Browsing HMS Scholarly Articles by Title

Now showing items 7427-7446 of 17922

    • Height, Socioeconomic and Subjective Well-Being Factors among U.S. Women, Ages 49–79 

      Wyshak, Grace (Public Library of Science, 2014)
      Background: A vast literature has associated height with numerous factors, including biological, psychological, socioeconomic, anthropologic, genetic, environmental, and ecologic, among others. The aim of this study is to ...

    • Helicase-DNA polymerase interaction is critical to initiate leading-strand DNA synthesis 

      Zhang, Huidong; Lee, Seung-Joo; Zhu, Bin; Tran, Ngoc Q.; Tabor, Stanley; Richardson, Charles C. (National Academy of Sciences, 2011)
      Interactions between gene 4 helicase and gene 5 DNA polymerase (gp5) are crucial for leading-strand DNA synthesis mediated by the replisome of bacteriophage T7. Interactions between the two proteins that assure high ...

    • Helicobacter pylori Accumulates Photoactive Porphyrins and Is Killed by Visible Light 

      Viveiros, J.; Ahmadi, A.; Ganz, R. A.; Tolkoff, M. J.; Hamblin, Michael; Yang, Changming (American Society for Microbiology, 2005-06-24)
      Helicobacter pylori colonizes the mucus layer of the human stomach and duodenum, causes chronic gastritis, gastric ulcer, and is a risk factor for gastric adenocarcinoma. There is a 20% failure rate in antibiotic therapy, ...

    • Helicobacter pylori cag Pathogenicity Island's Role in B7-H1 Induction and Immune Evasion 

      Lina, Taslima T.; Alzahrani, Shatha; House, Jennifer; Yamaoka, Yoshio; Sharpe, Arlene H.; Rampy, Bill A.; Pinchuk, Irina V.; Reyes, Victor E. (Public Library of Science, 2015)
      During Helicobacter pylori (H. pylori) infection CD4+ T cells in the gastric lamina propria are hyporesponsive and polarized by Th1/Th17 cell responses controlled by Treg cells. We have previously shown that H. pylori ...

    • HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease 

      Vunjak-Novakovic, Gordana; Bhatia, Sangeeta; Chen, Christopher; Hirschi, Karen (BioMed Central, 2010)
      Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables ...

    • Help-Seeking for Pre-Ulcer and Ulcer Conditions of Mycobacterium ulcerans Disease (Buruli Ulcer) in Ghana 

      Ackumey, Mercy M.; Gyapong, Margaret; Pappoe, Matilda; Weiss, Mitchell (American Society of Tropical Medicine and Hygiene, 2011-12-01)
      This study examined sociocultural features of help-seeking for Buruli ulcer–affected persons with pre-ulcers and ulcers in a disease-endemic area in Ghana. A sample of 181 respondents were purposively selected. Fisher's ...

    • Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis 

      Weiner, Orion D; Rentel, Maike C; Ott, Alex; Bourne, Henry R; Schliwa, Manfred; Brown, Glenn E.; Jedrychowski, Mark P.; Yaffe, Michael Bruce; Gygi, Steven P.; Cantley, Lewis C.; Kirschner, Marc W. (Public Library of Science, 2006)
      Migrating cells need to make different actin assemblies at the cell's leading and trailing edges and to maintain physical separation of signals for these assemblies. This asymmetric control of activities represents one ...

    • Hematopoietic gene expression profile in zebrafish kidney marrow 

      Song, Huai-Dong; Sun, Xiao-Jian; Deng, Min; Zhang, Guo-Wei; Zhou, Yi; Wu, Xin-Yan; Sheng, Yan; Chen, Yi; Ruan, Zheng; Jiang, Chun-Lei; Fan, Hui-Yong; Zon, Leonard I.; Kanki, John P.; Liu, Ting Xi; Look, A. Thomas; Chen, Zhu (National Academy of Sciences, 2004)
      The zebrafish kidney marrow is considered to be the organ of definitive hematopoiesis, analogous to the mammalian bone marrow. We have sequenced 26,143 ESTs and isolated 304 cDNAs with putative full-length ORF from a ...

