Browsing HMS Scholarly Articles by Title
Now showing items 737-756 of 17922
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An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants
(National Academy of Sciences, 2006)Random transposon insertion libraries have proven invaluable in studying bacterial genomes. Libraries that approach saturation must be large, with multiple insertions per gene, making comprehensive genome-wide scanning ... -
An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates
(American Society for Biochemistry and Molecular Biology, 2015)Lin28 is an evolutionarily conserved RNA-binding protein that inhibits processing of pre-let-7 microRNAs (miRNAs) and regulates translation of mRNAs that control developmental timing, pluripotency, metabolism, and ... -
An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene
(National Academy of Sciences, 2005)We have investigated a herpes simplex virus mutant that expresses low levels of thymidine kinase (TK), a phenotype associated with drug resistance and pathogenicity, despite a single-base deletion in the gene. Using a ... -
Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis
(BMJ Publishing Group Ltd., 2013)Objectives: To summarise evidence on the associations of maternal anaemia and prenatal iron use with maternal haematological and adverse pregnancy outcomes; and to evaluate potential exposure-response relations of dose of ... -
Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype
(Nature Publishing Group, 2015)Agonists at the benzodiazepine-binding site of GABAA receptors (BDZs) enhance synaptic inhibition through four subtypes (α1, α2, α3 and α5) of GABAA receptors (GABAAR). When applied to the spinal cord, they alleviate ... -
Analyses of Human–Chimpanzee Orthologous Gene Pairs to Explore Evolutionary Hypotheses of Aging
(Elsevier BV, 2007-05)Compared to chimpanzees (Pan troglodytes), the onset of aging appears to be delayed in the human species. Herein, we studied human-chimpanzee orthologous gene pairs to investigate the selective forces acting on genes ... -
Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors
(Nature Pub. Group, 2015)Decoding heterogeneity of pluripotent stem cell (PSC)-derived neural progeny is fundamental for revealing the origin of diverse progenitors, for defining their lineages, and for identifying fate determinants driving ... -
Analysis and Application of European Genetic Substructure Using 300 K SNP Information
(Public Library of Science, 2008)European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses (PCA) showed the largest ... -
An Analysis and Validation Pipeline for Large-Scale RNAi-Based Screens
(Springer Science and Business Media LLC, 2013-01-16)Large-scale RNAi-based screens are a major technology, but require adequate prioritization and validation of candidate genes from the primary screen. In this work, we performed a large-scale pooled shRNA screen in mouse ... -
Analysis Method and Experimental Conditions Affect Computed Circadian Phase from Melatonin Data
(Public Library of Science, 2012)Accurate determination of circadian phase is necessary for research and clinical purposes because of the influence of the master circadian pacemaker on multiple physiologic functions. Melatonin is presently the most accurate ... -
Analysis of 6,515 exomes reveals a recent origin of most human protein-coding variants
(2012)Establishing the age of each mutation segregating in contemporary human populations is important to fully understand our evolutionary history1,2 and will help facilitate the development of new approaches for disease gene ... -
Analysis of a Mouse Skin Model of Tuberous Sclerosis Complex
(Public Library of Science, 2016)Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor suppressor gene syndrome in which patients develop several types of tumors, including facial angiofibroma, subungual fibroma, Shagreen patch, angiomyolipomas, ... -
Analysis of AKT and ERK1/2 protein kinases in extracellular vesicles isolated from blood of patients with cancer
(Co-Action Publishing, 2014)Background: Extracellular vesicles (EVs) are small nanometre-sized vesicles that are circulating in blood. They are released by multiple cells, including tumour cells. We hypothesized that circulating EVs contain protein ... -
Analysis of Apoptosis Methods Recently Used in Cancer Research and Cell Death & Disease Publications
(Nature Publishing Group, 2012) -
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
(Nature Publishing Group, 2016)Somatic mutations have long been implicated in aging and disease, but their impact on fitness and function is difficult to assess. Here by analysing human cancer genomes we identify mutational patterns associated with ... -
Analysis of Chimpanzee History Based on Genome Sequence Alignments
(Public Library of Science, 2008)Population geneticists often study small numbers of carefully chosen loci, but it has become possible to obtain orders of magnitude for more data from overlaps of genome sequences. Here, we generate tens of millions of ... -
Analysis of Criteria for MRI Diagnosis of TMJ Disc Displacement and Arthralgia
(Hindawi Publishing Corporation, 2012)Aims. To improve diagnostic criteria for TMJ disc displacement (DD). Methods:. The standard protocol for MRI diagnosis of DD, using a 12 o'clock reference position, was compared to an alternative protocol. The alternative ... -
Analysis of Embryoid Bodies Derived from Human Induced Pluripotent Stem Cells as a Means to Assess Pluripotency
(Hindawi Publishing Corporation, 2012)Human induced pluripotent stem cells (hiPSCs) have core properties of unlimited self-renewal and differentiation potential and have emerged as exciting cell sources for applications in regenerative medicine, drug discovery, ... -
Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia
(Nature Publishing Group, 2015)Genetic associations involving both rare and common alleles have been reported for schizophrenia but there have been no systematic scans for rare recessive genotypes using fully phased trio data. Here, we use exome sequencing ...