion 

      Na, Kyu-Hwan; Choi, Jong Ho; Kim, Chun-Hyung; Kim, Kwang-Soo; Kim, Gi Jin (The Korean Society for Reproductive Medicine, 2013)
      Objective: We investigated the norepinephrine transporter (NET) expression in normal and pre-eclamptic placentas and analyzed the invasion activity of trophoblastic cells based on norepinephrine (NE)-NET regulation. Methods: ...
    • Altered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus 

      Chang, Hui-Hsin; Tseng, William; Cui, Jing; Costenbader, Karen; Ho, I-Cheng (BioMed Central, 2014)
      Introduction: A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human protein tyrosine phosphatase, non-receptor type 22 (PTPN22) complementary DNA (cDNA) is associated with an increased risk of ...
    • Altered Gene Expression Associated with microRNA Binding Site Polymorphisms 

      Võsa, Urmo; Esko, Tõnu; Kasela, Silva; Annilo, Tarmo (Public Library of Science, 2015)
      Allele-specific gene expression associated with genetic variation in regulatory regions can play an important role in the development of complex traits. We hypothesized that polymorphisms in microRNA (miRNA) response ...
    • Altered Gene Expression in Blood and Sputum in COPD Frequent Exacerbators in the ECLIPSE Cohort 

      Singh, Dave; Fox, Steven M.; Tal-Singer, Ruth; Bates, Stewart; Riley, John H.; Celli, Bartolome (Public Library of Science, 2014)
      Patients with chronic obstructive pulmonary disease (COPD) who are defined as frequent exacerbators suffer with 2 or more exacerbations every year. The molecular mechanisms responsible for this phenotype are poorly understood. ...