Browsing HMS Scholarly Articles by Title
Now showing items 8776-8795 of 17922
-
Inferring Dynamic Signatures of Microbes in Complex Host Ecosystems
(Public Library of Science, 2012)The human gut microbiota comprise a complex and dynamic ecosystem that profoundly affects host development and physiology. Standard approaches for analyzing time-series data of the microbiota involve computation of measures ... -
Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays
(Public Library of Science, 2006)Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on genotyping tumor and ... -
Inferring Pairwise Interactions from Biological Data Using Maximum-Entropy Probability Models
(Public Library of Science, 2015)Maximum entropy-based inference methods have been successfully used to infer direct interactions from biological datasets such as gene expression data or sequence ensembles. Here, we review undirected pairwise maximum-entropy ... -
Inferring parental genomic ancestries using pooled semi-Markov processes
(Oxford University Press, 2015)Motivation: A basic problem of broad public and scientific interest is to use the DNA of an individual to infer the genomic ancestries of the parents. In particular, we are often interested in the fraction of each parent’s ... -
Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity
(Impact Journals LLC, 2016)Multifocal tumors developed either as independent tumors or as intrahepatic metastases, are very common in primary liver cancer. However, their molecular pathogenesis remains elusive. Herein, a patient with synchronous two ... -
Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases
(Korean Society for Molecular and Cellular Biology, 2014)Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 ... -
Inflammation and adipose tissue macrophages in lipodystrophic mice
(National Academy of Sciences, 2010)Lipodystrophy and obesity are opposites in terms of a deficiency versus excess of adipose tissue mass, yet these conditions are accompanied by similar metabolic consequences, including insulin resistance, dyslipidemia, ... -
Inflammation and Disintegration of Intestinal Villi in an Experimental Model for \(Vibrio\) \(parahaemolyticus\)-Induced Diarrhea
(Public Library of Science, 2012)\(Vibrio\) \(parahaemolyticus\) is a leading cause of seafood-borne gastroenteritis in many parts of the world, but there is limited knowledge of the pathogenesis of \(V.\) \(parahaemolyticus\)-induced diarrhea. The absence ... -
Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production
(2015)Circulating levels of fibroblast growth factor 23 (FGF23) are elevated in patients with chronic kidney disease (CKD), but the mechanisms are poorly understood. Here we tested whether inflammation and iron deficiency regulate ... -
Inflammation and plaque vulnerability
(Wiley-Blackwell, 2015)Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs at sites of blood flow disturbance. The disease usually remains silent until a breakdown of integrity at the arterial surface triggers ... -
Inflammation and the Nervous System: The Connection in the Cornea in Patients with Infectious Keratitis
(Association for Research in Vision and Ophthalmology (ARVO), 2011)Purpose. To study the density and morphologic characteristics of epithelial dendritic cells, as correlated to subbasal corneal nerve alterations in acute infectious keratitis (IK) by in vivo confocal microscopy ... -
Inflammation and the Nervous System: The Connection in the Cornea in Patients with Infectious Keratitis
(Association for Research in Vision and Ophthalmology (ARVO), 2011)Purpose.: To investigate the ability of bevacizumab to penetrate the cornea after topical application or subconjunctival injection. Methods.: Bevacizumab 1% was topically applied three times a day to the corneas of mice ... -
Inflammation and thrombosis – testing the hypothesis with anti-inflammatory drug trials
(Schattauer GmbH, 2016)The hypothesis of atherosclerosis as an inflammatory process has been a Leitmotiv in cardiology for the past 20 years, and has now led to the launch of clinical trials aimed at testing whether drugs that primarily target ... -
Inflammation as a Predictive Biomarker for Response to Omega-3 Fatty Acids in Major Depressive Disorder: A Proof of Concept Study
(2015)This study explores whether inflammatory biomarkers act as moderators of clinical response to omega-3 (n-3) fatty acids in subjects with Major Depressive Disorder (MDD). 155 subjects with DSM-IV MDD, a baseline 17-item ... -
Inflammation correlates with symptoms in chronic fatigue syndrome
(Proceedings of the National Academy of Sciences, 2017)It is not unusual for patients who say they are sick to have normal results on standard laboratory testing. The physician often concludes that there is no “real” illness and that the patients’ symptoms likely stem from a ... -
Inflammation Determines the Pro-Adhesive Properties of High Extracellular D-Glucose in Human Endothelial Cells In Vitro and Rat Microvessels In Vivo
(Public Library of Science, 2010)Background: Hyperglycemia is acknowledged as an independent risk factor for developing diabetes-associated atherosclerosis. At present, most therapeutic approaches are targeted at a tight glycemic control in diabetic ... -
Inflammation in the Alzheimer's Disease Cascade: Culprit or Innocent Bystander?
(BioMed Central, 2010)The strongest known risk factors for late-onset Alzheimer disease (LOAD) remain a positive family history and the APOE ε4 allele. van Exel and colleagues used these known risk factors to identify high- and low-risk samples ... -
Inflammation Regulates TMPRSS6 Expression via STAT5
(Public Library of Science, 2013)TMPRSS6 is a regulated gene, with a crucial role in the regulation of iron homeostasis by inhibiting hepcidin expression. The main regulator of iron homeostasis, the antimicrobial peptide hepcidin, which also has a role ... -
Inflammation-induced effector CD4+ T cell interstitial migration is alpha-v integrin dependent
(2014)Leukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues appears to be integrin-independent actin-myosin based, during inflammation changes to the extracellular ...