Now showing items 7544-7563 of 17918

    • High Quality Care and Ethical Pay-for-performance: A Society of General Internal Medicine Policy Analysis 

      Wharam, James Franklin; Paasche-Orlow, Michael K.; Farber, Neil J.; Sinsky, Christine; Rucker, Lisa; Rask, Kimberly J.; Figaro, M. Kathleen; Braddock, Clarence; Barry, Michael John; Sulmasy, Daniel P. (Springer-Verlag, 2009)
      BACKGROUND: Pay-for-performance is proliferating, yet its impact on key stakeholders remains uncertain. OBJECTIVE: The Society of General Internal Medicine systematically evaluated ethical issues raised by performance-based ...
    • High rates of unplanned interruptions from HIV care early after antiretroviral therapy initiation in Nigeria 

      Ahonkhai, Aimalohi A.; Banigbe, Bolanle; Adeola, Juliet; Onwuatuelo, Ifeyinwa; Bassett, Ingrid V.; Losina, Elena; Freedberg, Kenneth A.; Okonkwo, Prosper; Regan, Susan (BioMed Central, 2015)
      Background: Unplanned care interruption (UCI) challenges effective HIV treatment. We determined the frequency and risk factors for UCI in Nigeria. Methods: We conducted a retrospective-cohort study of adults initiating ...
    • High Resolution Helium Ion Scanning Microscopy of the Rat Kidney 

      Rice, William; Van Hoek, Alfred N.; Păunescu, Teodor G.; Huynh, Chuong; Goetze, Bernhard; Singh, Bipin; Scipioni, Larry; Stern, Lewis A.; Brown, Dennis (Public Library of Science, 2013)
      Helium ion scanning microscopy is a novel imaging technology with the potential to provide sub-nanometer resolution images of uncoated biological tissues. So far, however, it has been used mainly in materials science ...
    • High Risk Population Isolate Reveals Low Frequency Variants Predisposing to Intracranial Aneurysms 

      Kurki, Mitja I.; Gaál, Emília Ilona; Kettunen, Johannes; Lappalainen, Tuuli; Menelaou, Androniki; Anttila, Verneri; van 't Hof, Femke N. G.; von und zu Fraunberg, Mikael; Helisalmi, Seppo; Hiltunen, Mikko; Lehto, Hanna; Laakso, Aki; Kivisaari, Riku; Koivisto, Timo; Ronkainen, Antti; Rinne, Jaakko; Kiemeney, Lambertus A. L.; Vermeulen, Sita H.; Kaunisto, Mari A.; Eriksson, Johan G.; Aromaa, Arpo; Perola, Markus; Lehtimäki, Terho; Raitakari, Olli T.; Salomaa, Veikko; Gunel, Murat; Dermitzakis, Emmanouil T.; Ruigrok, Ynte M.; Rinkel, Gabriel J. E.; Niemelä, Mika; Hernesniemi, Juha; Ripatti, Samuli; de Bakker, Paul I. W.; Palotie, Aarno; Jääskeläinen, Juha E. (Public Library of Science, 2014)
      3% of the population develops saccular intracranial aneurysms (sIAs), a complex trait, with a sporadic and a familial form. Subarachnoid hemorrhage from sIA (sIA-SAH) is a devastating form of stroke. Certain rare genetic ...
    • High Sensitivity 1H-NMR Spectroscopy of Homeopathic Remedies Made in Water 

      Anick, David Jay (BioMed Central, 2004)
      Background: The efficacy of homeopathy is controversial. Homeopathic remedies are made via iterated shaking and dilution, in ethanol or in water, from a starting substance. Remedies of potency 12 C or higher are ultra-dilute ...
    • High throughput detection of miRNAs and gene-specific mRNA at the single-cell level by flow cytometry 

      Porichis, Filippos; Hart, Meghan G.; Griesbeck, Morgane; Everett, Holly L.; Hassan, Muska; Baxter, Amy E.; Lindqvist, Madelene; Miller, Sara M.; Soghoian, Damien Z.; Kavanagh, Daniel G.; Reynolds, Susan; Norris, Brett; Mordecai, Scott K.; Nguyen, Quan; Lai, Chunfai; Kaufmann, Daniel E. (2014)
      Fluorescent in situ hybridization (FISH) is a method that uses fluorescent probes to detect specific nucleic acid sequences at the single cell level. Here we describe optimized protocols that exploit a highly sensitive ...
    • High Throughput Kinomic Profiling of Human Clear Cell Renal Cell Carcinoma Identifies Kinase Activity Dependent Molecular Subtypes 

