Browsing HMS Scholarly Articles by Title

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    • Fiscal difficulties of cities, the labor market, and health care 

      Hsu, John; Newhouse, Joseph; Overhage, Lindsay Nicole; Zuvekas, Samuel (Cambridge University Press (CUP), 2018-12-19)
      We investigated labor force and health outcomes in cities experiencing fiscal difficulties to assess how those difficulties might impact their employees. We matched 23 cities with bond downgrades and 31 cities with stable ...

    • FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution 

      Eames, B Frank; DeLaurier, April; Ullmann, Bonnie; Huycke, Tyler R; Nichols, James T; Dowd, John; McFadden, Marcie; Sasaki, Mark M; Kimmel, Charles B (BioMed Central, 2013)
      Background: The vertebrate craniofacial skeleton may exhibit anatomical complexity and diversity, but its genesis and evolution can be understood through careful dissection of developmental programs at cellular resolution. ...

    • The Fission Yeast COP9/signalosome Is Involved in Cullin Modification by Ubiquitin-related Ned8p 

      Zhou, Chunshui; Seibert, Volker; Geyer, Rory; Rhee, Edward; Lyapina, Svetlana; Cope, Greg; Deshaies, Raymond J; Wolf, Dieter A (BioMed Central, 2001)
      Background: The function of the fission yeast cullins Pcu1p and Pcu4p requires modification by the ubiquitin-related peptide Ned8p. A recent report by Lyapina et al. shows that the COP9/signalosome (CSN), a multifunctional ...

    • A Fit-Fat Index for Predicting Incident Diabetes in Apparently Healthy Men: A Prospective Cohort Study 

      Sloan, Robert A; Haaland, Benjamin A; Sawada, Susumu S; Lee, I-Min; Sui, Xuemei; Lee, Duck-chul; Ridouane, Yassine; Müller-Riemenschneider, Falk; Blair, Steven N (Public Library of Science, 2016)
      Background: The purpose of this study was to examine the impact of combined cardiorespiratory fitness and waist-to-height ratio in the form of a fit-fat index on incident diabetes risk. Additionally, the independent ...

    • A Fitness Index for Transplantation of Machine-Perfused Cadaveric Rat Livers 

      Tolboom, Herman; Perk, Sinem; Izamis, Maria Louisa; Uygun, Basak E.; Yarmush, Martin Leon; Uygun, Mustafa (BioMed Central, 2012)
      Background: The 110,000 patients currently on the transplant waiting list reflect the critical shortage of viable donor organs. However, a large pool of unused organs, from donors after cardiac death (DCD) that are ...

    • The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by In Vitro Testing 

      Mann, Jaclyn K.; Barton, John P.; Ferguson, Andrew L.; Omarjee, Saleha; Walker, Bruce D.; Chakraborty, Arup; Ndung'u, Thumbi (Public Library of Science, 2014)
      Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational model, rooted in physics, that aims to predict the fitness landscape ...

    • Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis 

      Alonso, Jose M.; Stepanova, Anna N.; Solano, Roberto; Wisman, Ellen; Ferrari, Simone; Ausubel, Frederick M.; Ecker, Joseph R. (National Academy of Sciences, 2003)
      Five ethylene-insensitive loci (wei1-wei5) were identified by using a low-dose screen for "weak" ethylene-insensitive mutants. wei1, wei2, and wei3 seedlings showed hormone insensitivity only in roots, whereas wei4 and ...

    • Five Features Of Value-Based Insurance Design Plans Were Associated With Higher Rates Of Medication Adherence 

      Choudhry, Niteesh Kumar; Fischer, Michael Adam; Smith, B. F.; Brill, G.; Girdish, C.; Matlin, O. S.; Brennan, Troyen Anthony; Avorn, Jerry Lewis; Shrank, W (Health Affairs (Project Hope), 2014)
      Value-based insurance design (VBID) plans selectively lower cost sharing to increase medication adherence. Existing plans have been structured in a variety of ways, and these variations could influence the effectiveness ...

    • Five of Five VHHs Neutralizing Poliovirus Bind the Receptor-Binding Site 

      Strauss, Mike; Schotte, Lise; Thys, Bert; Filman, David; Hogle, James (American Society for Microbiology, 2016)
      Nanobodies, or VHHs, that recognize poliovirus type 1 have previously been selected and characterized as candidates for antiviral agents or reagents for standardization of vaccine quality control. In this study, we present ...

    • The five-factor model in schizotypal personality disorder 

      Gurrera, Ronald Joseph; Dickey, Chandlee C.; Niznikiewicz, Margaret A.; Voglmaier, Martina M.; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2005)
      Studies of the five-factor model of personality in schizotypal personality disorder (SPD) have produced inconsistent results, particularly with respect to openness. In the present study, the NEO-FFI was used to measure ...

