Browsing HMS Scholarly Articles by Title

Now showing items 8787-8806 of 17922

    • Inflammation and the Nervous System: The Connection in the Cornea in Patients with Infectious Keratitis 

      Cruzat, Andrea; Witkin, Deborah; Baniasadi, Neda; Zheng, Lixin; Ciolino, Joseph B; Jurkunas, Ula V.; Chodosh, James; Pavan-Langston, Deborah; Dana, Reza; Hamrah, Pedram (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      Purpose. To study the density and morphologic characteristics of epithelial dendritic cells, as correlated to subbasal corneal nerve alterations in acute infectious keratitis (IK) by in vivo confocal microscopy ...

    • Inflammation and the Nervous System: The Connection in the Cornea in Patients with Infectious Keratitis 

      Cruzat, Andrea; Witkin, Deborah; Baniasadi, Neda; Zheng, Lixin; Ciolino, Joseph B; Jurkunas, Ula V.; Chodosh, James; Pavan-Langston, Deborah; Dana, Reza; Hamrah, Pedram (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      Purpose.: To investigate the ability of bevacizumab to penetrate the cornea after topical application or subconjunctival injection. Methods.: Bevacizumab 1% was topically applied three times a day to the corneas of mice ...

    • Inflammation and thrombosis – testing the hypothesis with anti-inflammatory drug trials 

      De Caterina, Raffaele; D'Ugo, Emilia; Libby, Peter (Schattauer GmbH, 2016)
      The hypothesis of atherosclerosis as an inflammatory process has been a Leitmotiv in cardiology for the past 20 years, and has now led to the launch of clinical trials aimed at testing whether drugs that primarily target ...

    • Inflammation as a Predictive Biomarker for Response to Omega-3 Fatty Acids in Major Depressive Disorder: A Proof of Concept Study 

      Rapaport, Mark Hyman; Nierenberg, Andrew A; Schettler, Pamela J.; Kinkead, Becky; Cardoos, Amber; Walker, Rosemary; Mischoulon, David (2015)
      This study explores whether inflammatory biomarkers act as moderators of clinical response to omega-3 (n-3) fatty acids in subjects with Major Depressive Disorder (MDD). 155 subjects with DSM-IV MDD, a baseline 17-item ...

    • Inflammation correlates with symptoms in chronic fatigue syndrome 

      Komaroff, Anthony L. (Proceedings of the National Academy of Sciences, 2017)
      It is not unusual for patients who say they are sick to have normal results on standard laboratory testing. The physician often concludes that there is no “real” illness and that the patients’ symptoms likely stem from a ...

    • Inflammation Determines the Pro-Adhesive Properties of High Extracellular D-Glucose in Human Endothelial Cells In Vitro and Rat Microvessels In Vivo 

      Azcutia, Verónica; Abu-Taha, May; Romacho, Tania; Vázquez-Bella, Marta; Matesanz, Nuria; Luscinskas, Francis William; Rodríguez-Mañas, Leocadio; Sanz, María Jesús; Sánchez-Ferrer, Carlos F.; Peiró, Concepción (Public Library of Science, 2010)
      Background: Hyperglycemia is acknowledged as an independent risk factor for developing diabetes-associated atherosclerosis. At present, most therapeutic approaches are targeted at a tight glycemic control in diabetic ...

    • Inflammation in the Alzheimer's Disease Cascade: Culprit or Innocent Bystander? 

      Tan, Zaldy Sy; Seshadri, Sudha (BioMed Central, 2010)
      The strongest known risk factors for late-onset Alzheimer disease (LOAD) remain a positive family history and the APOE ε4 allele. van Exel and colleagues used these known risk factors to identify high- and low-risk samples ...

    • Inflammation Regulates TMPRSS6 Expression via STAT5 

      Meynard, Delphine; Sun, Chia Chi; Wu, Qifang; Chen, Wenjie; Chen, Shanzhuo; Nelson, Caroline N.; Waters, Michael J.; Babitt, Jodie L.; Lin, Herbert Y. (Public Library of Science, 2013)
      TMPRSS6 is a regulated gene, with a crucial role in the regulation of iron homeostasis by inhibiting hepcidin expression. The main regulator of iron homeostasis, the antimicrobial peptide hepcidin, which also has a role ...

    • Inflammation-induced effector CD4+ T cell interstitial migration is alpha-v integrin dependent 

      Overstreet, Michael G.; Gaylo, Alison; Angermann, Bastian; Hughson, Angela; Hyun, Young-min; Lambert, Kris; Acharya, Mridu; Billroth-Maclurg, Alison C.; Rosenberg, Alexander F.; Topham, David J.; Yagita, Hideo; Kim, Minsoo; Lacy-Hulbert, Adam; Meier-Schellersheim, Martin; Fowell, Deborah J. (2014)
      Leukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues appears to be integrin-independent actin-myosin based, during inflammation changes to the extracellular ...

    • Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages 

      Maruyama, Kazuichi; Ii, Masaaki; Cursiefen, Claus; Jackson, David G.; Keino, Hiroshi; Tomita, Minoru; Van Rooijen, Nico; Takenaka, Hideya; D'Amore, Patricia Ann; Stein-Streilein, Joan; Losordo, Douglas W.; Streilein, J. Wayne (American Society for Clinical Investigation, 2005)
      In the inflamed cornea, there is a parallel outgrowth of blood and lymphatic vessels into the normally avascular cornea. We tested whether adaptive and/or innate immune cells were actively involved in the genesis of new ...

