Browsing HMS Scholarly Articles by Title

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    • Informed Consent and Placebo Effects: A Content Analysis of Information Leaflets to Identify What Clinical Trial Participants Are Told about Placebos 

      Bishop, Felicity L.; Adams, Alison E. M.; Kaptchuk, Ted Jack; Lewith, George T. (Public Library of Science, 2012)
      Background: Placebo groups are used in randomised clinical trials (RCTs) to control for placebo effects, which can be large. Participants in trials can misunderstand written information particularly regarding technical ...

    • Informed consent and research design in critical care medicine 

      Truog, Robert David (BioMed Central, 1999)

    • The Informed Consent Process in Older Patients Who Developed Delirium 

      Auerswald, Katherine B.; Charpentier, Peter A.; Inouye, Sharon (Elsevier BV, 1997)
      PURPOSE: Delirium, defined as an acute, fluctuating disorder of attention and cognition, is a serious and increasingly common problem for hospitalized older persons. Delirium poses unique ethical challenges for the informed ...

    • Infraglenoidal Scapular Notching in Reverse Total Shoulder Replacement: A Prospective Series of 60 Cases and Systematic Review of the Literature 

      Sadoghi, Patrick; Leithner, Andreas; Vavken, Patrick; Holzer, Andreas; Hochreiter, Josef; Weber, Georg F; Pietschmann, Matthias F; Muller, Peter E (BioMed Central, 2011)
      Background: The impact of infraglenoidal scapular notching in reversed total shoulder arthroplasty (RTSA) is still controversially discussed. Our goal was to evaluate its potential influence on subjective shoulder stability ...

    • Infrared Radiative Properties and Thermal Modeling of Ceramic-Embedded Textile Fabrics 

      Anderson, David M.; Fessler, John R.; Pooley, Matthew A.; Seidel, Scott; Beckham, Haskell W.; Brennan, James F.; Hamblin, Michael (The Optical Society, 2017-02-21)
      The infrared optical properties of textiles are of great importance in numerous applications, including infrared therapy and body thermoregulation. Tuning the spectral response of fabrics by the engineering of composite ...

    • Infusion of donor spleen cells and rejection in liver transplant recipients 

      Scornik, Juan C; Lauwers, Gregory Y.; Reed, Alan I; Howard, Richard J; Dickson, Rolland C; Rosen, Charles B (Wiley-Blackwell, 2000)
      Intact or inactivated donor lymphoid cells have been found to downregulate the alloimmune response in a number of experimental models. We conducted a randomized, prospective, double blind, and placebo-controlled trial to ...

    • Ingestion of Mn and Pb by rats during and after pregnancy alters iron metabolism and behavior in offspring 

      Molina, Ramon M.; Phattanarudee, Siripan; Kim, Jonghan; Thompson, Khristy J.; Wessling-Resnick, Marianne; Maher, Timothy Richard; Brain, Joseph David (Elsevier BV, 2011)
      Manganese (Mn) and lead (Pb) exposures during developmental period can impair development by direct neurotoxicity or through interaction with iron metabolism. Therefore, we examined the effects of maternal ingestion of Mn ...

    • Inhaled Carbon Monoxide Provides Cerebral Cytoprotection in Pigs 

      Mahan, Vicki L.; Zurakowski, David; Otterbein, Leo E.; Pigula, Frank Alexander (Public Library of Science, 2012)
      Carbon monoxide (CO) at low concentrations imparts protective effects in numerous preclinical small animal models of brain injury. Evidence of protection in large animal models of cerebral injury, however, has not been ...

    • Inhaled Nitric Oxide Improves Outcomes After Successful Cardiopulmonary Resuscitation in Mice 

      Minamishima, Shizuka; Kida, Kotaro; Tokuda, Kentaro; Wang, Huifang; Sips, Patrick; Kosugi, Shizuko; Mandeville, Joseph B.; Buys, Emmanuel; Brouckaert, Peter; Liu, Philip K.; Liu, Christina; Bloch, Kenneth Daniel; Ichinose, Fumito (Ovid Technologies (Wolters Kluwer Health), 2011)
      Background—Sudden cardiac arrest (CA) is a leading cause of death worldwide. Breathing nitric oxide (NO) reduces ischemia/reperfusion injury in animal models and in patients. The objective of this study was to learn whether ...