    • Fixing DNA breaks during class switch recombination 

      Jolly, Christopher J.; Cook, Adam J. L.; Manis, John P. (Rockefeller University Press, 2008)
      Immunoglobulin (Ig) class switch recombination (CSR) involves the breakage and subsequent repair of two DNA sequences, known as switch (S) regions, which flank IgH constant region exons. The resolution of CSR-associated ...

    • FLAG Assay as a Novel Method for Real-Time Signal Generation During PCR: Application to Detection and Genotyping of KRAS Codon 12 Mutations 

      Amicarelli, Giulia; Shehi, Erlet; Makrigiorgos, Gerassimos M.; Adlerstein, Daniel (Oxford University Press, 2007)
      Real-time signal generation methods for detection and characterization of low-abundance mutations in genomic DNA are powerful tools for cancer diagnosis and prognosis. Mutations in codon 12 of the oncogene KRAS, for example, ...

    • Flagellar Motility Is Critical for Listeria monocytogenes Biofilm Formation 

      Lemon, Katherine P.; Higgins, Darren E.; Kolter, Roberto (American Society for Microbiology, 2007)
      The food-borne pathogen Listeria monocytogenes attaches to environmental surfaces and forms biofilms that can be a source of food contamination, yet little is known about the molecular mechanisms of its biofilm development. ...

    • Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity 

      Ren, Tao; Zamboni, Dario S.; Roy, Craig R.; Dietrich, William F.; Vance, Russell E. (Public Library of Science, 2006)
      Macrophages from C57BL/6J (B6) mice restrict growth of the intracellular bacterial pathogen Legionella pneumophila. Restriction of bacterial growth requires caspase-1 and the leucine-rich repeat-containing protein Naip5 ...

    • Flap Endonuclease Activity of Gene 6 Exonuclease of Bacteriophage T7 

      Mitsunobu, Hitoshi; Zhu, Bin; Lee, Seung-Joo; Tabor, Stanley; Richardson, Charles C. (American Society for Biochemistry and Molecular Biology, 2014)
      Background: Flap endonucleases remove 5-single-stranded DNA termini. Results: T7 gene 6 exonuclease is a flap endonuclease that cleaves 5-single-stranded termini one nucleotide into the duplex. Conclusion: The flap ...

    • Flap endonuclease of bacteriophage T7: Possible roles in RNA primer removal, recombination and host DNA breakdown 

      Mitsunobu, Hitoshi; Zhu, Bin; Lee, Seung-Joo; Tabor, Stanley; Richardson, Charles C (Landes Bioscience, 2014)
      Gene 6 protein of bacteriophage T7 has 5′-3′-exonuclease activity specific for duplex DNA. We have found that gene 6 protein also has flap endonuclease activity. The flap endonuclease activity is considerably weaker than ...

    • Flare frequency, healthcare resource utilisation and costs among patients with gout in a managed care setting: a retrospective medical claims-based analysis 

      Jackson, Robert; Shiozawa, Aki; Buysman, Erin K; Altan, Aylin; Korrer, Stephanie; Choi, Hyon (BMJ Publishing Group, 2015)
      Objectives: For most gout patients, excruciatingly painful gout attacks are the major clinical burden of the disease. The goal of this study was to assess the association of frequent gout flares with healthcare burden, and ...

    • Flash Memory: Photochemical Imprinting of Neuronal Action Potentials onto a Microbial Rhodopsin 

      Venkatachalam, Veena; Brinks, Daan; Maclaurin, Dougal; Hochbaum, Daniel; Kralj, Joel; Cohen, Adam E. (American Chemical Society, 2014)
      We developed a technique, “flash memory”, to record a photochemical imprint of the activity state—firing or not firing—of a neuron at a user-selected moment in time. The key element is an engineered microbial rhodopsin ...

    • Flavanols, Mild Cognitive Impairment, and Alzheimer’s Dementia 

      Patel, Ami; Rogers, Jack; Huang, Xudong (2008-04-15)
      Alzheimer’s disease (AD) is a dementing neurological disorder that results in progressive memory loss and cognitive decline thought to be associated with buildup of amyloid plaques and neurofibrillary tangles in the brain. ...

    • Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis 

      Miao, Ji; Ling, Alisha V.; Manthena, Praveen V.; Gearing, Mary E.; Graham, Mark J.; Crooke, Rosanne M.; Croce, Kevin J.; Esquejo, Ryan M.; Clish, Clary B.; Torrecilla, Esther; Vázquez, Gumersindo Fernández; Rubio, Miguel A.; Cabrerizo, Lucio; Barabash, Ana; Pernaute, Andrés Sánchez; Torres, Antonio J.; Vicent, David; Biddinger, Sudha B. (Nature Pub. Group, 2015)
      Despite the well-documented association between insulin resistance and cardiovascular disease, the key targets of insulin relevant to the development of cardiovascular disease are not known. Here, using non-biased profiling ...