    • An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease 

      Zhang, Sufeng; Ermann, Joerg; Succi, Marc; Zhou, Allen; Hamilton, Matthew; Cao, Bonnie; Korzenik, Joshua; Glickman, Jonathan; Vemula, Praveen K.; Glimcher, Laurie; Traverso, Giovanni; Langer, Robert; Karp, Jeffrey (American Association for the Advancement of Science (AAAS), 2015-08-12)
      A hydrogel binds to inflamed tissues, delivering therapeutics locally and reducing systemic drug exposure in mouse models of inflammatory bowel disease.

    • Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women 

      McDonald, Chloe R.; Darling, Anne M.; Conroy, Andrea L.; Tran, Vanessa; Cabrera, Ana; Liles, W. Conrad; Wang, Molin; Aboud, Said; Urassa, Willy; Fawzi, Wafaie W.; Kain, Kevin C. (Public Library of Science, 2015)
      Research Question Preterm birth (PTB) is the leading cause of perinatal mortality worldwide, with the greatest burden occurring in resource-constrained settings. Based on the hypothesis that altered placental angiogenesis ...

    • Inflammatory and Repair Serum Biomarker Pattern. Association to Clinical Outcomes in COPD 

      Casanova, Ciro; Müllerova, Hana; de Torres, Juan P; Corado, Henneth; Varo, Nerea; Cordoba, Elizabeth; Zeineldine, Salah; Paz, Hildegarde; Baz, Rebeca; Cortopassi, Felipe; Pinto-Plata, Victor Manuel; Divo, Miguel Jose; Celli, Bartolome R (BioMed Central, 2012)
      Background: The relationship between serum biomarkers and clinical expressions of COPD is limited. We planned to further describe this association using markers of inflammation and injury and repair. Methods: We studied ...

    • Inflammatory Biomarkers, Death, and Recurrent Nonfatal Coronary Events after an Acute Coronary Syndrome in the MIRACL Study 

      Zamani, Payman; Schwartz, Gregory G.; Olsson, Anders G.; Rifai, Nader; Bao, Weihang; Libby, Peter; Ganz, Peter; Kinlay, Scott (Blackwell Publishing, 2013)
      Background: In acute coronary syndromes, C‐reactive protein (CRP) strongly relates to subsequent death, but surprisingly not to recurrent myocardial infarction. Other biomarkers may reflect different processes related to ...

    • Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease) 

      Xie, Zhihui; Chan, Eunice; Yin, Yuzhi; Ghosh, Chandra C.; Wisch, Laura; Nelson, Celeste; Young, Michael; Parikh, Samir M.; Druey, Kirk M. (2014)
      Objectives: The Systemic Capillary Leak Syndrome (SCLS) is a rare and potentially fatal disorder resembling systemic anaphylaxis that is characterized by transient episodes of hypotensive shock and peripheral edema. The ...

    • The Inflammatory Response to Double Stranded DNA in Endothelial Cells Is Mediated by by NF\(\kappa\)B and TNF\(\alpha\) 

      Patel, Suraj J; Jindal, Rohit; King, Kevin Robert; Tilles, Arno W.; Yarmush, Martin Leon (Public Library of Science, 2011)
      Endothelial cells represent an important barrier between the intravascular compartment and extravascular tissues, and therefore serve as key sensors, communicators, and amplifiers of danger signals in innate immunity and ...

    • Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors 

      Canning, Peter; Ruan, Qui; Schwerd, Tobias; Hrdinka, Matous; Maki, Jenny L.; Saleh, Danish; Suebsuwong, Chalada; Ray, Soumya; Brennan, Paul E.; Cuny, Gregory D.; Uhlig, Holm H.; Gyrd-Hansen, Mads; Degterev, Alexei; Bullock, Alex N. (Elsevier, 2015)
      Summary RIPK2 mediates pro-inflammatory signaling from the bacterial sensors NOD1 and NOD2, and is an emerging therapeutic target in autoimmune and inflammatory diseases. We observed that cellular RIPK2 can be potently ...

    • Inflammatory signaling in human Tuberculosis granulomas is spatially organized 

      Marakalala, Mohlopheni J.; Raju, Ravikiran M.; Sharma, Kirti; Zhang, Yanjia J.; Eugenin, Eliseo A.; Prideaux, Brendan; Daudelin, Isaac B.; Chen, Pei-Yu; Booty, Matthew G.; Kim, Jin Hee; Eum, Seok Yong; Via, Laura E.; Behar, Samuel M.; Barry, Clifton E.; Mann, Matthias; Dartois, Véronique; Rubin, Eric J. (2016)
      Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas ...

    • Influence of a novel histone deacetylase inhibitor panobinostat (LBH589) on the growth of ovarian cancer 

      Garrett, Leslie A.; Growdon, Whitfield B.; Rueda, Bo R.; Foster, Rosemary (BioMed Central, 2016)
      Background: Pre-clinical studies have demonstrated that natural and synthetic histone deacetylase (HDAC) inhibitors can impede the in vitro and in vivo growth of cell lines from a variety of gynecologic and other malignancies. ...

    • Influence of Acute High Glucose on Protein Abundance Changes in Murine Glomerular Mesangial Cells 

      Barati, Michelle T.; Gould, James C.; Salyer, Sarah A.; Isaacs, Susan; Wilkey, Daniel W.; Merchant, Michael L. (Hindawi Publishing Corporation, 2016)
      The effects of acute exposure to high glucose levels as experienced by glomerular mesangial cells in postprandial conditions and states such as in prediabetes were investigated using proteomic methods. Two-dimensional gel ...