    • Inhaled nitric oxide improves transpulmonary blood flow and clinical outcomes after prolonged cardiac arrest: a large animal study 

      Derwall, Matthias; Ebeling, Andreas; Nolte, Kay Wilhelm; Weis, Joachim; Rossaint, Rolf; Ichinose, Fumito; Nix, Christoph; Fries, Michael; Brücken, Anne (BioMed Central, 2015)
      Introduction: The probability to achieve a return of spontaneous circulation (ROSC) after cardiac arrest can be improved by optimizing circulation during cardiopulomonary resuscitation using a percutaneous left ventricular ...

    • Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women 

      Rebbeck, Timothy R.; Friebel, Tara M.; Mitra, Nandita; Wan, Fei; Chen, Stephanie; Andrulis, Irene L.; Apostolou, Paraskevi; Arnold, Norbert; Arun, Banu K.; Barrowdale, Daniel; Benitez, Javier; Berger, Raanan; Berthet, Pascaline; Borg, Ake; Buys, Saundra S.; Caldes, Trinidad; Carter, Jonathan; Chiquette, Jocelyne; Claes, Kathleen B. M.; Couch, Fergus J.; Cybulski, Cezary; Daly, Mary B.; de la Hoya, Miguel; Diez, Orland; Domchek, Susan M.; Nathanson, Katherine L.; Durda, Katarzyna; Ellis, Steve; Evans, D. Gareth; Foretova, Lenka; Friedman, Eitan; Frost, Debra; Ganz, Patricia A.; Garber, Judy; Glendon, Gord; Godwin, Andrew K.; Greene, Mark H.; Gronwald, Jacek; Hahnen, Eric; Hallberg, Emily; Hamann, Ute; Hansen, Thomas V. O.; Imyanitov, Evgeny N.; Isaacs, Claudine; Jakubowska, Anna; Janavicius, Ramunas; Jaworska-Bieniek, Katarzyna; John, Esther M.; Karlan, Beth Y.; Kaufman, Bella; investigators, KConFab; Kwong, Ava; Laitman, Yael; Lasset, Christine; Lazaro, Conxi; Lester, Jenny; Loman, Niklas; Lubinski, Jan; Manoukian, Siranoush; Mitchell, Gillian; Montagna, Marco; Neuhausen, Susan L.; Nevanlinna, Heli; Niederacher, Dieter; Nussbaum, Robert L.; Offit, Kenneth; Olah, Edith; Olopade, Olufunmilayo I.; Park, Sue Kyung; Piedmonte, Marion; Radice, Paolo; Rappaport-Fuerhauser, Christine; Rookus, Matti A.; Seynaeve, Caroline; Simard, Jacques; Singer, Christian F.; Soucy, Penny; Southey, Melissa; Stoppa-Lyonnet, Dominique; Sukiennicki, Grzegorz; Szabo, Csilla I.; Tancredi, Mariella; Teixeira, Manuel R.; Teo, Soo-Hwang; Terry, Mary Beth; Thomassen, Mads; Tihomirova, Laima; Tischkowitz, Marc; Toland, Amanda Ewart; Toloczko-Grabarek, Aleksandra; Tung, Nadine; van Rensburg, Elizabeth J.; Villano, Danylo; Wang-Gohrke, Shan; Wappenschmidt, Barbara; Weitzel, Jeffrey N.; Zidan, Jamal; Zorn, Kristin K.; McGuffog, Lesley; Easton, Douglas; Chenevix-Trench, Georgia; Antoniou, Antonis C.; Ramus, Susan J. (BioMed Central, 2016)
      Background: Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who have inherited deleterious mutations in both BRCA1 and BRCA2 are rare, and the consequences of ...

    • Inherited Causes of Clonal Haematopoiesis in 97,691 Whole Genomes 

      Bick, Alexander; Weinstock, Joshua S.; Nandakumar, Satish K.; Fulco, Charles P.; Bao, Erik; Zekavat, Seyedeh M.; