Browsing HMS Scholarly Articles by Title

Now showing items 7449-7468 of 17922

    • Hemodynamic Impact of a Spontaneous Cervical Dissection on an Ipsilateral Saccular Aneurysm 

      See, Alfred P.; Gross, Bradley A.; Penn, David L.; Du, Rose; Frerichs, Kai U (Korean Society of Cerebrovascular Surgeons; Society of Korean Endovascular Neurosurgeons, 2016)
      The dynamic, hemodynamic impact of a cervical dissection on an ipsilateral, intracranial saccular aneurysm has not been well illustrated. This 45-year-old female was found to have a small, supraclinoid aneurysm ipsilateral ...

    • Hemoglobin \(A_{1c}\) as a Predictor of Incident Diabetes 

      Cheng, Peiyao; Neugaard, Britta; Foulis, Philip; Conlin, Paul Richard (American Diabetes Association, 2011)
      Objective: Several studies have suggested that \(HbA_{1c}\) levels may predict incident diabetes. With new recommendations for use of \(HbA_{1c}\) in diagnosing diabetes, many patients with \(HbA_{1c}\) results below the ...

    • Hemoglobin A1c and Arterial and Ventricular Stiffness in Older Adults 

      Zieman, Susan J.; Kamineni, Aruna; Ix, Joachim H.; Barzilay, Joshua; Djoussé, Luc; Kizer, Jorge R.; Biggs, Mary L.; de Boer, Ian H.; Chonchol, Michel; Gottdiener, John S.; Selvin, Elizabeth; Newman, Anne B.; Kuller, Lewis H.; Siscovick, David S.; Mukamal, Kenneth J. (Public Library of Science, 2012)
      Objective: Arterial and ventricular stiffening are characteristics of diabetes and aging which confer significant morbidity and mortality; advanced glycation endproducts (AGE) are implicated in this stiffening pathophysiology. ...

    • Hemoglobin A1c Is Associated With Increased Risk of Incident Coronary Heart Disease Among Apparently Healthy, Nondiabetic Men and Women 

      Pai, Jennifer; Cahill, Leah; Hu, Frank B.; Rexrode, Kathryn Marian; Manson, JoAnn Elisabeth; Rimm, Eric B. (Blackwell Publishing Ltd, 2013)
      Background: Hemoglobin A1c (HbA1c), a time‐integrated marker of glycemic control, predicts risk of coronary heart disease (CHD) among diabetics. Few studies have examined HbA1c and risk of CHD among women and men without ...

    • Hemoglobin A1c Levels and Aortic Arterial Stiffness: The Cardiometabolic Risk in Chinese (CRC) Study 

      Liang, Jun; Zhou, Na; Teng, Fei; Zou, Caiyan; Xue, Ying; Yang, Manqing; Song, Huaidong; Qi, Lu (Public Library of Science, 2012)
      Objective: The American Diabetes Association (ADA) recently published new clinical guidelines in which hemoglobin A1c (HbA1c) was recommended as a diagnostic test for diabetes. The present study was to investigate the ...

    • Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis 

      Core, Amanda B.; Canali, Susanna; Babitt, Jodie L. (Frontiers Media S.A., 2014)
      Mutations in hemojuvelin (HJV) are the most common cause of the juvenile-onset form of the iron overload disorder hereditary hemochromatosis. The discovery that HJV functions as a co-receptor for the bone morphogenetic ...

    • Hemopexin in severe inflammation and infection: mouse models and human diseases 

      Lin, Tian; Maita, Dayana; Thundivalappil, Sujatha R; Riley, Frank E; Hambsch, Jasmin; Van Marter, Linda J; Christou, Helen A; Berra, Lorenzo; Fagan, Shawn; Christiani, David C; Warren, H Shaw (BioMed Central, 2015)
      Introduction: Cell-free plasma hemoglobin is associated with poor outcome in patients with sepsis. Extracellular hemoglobin and secondarily released heme amplify inflammation in the presence of microbial TLR ligands and/or ...

    • Hemorrhage from Extra-Antral Gastric Antral Vascular Ectasia in a Patient with Duodenal Heterotopic Gastric Mucosa 

      Gubatan, John; Raines, Nathan; Khosravi, Hasan; Challies, Tracy L.; Berzin, Tyler M. (Hindawi Publishing Corporation, 2016)
      Gastric antral vascular ectasias (GAVE) have been increasingly recognized as an uncommon cause of chronic gastrointestinal bleeding and anemia, although their underlying pathogenesis is not completely well understood. ...

    • Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing β-Methylphenyl-ethylamine (BMPEA): A Case Report 

      Cohen, Pieter; Zeijlon, Rickard; Nardin, Rachel; Keizers, Peter H.J.; Venhuis, Bastiaan (American College of Physicians, 2015-06-16)

    • Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila 

      Nybakken, Kent; Perrimon, Norbert (Elsevier, 2002)

    • Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation 

      Giantsos-Adams, Kristina M.; Koo, Andrew Jia-An; Song, Sukhyun; Sakai, Jiro; Sankaran, Jagadish; Shin, Jennifer H.; Garcia-Cardena, Guillermo; Dewey, C. Forbes (Springer US, 2013)
      The local hemodynamic shear stress waveforms present in an artery dictate the endothelial cell phenotype. The observed decrease of the apical glycocalyx layer on the endothelium in atheroprone regions of the circulation ...

    • Heparan sulphate proteoglycans: the sweet side of development 

      Häcker, Udo; Nybakken, Kent; Perrimon, Norbert (Nature Research (part of Springer Nature), 2005)
      Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. ...

    • Heparin affinity purification of extracellular vesicles 

      Balaj, Leonora; Atai, Nadia A.; Chen, Weilin; Mu, Dakai; Tannous, Bakhos A.; Breakefield, Xandra O.; Skog, Johan; Maguire, Casey A. (Nature Publishing Group, 2015)
      Extracellular vesicles (EVs) are lipid membrane vesicles released by cells. They carry active biomolecules including DNA, RNA, and protein which can be transferred to recipient cells. Isolation and purification of EVs from ...

    • Heparin requirements for full anticoagulation are higher for patients on dabigatran than for those on warfarin – a model-based study 

      Edrich, Thomas; Frendl, Gyorgy; Michaud, Gregory; Paschalidis, Ioannis Ch (Dove Medical Press, 2015)
      Purpose Dabigatran (D) is increasingly used for chronic anticoagulation in place of warfarin (W). These patients may present for catheter-based procedures requiring full anticoagulation with heparin. This study compares ...

    • Heparin-induced cis- and trans-Dimerization Modes of the Thrombospondin-1 N-terminal Domain 

      Tan, Kemin; Duquette, Mark; Liu, Jin-huan; Shanmugasundaram, Kumaran; Joachimiak, Andrzej; Gallagher, John T.; Rigby, Alan C.; Wang, Jia-huai; Lawler, Jack (American Society for Biochemistry and Molecular Biology, 2008)
      Through its interactions with proteins and proteoglycans, thrombospondin-1 (TSP-1) functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular phenotype. We have ...

    • Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury 

      Pyzik, Michal; Rath, Timo; Kuo, Timothy; Win, Sanda; Baker, Kristi; Hubbard, Jonathan; Grenha, Rosa; Gandhi, Amit; Krämer, Thomas D.; Mezo, Adam; Taylor, Zachary; McDonnell, Kevin; Nienaber, Vicki; Andersen, Jan Terje; Mizoguchi, Atsushi; Blumberg, Laurence; Purohit, Shalaka; Jones, Susan; Christianson, Greg; Lencer, Wayne; Sandlie, Inger; Kaplowitz, Neil; Roopenian, Derry; Blumberg, Richard (National Academy of Sciences, 2017)
      The neonatal crystallizable fragment receptor (FcRn) is responsible for maintaining the long half-life and high levels of the two most abundant circulating proteins, albumin and IgG. In the latter case, the protective ...

    • Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability 

      Luther, Jay; Garber, John J.; Khalili, Hamed; Dave, Maneesh; Bale, Shyam Sundhar; Jindal, Rohit; Motola, Daniel L.; Luther, Sanjana; Bohr, Stefan; Jeoung, Soung Won; Deshpande, Vikram; Singh, Gurminder; Turner, Jerrold R.; Yarmush, Martin L.; Chung, Raymond T.; Patel, Suraj J. (2015)
      BACKGROUND & AIMS Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. ...

    • Hepatic Steatosis is Associated with Lower Levels of Physical Activity Measured via Accelerometry 

      Long, Michelle T.; Pedley, Alison; Massaro, Joseph M.; Hoffmann, Udo; Esliger, Dale W.; Vasan, Ramachandran S.; Fox, Caroline S.; Murabito, Joanne M. (2015)
      Objective: Prior studies on the association of physical activity (PA) and non-alcoholic fatty liver disease are limited by reliance on subjective measures of PA. We examined the association between objectively measured PA ...

    • Hepatic tissue engineering: from transplantation to customized cell-based liver directed therapies from the laboratory 

      Fiegel, Henning C; Kaufmann, Peter M; Bruns, Helge; Kluth, Dietrich; Horch, Raymund E; Vacanti, Joseph P; Kneser, Ulrich (Blackwell Publishing Ltd, 2008)
      Abstract Today, liver transplantation is still the only curative treatment for liver failure due to end-stage liver diseases. Donor organ shortage, high cost and the need of immunosuppressive medications are still the major ...

    • Hepatitis B: Prevalence, Hope 

      Hedley-Whyte, John; Milamed, Debra (Ulster Medical Society, 2019-05)