      Anderson, Joshua C.; Willey, Christopher D.; Mehta, Amitkumar; Welaya, Karim; Chen, Dongquan; Duarte, Christine W.; Ghatalia, Pooja; Arafat, Waleed; Madan, Ankit; Sudarshan, Sunil; Naik, Gurudatta; Grizzle, William E.; Choueiri, Toni K.; Sonpavde, Guru (Public Library of Science, 2015)
      Despite the widespread use of kinase-targeted agents in clear cell renal cell carcinoma (CC-RCC), comprehensive kinase activity evaluation (kinomic profiling) of these tumors is lacking. Thus, kinomic profiling of CC-RCC ...
    • High Throughput RNAi Assay Optimization Using Adherent Cell Cytometry 

      Nabzdyk, Christoph G.S.; Chun, Maggie; Pradhan, Leena; Logerfo, Frank W. (BioMed Central, 2011)
      Background: siRNA technology is a promising tool for gene therapy of vascular disease. Due to the multitude of reagents and cell types, RNAi experiment optimization can be time-consuming. In this study adherent cell cytometry ...
    • High-Affinity Accumulation of a Maytansinoid in Cells via Weak Tubulin Interaction 

      Goldmacher, Victor S.; Audette, Charlene A.; Guan, Yinghua; Sidhom, Eriene-Heidi; Shah, Jagesh V.; Whiteman, Kathleen R.; Kovtun, Yelena V. (Public Library of Science, 2015)
      The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules. To identify the ...
    • High-Deductible Health Plans Paired With Health Savings Accounts Increased Medication Cost Burden Among Individuals With Bipolar Disorder 

      Lu, Christine Y.; Zhang, Fang; Wallace, Jamie; LeCates, Robert; Busch, Alisa; Madden, Jeanne; Callahan, Matthew; Foxworth, Phyllis; Soumerai, Stephen; Ross-Degnan, Dennis; Wharam, James (Physicians Postgraduate Press, Inc, 2022-03-09)
      Objective: High-deductible health plans (HDHPs) paired with health savings accounts (HSAs) require substantial out-of-pocket spending for most services, including medications. We examined effects of HSA-eligible HDHPs on ...
    • High-Deductible Insurance and Delay in Care for the Macrovascular Complications of Diabetes 

      Wharam, J. Frank; Lu, Christine Y.; Zhang, Fang; Callahan, Matthew; Xu, Xin; Wallace, Jamie; Soumerai, Stephen; Ross-Degnan, Dennis; Newhouse, Joseph (American College of Physicians, 2018-11-20)
      Background: Little is known about the long-term effects of high-deductible insurance on care for chronic medical conditions. Objective: To determine whether a transition from low-deductible to high-deductible insurance ...
    • A High-Density Admixture Scan in 1,670 African Americans with Hypertension 

      Patterson, Nick; McDonald, Gavin J; Haiman, Christopher A; Ardlie, Kristin; Henderson, Brian E; Henderson, Sean O; Leal, Suzanne M; Deo, Rahul Chandrakant; Tandon, Arti; Reich, David Emil (Public Library of Science, 2007)
      Hypertension (HTN) is a devastating disease with a higher incidence in African Americans than European Americans, inspiring searches for genetic variants that contribute to this difference. We report the results of a ...
    • A High-Density Genome-Wide Association Screen of Sporadic ALS in US Veterans 

      Kwee, Lydia Coulter; Liu, Yutao; Haynes, Carol; Gibson, Jason R.; Stone, Annjanette; Schichman, Steven A.; Kamel, Freya; Nelson, Lorene M.; Topol, Barbara; Van Den Eeden, Stephen K.; Tanner, Caroline M.; Grasso, Daniela L.; Lawson, Robert; Muralidhar, Sumitra; Oddone, Eugene Z.; Schmidt, Silke; Hauser, Michael A.; Cudkowicz, Merit Ester (Public Library of Science, 2012)
      Following reports of an increased incidence of amyotrophic lateral sclerosis (ALS) in U.S. veterans, we have conducted a high-density genome-wide association study (GWAS) of ALS outcome and survival time in a sample of ...
    • High-Density Genomewide Linkage Analysis of Exceptional Human Longevity Identifies Multiple Novel Loci 

