Browsing HMS Scholarly Articles by Title

Now showing items 787-806 of 17922

    • Analysis of the African coelacanth genome sheds light on tetrapod evolution 

      Amemiya, Chris T.; Alföldi, Jessica; Lee, Alison P.; Fan, Shaohua; Philippe, Hervé; MacCallum, Iain; Braasch, Ingo; Manousaki, Tereza; Schneider, Igor; Rohner, Nicolas; Organ, Chris; Chalopin, Domitille; Smith, Jeramiah J.; Robinson, Mark; Dorrington, Rosemary A.; Gerdol, Marco; Aken, Bronwen; Biscotti, Maria Assunta; Barucca, Marco; Baurain, Denis; Berlin, Aaron M.; Blatch, Gregory L.; Buonocore, Francesco; Burmester, Thorsten; Campbell, Michael S.; Canapa, Adriana; Cannon, John P.; Christoffels, Alan; De Moro, Gianluca; Edkins, Adrienne L.; Fan, Lin; Fausto, Anna Maria; Feiner, Nathalie; Forconi, Mariko; Gamieldien, Junaid; Gnerre, Sante; Gnirke, Andreas; Goldstone, Jared V.; Haerty, Wilfried; Hahn, Mark E.; Hesse, Uljana; Hoffmann, Steve; Johnson, Jeremy; Karchner, Sibel I.; Kuraku, Shigehiro; Lara, Marcia; Levin, Joshua Z.; Litman, Gary W.; Mauceli, Evan; Miyake, Tsutomu; Mueller, M. Gail; Nelson, David R.; Nitsche, Anne; Olmo, Ettore; Ota, Tatsuya; Pallavicini, Alberto; Panji, Sumir; Picone, Barbara; Ponting, Chris P.; Prohaska, Sonja J.; Przybylski, Dariusz; Saha, Nil Ratan; Ravi, Vydianathan; Ribeiro, Filipe J.; Sauka-Spengler, Tatjana; Scapigliati, Giuseppe; Searle, Stephen M. J.; Sharpe, Ted; Simakov, Oleg; Stadler, Peter F.; Stegeman, John J.; Sumiyama, Kenta; Tabbaa, Diana; Tafer, Hakim; Turner-Maier, Jason; van Heusden, Peter; White, Simon; Williams, Louise; Yandell, Mark; Brinkmann, Henner; Volff, Jean-Nicolas; Tabin, Clifford J.; Shubin, Neil; Schartl, Manfred; Jaffe, David; Postlethwait, John H.; Venkatesh, Byrappa; Di Palma, Federica; Lander, Eric S.; Meyer, Axel; Lindblad-Toh, Kerstin (2013)
      It was a zoological sensation when a living specimen of the coelacanth was first discovered in 1938, as this lineage of lobe-finned fish was thought to have gone extinct 70 million years ago. The modern coelacanth looks ...

    • Analysis of the Association of the Human Cytomegalovirus DNA Polymerase Subunit UL44 with the Viral DNA Replication Factor UL84 

      Strang, Blair L.; Sinigalia, Elisa; Silva, Laurie A.; Coen, Donald M.; Loregian, Arianna (American Society for Microbiology, 2009)
      The central enzyme responsible for human cytomegalovirus (HCMV) DNA synthesis is a virally encoded DNA polymerase that includes a catalytic subunit, UL54, and a homodimeric accessory subunit, UL44, the presumptive HCMV DNA ...

    • Analysis of the Definition and Utility of Personal Health Records Using Q Methodology 

      Kim, Jeongeun; Bates, David W (JMIR Publications Inc., 2011-11-29)
      Background: Personal health records (PHRs) remain a relatively new technology and concept in practice even though they have been discussed in the literature for more than 50 years. There is no consensus on the definition ...

    • Analysis of the dynamic co-expression network of heart regeneration in the zebrafish 

      Rodius, Sophie; Androsova, Ganna; Götz, Lou; Liechti, Robin; Crespo, Isaac; Merz, Susanne; Nazarov, Petr V.; de Klein, Niek; Jeanty, Céline; González-Rosa, Juan M.; Muller, Arnaud; Bernardin, Francois; Niclou, Simone P.; Vallar, Laurent; Mercader, Nadia; Ibberson, Mark; Xenarios, Ioannis; Azuaje, Francisco (Nature Publishing Group, 2016)
      The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart ...

    • Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy 

      Mitsuhashi, Kei; Yamamoto, Itaru; Kurihara, Hiroyoshi; Kanno, Shinichi; Ito, Miki; Igarashi, Hisayoshi; Ishigami, Keisuke; Sukawa, Yasutaka; Tachibana, Mami; Takahashi, Hiroaki; Tokino, Takashi; Maruyama, Reo; Suzuki, Hiromu; Imai, Kohzoh; Shinomura, Yasuhisa; Yamamoto, Hiroyuki; Nosho, Katsuhiko (Impact Journals LLC, 2015)
      Although gastrointestinal carcinoid tumors are relatively rare in the digestive tract, a quarter of them are present in the rectum. In the absence of specific tumor biomarkers, lymphatic or vascular invasion is generally ...

    • An Analysis of the Relationship Between Metabolism, Developmental Schedules, and Longevity Using Phylogenetic Independent Contrasts 

      Costa, Joana; Church, George; de Magalhães, João Pedro (Gerontological Society of America, 2007-02)
      Comparative studies of aging are often difficult to interpret because of the different factors that tend to correlate with longevity. We used the AnAge database to study these factors, particularly metabolism and developmental ...

    • An Analysis of the Role of the Indigenous Microbiota in Cholesterol Gallstone Pathogenesis 

      Fremont-Rahl, Jacqueline J.; Ge, Zhongming; Umana, Carlos; Whary, Mark T.; Taylor, Nancy S.; Muthupalani, Sureshkumar; Carey, Martin C.; Fox, James G.; Maurer, Kirk J. (Public Library of Science, 2013)
      Background and Aims Cholesterol gallstone disease is a complex process involving both genetic and environmental variables. No information exists regarding what role if any the indigenous gastrointestinal microbiota may ...

    • Analysis of the Yeast Arginine Methyltransferase Hmt1p/rmt1p and Its in Vivo Function. Cofactor Binding and Substrate Interactions 

      McBride, Anne E.; Weiss, Valerie H.; Kim, Heidi K.; Hogle, James M.; Silver, Pamela A. (American Society for Biochemistry and Molecular Biology, 2000)
      Many eukaryotic RNA-binding proteins are modified by methylation of arginine residues. The yeast Saccharomyces cerevisiae contains one major arginine methyltransferase, Hmt1p/Rmt1p, which is not essential for normal cell ...

    • Analysis of Thyroid Response Element Activity During Retinal Development 

      Billings, Nathan; Emerson, Mark Monroe; Cepko, Connie (Public Library of Science, 2010)
      Thyroid hormone (TH) signaling components are expressed during retinal development in dynamic spatial and temporal patterns. To probe the competence of retinal cells to mount a transcriptional response to TH, reporters ...

    • Analytical Complexity in Detection of Gene Variant-by-Environment Exposure Interactions in High-Throughput Genomic and Exposomic Research 

      Patel, Chirag J. (Springer International Publishing, 2016)
      It seems intuitive that disease risk is influenced by the interaction between inherited genetic variants and environmental exposure factors; however, we have few documented interactions between variants and exposures. ...

    • Analyzing Adjuvant Radiotherapy Suggests a Non Monotonic Radio-Sensitivity Over Tumor Volumes 

      Yang, Jack Y; Yang, Mary Qu; Deng, Youping; Niemierko, Andrzej (BioMed Central, 2008)
      Background: Adjuvant Radiotherapy (RT) after surgical removal of tumors proved beneficial in long-term tumor control and treatment planning. For many years, it has been well concluded that radio-sensitivities of tumors ...

    • Analyzing historical trends in breast cancer biomarker expression: a feasibility study (1947–2009) 

      Krieger, Nancy; Habel, Laurel A; Waterman, Pamela D; Shabani, Melina; Ellison-Loschmann, Lis; Achacoso, Ninah S; Acton, Luana; Schnitt, Stuart J (2016)
      BACKGROUND/OBJECTIVES Determining long-term trends in tumor biomarker expression is essential for understanding aspects of tumor biology amenable to change. Limiting the availability of such data, currently used assays for ...

    • Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD 

      Chu, Jen-hwa; Hersh, Craig P; Castaldi, Peter J; Cho, Michael H; Raby, Benjamin A; Laird, Nan; Bowler, Russell; Rennard, Stephen; Loscalzo, Joseph; Quackenbush, John; Silverman, Edwin K (BioMed Central, 2014)
      Background: The investigation of complex disease heterogeneity has been challenging. Here, we introduce a network-based approach, using partial correlations, that analyzes the relationships among multiple disease-related ...

    • Anaphylactic shock depends on PI3K and eNOS-derived NO 

      Cauwels, Anje; Janssen, Ben; Buys, Emmanuel; Sips, Patrick; Brouckaert, Peter (American Society for Clinical Investigation, 2006)
      Anaphylactic shock is a sudden, life-threatening allergic reaction associated with severe hypotension. Platelet-activating factor (PAF) is implicated in the cardiovascular dysfunctions occurring in various shock syndromes, ...

    • Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura 

      Granziera, Cristina; DaSilva, Alexandre F. M; Snyder, Josh; Tuch, David S; May, Arne; Hadjikhani, Nouchine (Public Library of Science, 2006)
      Background: Patients suffering from migraine with aura (MWA) and migraine without aura (MWoA) show abnormalities in visual motion perception during and between attacks. Whether this represents the consequences of structural ...

    • Anatomical basis of lingual hydrostatic deformation 

      Gilbert, R. J.; Napadow, Vitaly J.; Gaige, Terry A.; Wedeen, Van Jay (The Company of Biologists, 2007)
      The mammalian tongue is believed to fall into a class of organs known as muscular hydrostats, organs for which muscle contraction both generates and provides the skeletal support for motion. We propose that the myoarchitecture ...

    • Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules 

      Arendt, Lisa M; Keller, Patricia J; Skibinski, Adam; Goncalves, Kevin; Naber, Stephen P; Buchsbaum, Rachel J; Gilmore, Hannah; Come, Steven E; Kuperwasser, Charlotte (BioMed Central, 2014)
      Introduction: Lineage tracing studies in mice have revealed the localization and existence of lineage-restricted mammary epithelial progenitor cells that functionally contribute to expansive growth during puberty and ...

    • Anatomy and function of an excitatory network in the visual cortex 

      Lee, Wei-Chung Allen; Bonin, Vincent; Reed, Michael; Graham, Brett J.; Hood, Greg; Glattfelder, Katie; Reid, R. Clay (2016)
      Circuits in the cerebral cortex consist of thousands of neurons connected by millions of synapses. A precise understanding of these local networks requires relating circuit activity with the underlying network structure. ...

    • Anatomy and neuro-pathophysiology of the cough reflex arc 

      Polverino, Mario; Fasolino, Marco; Andò, Filippo; Alfieri, Antonio; De Blasio, Francesco; Polverino, Francesca (BioMed Central, 2012)
      Coughing is an important defensive reflex that occurs through the stimulation of a complex reflex arc. It accounts for a significant number of consultations both at the level of general practitioner and of respiratory ...

    • Ancestry of the Timorese: age-related macular degeneration associated genotype and allele sharing among human populations from throughout the world 

      Morrison, Margaux A.; Magalhaes, Tiago R.; Ramke, Jacqueline; Smith, Silvia E.; Ennis, Sean; Simpson, Claire L.; Portas, Laura; Murgia, Federico; Ahn, Jeeyun; Dardenne, Caitlin; Mayne, Katie; Robinson, Rosann; Morgan, Denise J.; Brian, Garry; Lee, Lucy; Woo, Se J.; Zacharaki, Fani; Tsironi, Evangelia E.; Miller, Joan W.; Kim, Ivana K.; Park, Kyu H.; Bailey-Wilson, Joan E.; Farrer, Lindsay A.; Stambolian, Dwight; DeAngelis, Margaret M. (Frontiers Media S.A., 2015)
      We observed that the third leading cause of blindness in the world, age-related macular degeneration (AMD), occurs at a very low documented frequency in a population-based cohort from Timor-Leste. Thus, we determined a ...