Browsing HMS Scholarly Articles by Title

Now showing items 8764-8783 of 17922

    • Infections following bispecific antibodies in myeloma: a systematic review and meta-analysis 

      Reynolds, Gemma; Cliff, Edward; Mohyuddin, Ghulam Rehman; Popat, Rakesh; Midha, Shonali; Liet Hing, Melissa Ng; Harrison, Simon J.; Kesselheim, Aaron; Teh, Benjamin W. (American Society of Hematology, 2023-09-29)
      Bispecific antibodies, a novel immunotherapy with promising efficacy against multiple myeloma, form immune synapses between T-cell surface marker CD3 and malignant cell markers, including B-cell maturation antigen (BCMA), ...

    • Infectious Disease in a Warming World: How Weather Influenced West Nile Virus in the United States (2001–2005) 

      Soverow, Jonathan Edward; Wellenius, Gregory A.; Fisman, David N.; Mittleman, Murray A. (National Institute of Environmental Health Sciences, 2009)
      Background: The effects of weather on West Nile virus (WNV) mosquito populations in the United States have been widely reported, but few studies assess their overall impact on transmission to humans. Objectives: We ...

    • Infectious Diseases Physicians’ Perspectives Regarding Injection Drug Use and Related Infections, United States, 2017 

      Rapoport, Alison; Fischer, Leah S; Santibanez, Scott; Beekmann, Susan E; Polgreen, Philip M; Rowley, Christopher (Oxford University Press (OUP), 2018-06-08)
      Background In the context of the opioid epidemic, injection drug use (IDU)–related infections are an escalating health issue for infectious diseases (ID) physicians in the United States. Methods We conducted a mixed ...

    • Infectious Entry Pathway Mediated by the Human Endogenous Retrovirus K Envelope Protein 

      Robinson, Lindsey; Whelan, Sean (American Society for Microbiology, 2016)
      Endogenous retroviruses (ERVs), the majority of which exist as degraded remnants of ancient viruses, comprise approximately 8% of the human genome. The youngest human ERVs (HERVs) belong to the HERV-K(HML-2) subgroup and ...

    • Infectious Lassa Virus, but Not Filoviruses, Is Restricted by BST-2/Tetherin 

      Radoshitzky, Sheli R.; Dong, Lian; Chi, Xiaoli; Clester, Jeremiah C.; Retterer, Cary; Spurgers, Kevin; Kuhn, Jens H.; Sandwick, Sarah; Ruthel, Gordon; Kota, Krishna; Boltz, Dutch; Warren, Travis; Kranzusch, Philip J.; Whelan, Sean J.; Bavari, Sina (American Society for Microbiology, 2010)
      Bone marrow stromal antigen 2 (BST-2/tetherin) is a cellular membrane protein that inhibits the release of HIV-1. We show for the first time, using infectious viruses, that BST-2 also inhibits egress of arenaviruses but ...

    • Infectious myonecrosis virus has a totivirus-like, 120-subunit capsid, but with fiber complexes at the fivefold axes 

      Tang, Jinghua; Ochoa, Wendy F.; Sinkovits, Robert S.; Poulos, Bonnie T.; Ghabrial, Said A.; Lightner, Donald V.; Baker, Timothy S.; Nibert, Max L. (National Academy of Sciences, 2008)
      Infectious myonecrosis virus (IMNV) is an emerging pathogen of peril shrimp in global aquaculture. Tentatively assigned to family Totiviridae, it has a nonsegmented dsRNA genome of 7,560 bp and an isometric capsid of the ...

    • Infective Endocarditis in the U.S., 1998–2009: A Nationwide Study 

      Bor, David Harkavy; Woolhandler, Steffie; Nardin, Rachel Austen; Brusch, John L.; Himmelstein, David Urius (Public Library of Science, 2013)
      Background: Previous studies based on local case series estimated the annual incidence of endocarditis in the U.S. at about 4 per 100,000 population. Small-scale studies elsewhere have reported similar incidence rates. ...

    • Inference of RhoGAP/GTPase Regulation Using Single-Cell Morphological Data From a Combinatorial RNAi Screen 

      Nir, Oaz; Bakal, Chris; Perrimon, Norbert; Berger, Bonnie (Cold Spring Harbor Laboratory, 2010-03)
      Biological networks are highly complex systems, consisting largely of enzymes that act as molecular switches to activate/inhibit downstream targets via post-translational modification. Computational techniques have been ...

    • Inferring Admixture Histories of Human Populations Using Linkage Disequilibrium 

      Loh, Po-Ru; Lipson, Mark; Patterson, Nick; Moorjani, Priya; Pickrell, Joseph; Reich, David Emil; Berger, Bonnie (Genetics Society of America, 2013)
      Long-range migrations and the resulting admixtures between populations have been important forces shaping human genetic diversity. Most existing methods for detecting and reconstructing historical admixture events are based ...

