Browsing HMS Scholarly Articles by Title
Now showing items 7544-7563 of 17918
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High Quality Care and Ethical Pay-for-performance: A Society of General Internal Medicine Policy Analysis
(Springer-Verlag, 2009)BACKGROUND: Pay-for-performance is proliferating, yet its impact on key stakeholders remains uncertain. OBJECTIVE: The Society of General Internal Medicine systematically evaluated ethical issues raised by performance-based ... -
High rates of unplanned interruptions from HIV care early after antiretroviral therapy initiation in Nigeria
(BioMed Central, 2015)Background: Unplanned care interruption (UCI) challenges effective HIV treatment. We determined the frequency and risk factors for UCI in Nigeria. Methods: We conducted a retrospective-cohort study of adults initiating ... -
High Resolution Helium Ion Scanning Microscopy of the Rat Kidney
(Public Library of Science, 2013)Helium ion scanning microscopy is a novel imaging technology with the potential to provide sub-nanometer resolution images of uncoated biological tissues. So far, however, it has been used mainly in materials science ... -
High Risk Population Isolate Reveals Low Frequency Variants Predisposing to Intracranial Aneurysms
(Public Library of Science, 2014)3% of the population develops saccular intracranial aneurysms (sIAs), a complex trait, with a sporadic and a familial form. Subarachnoid hemorrhage from sIA (sIA-SAH) is a devastating form of stroke. Certain rare genetic ... -
High Sensitivity 1H-NMR Spectroscopy of Homeopathic Remedies Made in Water
(BioMed Central, 2004)Background: The efficacy of homeopathy is controversial. Homeopathic remedies are made via iterated shaking and dilution, in ethanol or in water, from a starting substance. Remedies of potency 12 C or higher are ultra-dilute ... -
High throughput detection of miRNAs and gene-specific mRNA at the single-cell level by flow cytometry
(2014)Fluorescent in situ hybridization (FISH) is a method that uses fluorescent probes to detect specific nucleic acid sequences at the single cell level. Here we describe optimized protocols that exploit a highly sensitive ... -
High Throughput Kinomic Profiling of Human Clear Cell Renal Cell Carcinoma Identifies Kinase Activity Dependent Molecular Subtypes
(Public Library of Science, 2015)Despite the widespread use of kinase-targeted agents in clear cell renal cell carcinoma (CC-RCC), comprehensive kinase activity evaluation (kinomic profiling) of these tumors is lacking. Thus, kinomic profiling of CC-RCC ... -
High Throughput RNAi Assay Optimization Using Adherent Cell Cytometry
(BioMed Central, 2011)Background: siRNA technology is a promising tool for gene therapy of vascular disease. Due to the multitude of reagents and cell types, RNAi experiment optimization can be time-consuming. In this study adherent cell cytometry ... -
High-Affinity Accumulation of a Maytansinoid in Cells via Weak Tubulin Interaction
(Public Library of Science, 2015)The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules. To identify the ... -
High-Deductible Health Plans Paired With Health Savings Accounts Increased Medication Cost Burden Among Individuals With Bipolar Disorder
(Physicians Postgraduate Press, Inc, 2022-03-09)Objective: High-deductible health plans (HDHPs) paired with health savings accounts (HSAs) require substantial out-of-pocket spending for most services, including medications. We examined effects of HSA-eligible HDHPs on ... -
High-Deductible Insurance and Delay in Care for the Macrovascular Complications of Diabetes
(American College of Physicians, 2018-11-20)Background: Little is known about the long-term effects of high-deductible insurance on care for chronic medical conditions. Objective: To determine whether a transition from low-deductible to high-deductible insurance ... -
A High-Density Admixture Scan in 1,670 African Americans with Hypertension
(Public Library of Science, 2007)Hypertension (HTN) is a devastating disease with a higher incidence in African Americans than European Americans, inspiring searches for genetic variants that contribute to this difference. We report the results of a ... -
A High-Density Genome-Wide Association Screen of Sporadic ALS in US Veterans
(Public Library of Science, 2012)Following reports of an increased incidence of amyotrophic lateral sclerosis (ALS) in U.S. veterans, we have conducted a high-density genome-wide association study (GWAS) of ALS outcome and survival time in a sample of ... -
High-Density Genomewide Linkage Analysis of Exceptional Human Longevity Identifies Multiple Novel Loci
(Public Library of Science, 2010)Background: Human lifespan is approximately 25% heritable, and genetic factors may be particularly important for achieving exceptional longevity. Accordingly, siblings of centenarians have a dramatically higher probability ... -
High-density Lipoprotein Increases the Uptake of Oxidized Low Density Lipoprotein via PPARγ/CD36 Pathway in Inflammatory Adipocytes
(Ivyspring International Publisher, 2015)Aim: Previous studies have demonstrated that the dysregulated-secretion of adipokines by adipocytes may contribute to obesity-associated atherosclerosis (As) and high density lipoprotein (HDL) may protect against atherogenesis ... -
High-Density Lipoprotein-Mediated Cholesterol Efflux Capacity Is Improved by Treatment With Antiretroviral Therapy in Acute Human Immunodeficiency Virus Infection
(Oxford University Press, 2014)Background: Individuals infected with human immunodeficiency virus (HIV) have decreased high-density lipoprotein (HDL)-cholesterol and increased cardiovascular disease (CVD). Reverse cholesterol transport from macrophages ... -
High-Density Reconstitution of Functional Water Channels into Vesicular and Planar Block Copolymer Membranes
(American Chemical Society, 2012)The exquisite selectivity and unique transport properties of membrane proteins can be harnessed for a variety of engineering and biomedical applications if suitable membranes can be produced. Amphiphilic block copolymers ... -
High-Density Single Nucleotide Polymorphism Genome-Wide Linkage Scan for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes
(American Diabetes Association, 2008)Objective: Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) ... -
High-dimensional genomic data bias correction and data integration using MANCIE
(Nature Publishing Group, 2016)High-dimensional genomic data analysis is challenging due to noises and biases in high-throughput experiments. We present a computational method matrix analysis and normalization by concordant information enhancement ...