    • The hematopoietic master regulator RUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis 

      Lichtinger, Monika; Obier, Nadine; Ingram, Richard; Hannah, Rebecca; Hoogenkamp, Maarten; Vijayabaskar, MS; Wu, Mengchu; Assi, Salam A; Tenen, Daniel Geoffrey; Westhead, David R; Kouskoff, Valerie; Lacaud, Georges; Göttgens, Berthold; Bonifer, Constanze (BioMed Central, 2013)

    • Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection 

      Zekavat, Seyedeh M.; Lin, Shu-Hong; Bick, Alexander G.; Liu, Aoxing; Paruchuri, Kaavya; Wang, Chen; Uddin, Md Mesbah; Ye, Yixuan; Yu, Zhaolong; Liu, Xiaoxi; Kamatani, Yoichiro; Bhattacharya, Romit; Pirruccello, James; Pampana, Akhil; Loh, Po-Ru; Kohli, Puja; McCarroll, Steven; Kiryluk, Krzysztof; Neale, Benjamin; Ionita-Laza, Iuliana; Engels, Eric; Brown, Derek W.; Smoller, Jordan; Green, Robert; Karlson, Elizabeth; Lebo, Matthew; Ellinor, Patrick; Weiss, Scott; Daly, Mark; Terao, Chikashi; Zhao, Hongyu; Ebert, Benjamin; Reilly, Muredach; Ganna, Andrea; Machiela, Mitchell; Genovese, Giulio; Natarajan, Pradeep (Springer Science and Business Media LLC, 2021-06)
      The burden of mosaic chromosomal alterations in blood-derived DNA, a type of clonal hematopoiesis, is associated with an increased risk for diverse types of infections, including sepsis and pneumonia. Age is the dominant ...

    • Hematopoietic stem cell fate is established by the Notch–Runx pathway 

      Burns, Caroline Erter; Traver, David; Mayhall, Elizabeth; Shepard, Jennifer L.; Zon, Leonard I. (Cold Spring Harbor Laboratory Press, 2005)
      identifying the molecular pathways regulating hematopoictic stem cell (HSC) specification, self-renewal, and expansion remains a fundamental goal of both basic and clinical biology. Here, we analyzed the effects of Notch ...

    • The hematopoietic stem cell niche 

      Park, Dongsu; Sykes, David Brian; Scadden, David Thomas (Frontiers in Bioscience, 2012)
      Hematopoietic stem cells (HSCs) possess the ability to self-renew and to differentiate to mature progeny along multiple different hematopoietic lineages. The function of HSCs depends upon the signals from surrounding cells ...

    • Hematopoietic Stem Cells, Hematopoiesis and Disease: Lessons from the Zebrafish Model 

      Martin, Corey S; Moriyama, Akemi; Zon, Leonard Ira (BioMed Central, 2011)
      The zebrafish model is rapidly gaining prominence in the study of development, hematopoiesis, and disease. The zebrafish provides distinct advantages over other vertebrate models during early embryonic development by ...

    • Hematopoietic Stem-Cell Transplantation in the Resource-Limited Setting: Establishing the First Bone Marrow Transplantation Unit in Bangladesh 

      Yeh, Albert; Khan, Mohiuddin; Harlow, Jason; Biswas, Akhil; Akter, Mafruha; Ferdous, Jannatul; Ara, Tasneem; Islam, Manirul; Caron, Martin; Barron, Anne-Marie; Moran, Jenna; Brezina, Mark; Nazneen, Humayra; Kamruzzaman, Md; Saha, Anup; Marshall, Ariela; Afrose, Salma; Stowell, Christopher; Preffer, Frederic; Bangsberg, David; Goodman, Annekathryn; Attar, Eyal; McAfee, Steven; Spitzer, Thomas; Dey, Bimalangshu (American Society of Clinical Oncology (ASCO), 2018)
      Purpose: Treatment of malignant and nonmalignant hematologic diseases with hematopoietic stem-cell transplantation (HSCT) was first described almost 60 years ago, and its use has expanded significantly over the last 20 ...

    • Heme deficiency of soluble guanylate cyclase induces gastroparesis 

      Cosyns, S. M. R.; Dhaese, I.; Thoonen, Robrecht; Buys, Emmanuel; Vral, A.; Brouckaert, P.; Lefebvre, R. A. (Wiley-Blackwell, 2013)
      Background: Soluble guanylate cyclase (sGC) is the principal target of nitric oxide (NO) to control gastrointestinal motility. The consequence on nitrergic signaling and gut motility of inducing a heme-free status of sGC, ...

    • Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells 

      Wegiel, B; Hedblom, A; Li, M; Gallo, D; Csizmadia, E; Harris, C; Nemeth, Z; Zuckerbraun, B S; Soares, M; Persson, J L; Otterbein, L E (Nature Publishing Group, 2014)
      Critical functions of the immune system are maintained by the ability of myeloid progenitors to differentiate and mature into macrophages. We hypothesized that the cytoprotective gas molecule carbon monoxide (CO), generated ...

    • Heme oxygenase-1 in macrophages controls prostate cancer progression 

      Nemeth, Zsuzsanna; Li, Mailin; Csizmadia, Eva; Döme, Balazs; Johansson, Martin; Persson, Jenny Liao; Seth, Pankaj; Otterbein, Leo; Wegiel, Barbara (Impact Journals LLC, 2015)
      Innate immune cells strongly influence cancer growth and progression via multiple mechanisms including regulation of epithelial to mesenchymal transition (EMT). In this study, we investigated whether expression of the ...

    • Heme oxygenase-1-mediated neuroprotection in subarachnoid hemorrhage via intracerebroventricular deferoxamine 

      LeBlanc, Robert H.; Chen, Ruiya; Selim, Magdy H.; Hanafy, Khalid A. (BioMed Central, 2016)
      Background: Subarachnoid hemorrhage (SAH) is a devastating disease that affects over 30,000 Americans per year. Previous animal studies have explored the therapeutic effects of deferoxamine (DFX) via its iron-chelating ...

    • Hemichordate genomes and deuterostome origins 

      Simakov, Oleg; Kawashima, Takeshi; Marlétaz, Ferdinand; Jenkins, Jerry; Koyanagi, Ryo; Mitros, Therese; Hisata, Kanako; Bredeson, Jessen; Shoguchi, Eiichi; Gyoja, Fuki; Yue, Jia-Xing; Chen, Yi-Chih; Freeman, Robert M.; Sasaki, Akane; Hikosaka-Katayama, Tomoe; Sato, Atsuko; Fujie, Manabu; Baughman, Kenneth W.; Levine, Judith; Gonzalez, Paul; Cameron, Christopher; Fritzenwanker, Jens H.; Pani, Ariel M.; Goto, Hiroki; Kanda, Miyuki; Arakaki, Nana; Yamasaki, Shinichi; Qu, Jiaxin; Cree, Andrew; Ding, Yan; Dinh, Huyen H.; Dugan, Shannon; Holder, Michael; Jhangiani, Shalini N.; Kovar, Christie L.; Lee, Sandra L.; Lewis, Lora R.; Morton, Donna; Nazareth, Lynne V.; Okwuonu, Geoffrey; Santibanez, Jireh; Chen, Rui; Richards, Stephen; Muzny, Donna M.; Gillis, Andrew; Peshkin, Leonid; Wu, Michael; Humphreys, Tom; Su, Yi-Hsien; Putnam, Nicholas H.; Schmutz, Jeremy; Fujiyama, Asao; Yu, Jr-Kai; Tagawa, Kunifumi; Worley, Kim C.; Gibbs, Richard A.; Kirschner, Marc W.; Lowe, Christopher J.; Satoh, Noriyuki; Rokhsar, Daniel S.; Gerhart, John (2015)
      Acorn worms, also known as enteropneust (literally, ‘gut-breathing’) hemichordates, are marine invertebrates that share features with echinoderms and chordates. Together, these three phyla comprise the deuterostomes. Here ...

    • Hemispheric Biases and the Control of Visuospatial Attention: An ERP Study 

      Spencer, Kevin M.; Banich, Marie T (BioMed Central, 2005)
      Background: We examined whether individual differences in hemispheric utilization can interact with the intrinsic attentional biases of the cerebral hemispheres. Evidence suggests that the hemispheres have competing biases ...