    • Inferring Carbon Sources from Gene Expression Profiles Using Metabolic Flux Models 

      Brandes, Aaron; Lun, Desmond S.; Ip, Kuhn; Zucker, Jeremy Daniel Hofeld; Colijn, Caroline; Weiner, Brian; Galagan, James E. (Public Library of Science, 2012)
      Background: Bacteria have evolved the ability to efficiently and resourcefully adapt to changing environments. A key means by which they optimize their use of available nutrients is through adjustments in gene expression ...

    • Inferring Condition-Specific Transcription Factor Function from DNA Binding and Gene Expression Data 

      McCord, Rachel Patton; Berger, Michael F; Philippakis, Anthony Andrew; Bulyk, Martha Leonia (2007)
      Numerous genomic and proteomic datasets are permitting the elucidation of transcriptional regulatory networks in the yeast Saccharomyces cerevisiae. However, predicting the condition dependence of regulatory network ...

    • Inferring Developmental Stage Composition from Gene Expression in Human Malaria 

      Joice, Regina; Narasimhan, Vagheesh; Montgomery, Jacqui; Sidhu, Amar Bir; Oh, Keunyoung; Meyer, Evan; Pierre-Louis, Willythssa; Seydel, Karl; Milner, Danny; Williamson, Kim; Wiegand, Roger; Ndiaye, Daouda; Daily, Johanna; Wirth, Dyann; Taylor, Terrie; Huttenhower, Curtis; Marti, Matthias (Public Library of Science, 2013)
      In the current era of malaria eradication, reducing transmission is critical. Assessment of transmissibility requires tools that can accurately identify the various developmental stages of the malaria parasite, particularly ...

    • Inferring Dynamic Signatures of Microbes in Complex Host Ecosystems 

      Gerber, Georg Kurt; Onderdonk, Andrew Bruce; Bry, Lynn (Public Library of Science, 2012)
      The human gut microbiota comprise a complex and dynamic ecosystem that profoundly affects host development and physiology. Standard approaches for analyzing time-series data of the microbiota involve computation of measures ...

    • Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays 

      Park, Yuhyun; Hao, Ke; Zhao, Xiaojun; Mellinghoff, Ingo K; Hofer, Matthias D; Descazeaud, Aurelien; Rubin, Mark A; Sellers, William R; Bourne, Philip; Beroukhim, Rameen; Lin, Ming; Garraway, Levi Alexander; Fox, Edward Alvin; Hochberg, Ephraim Paul; Meyerson, Matthew Langer; Wong, Wing H; Li, Cheng (Public Library of Science, 2006)
      Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on genotyping tumor and ...

    • Inferring Pairwise Interactions from Biological Data Using Maximum-Entropy Probability Models 

      Stein, Richard R.; Marks, Debora S.; Sander, Chris (Public Library of Science, 2015)
      Maximum entropy-based inference methods have been successfully used to infer direct interactions from biological datasets such as gene expression data or sequence ensembles. Here, we review undirected pairwise maximum-entropy ...

    • Inferring parental genomic ancestries using pooled semi-Markov processes 

      Zou, James Y.; Halperin, Eran; Burchard, Esteban; Sankararaman, Sriram (Oxford University Press, 2015)
      Motivation: A basic problem of broad public and scientific interest is to use the DNA of an individual to infer the genomic ancestries of the parents. In particular, we are often interested in the fraction of each parent’s ...

    • Inferring regulatory targets of transcription factors from simultaneous single cell measurements of intranuclear proteins and gene expression 

      Chen, Fei

    • Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity 

      Shi, Jie-Yi; Xing, Qingfeng; Duan, Meng; Wang, Zhi-Chao; Yang, Liu-Xiao; Zhao, Ying-Jun; Wang, Xiao-Ying; Liu, Yun; Deng, Minghua; Ding, Zhen-Bin; Ke, Ai-Wu; Zhou, Jian; Fan, Jia; Cao, Ya; Wang, Jiping; Xi, Ruibin; Gao, Qiang (Impact Journals LLC, 2016)
      Multifocal tumors developed either as independent tumors or as intrahepatic metastases, are very common in primary liver cancer. However, their molecular pathogenesis remains elusive. Herein, a patient with synchronous two ...

    • Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases 

      Choi, Alexander J.S.; Ryter, Stefan W. (Korean Society for Molecular and Cellular Biology, 2014)
      Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 ...

    • Inflammation and adipose tissue macrophages in lipodystrophic mice 

      Herrero, Laura; Shapiro, Hagit; Nayer, Ali; Lee, Jongsoon; Shoelson, Steven E. (National Academy of Sciences, 2010)
      Lipodystrophy and obesity are opposites in terms of a deficiency versus excess of adipose tissue mass, yet these conditions are accompanied by similar metabolic consequences, including insulin resistance, dyslipidemia, ...