      Boyden, Steven Edward; Kunkel, Louis Martens (Public Library of Science, 2010)
      Background: Human lifespan is approximately 25% heritable, and genetic factors may be particularly important for achieving exceptional longevity. Accordingly, siblings of centenarians have a dramatically higher probability ...
    • High-density Lipoprotein Increases the Uptake of Oxidized Low Density Lipoprotein via PPARγ/CD36 Pathway in Inflammatory Adipocytes 

      Zhong, Qiaoqing; Zhao, Shuiping; Yu, Bilian; Wang, Xing; Matyal, Robina; Li, Yunping; Jiang, Zhisheng (Ivyspring International Publisher, 2015)
      Aim: Previous studies have demonstrated that the dysregulated-secretion of adipokines by adipocytes may contribute to obesity-associated atherosclerosis (As) and high density lipoprotein (HDL) may protect against atherogenesis ...
    • High-Density Lipoprotein-Mediated Cholesterol Efflux Capacity Is Improved by Treatment With Antiretroviral Therapy in Acute Human Immunodeficiency Virus Infection 

      Lo, Janet; Rosenberg, Eric S.; Fitzgerald, Michael L.; Bazner, Suzane B.; Ihenachor, Ezinne J.; Hawxhurst, Victoria; Borkowska, Alison H.; Wei, Jeffrey; Zimmerman, Chloe O.; Burdo, Tricia H.; Williams, Kenneth C.; Freeman, Mason W.; Grinspoon, Steven K. (Oxford University Press, 2014)
      Background: Individuals infected with human immunodeficiency virus (HIV) have decreased high-density lipoprotein (HDL)-cholesterol and increased cardiovascular disease (CVD). Reverse cholesterol transport from macrophages ...
    • High-Density Reconstitution of Functional Water Channels into Vesicular and Planar Block Copolymer Membranes 

      Kumar, Manish; Habel, Joachim E. O.; Shen, Yue-xiao; Meier, Wolfgang P.; Walz, Thomas (American Chemical Society, 2012)
      The exquisite selectivity and unique transport properties of membrane proteins can be harnessed for a variety of engineering and biomedical applications if suitable membranes can be produced. Amphiphilic block copolymers ...
    • High-Density Single Nucleotide Polymorphism Genome-Wide Linkage Scan for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes 

      Poznik, G. David; Smiles, Adam M.; Dunn, Jonathon; Wanic, Krzysztof; Moczulski, Dariusz; Canani, Luis; Araki, Shinichi; Makita, Yuichiro; Warram, James H.; Rogus, John Joseph; Pezzolesi, Marcus Guy; Walker, William; Krolewski, Andrzej Stefan (American Diabetes Association, 2008)
      Objective: Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) ...
    • High-dimensional genomic data bias correction and data integration using MANCIE 

      Zang, Chongzhi; Wang, Tao; Deng, Ke; Li, Bo; Hu, Sheng'en; Qin, Qian; Xiao, Tengfei; Zhang, Shihua; Meyer, Clifford A.; He, Housheng Hansen; Brown, Myles; Liu, Jun S.; Xie, Yang; Liu, X. Shirley (Nature Publishing Group, 2016)
      High-dimensional genomic data analysis is challenging due to noises and biases in high-throughput experiments. We present a computational method matrix analysis and normalization by concordant information enhancement ...
    • A High-Dimensional Immune Monitoring Model of HIV-1-Specific CD8 T Cell Responses Accurately Identifies Subjects Achieving Spontaneous Viral Control 

      Proudfoot, J; Vine, S; Cesa, K; Piechocka-Trocha, A; Ndhlovu, Zaza Mtine; Chibnik, Lori; McMullen, A; Porichis, Filippos; Alvino, Donna Marie Lucia; De Jager, Philip Lawrence; Walker, Bruce David; Kaufmann, Daniel (BioMed Central, 2012)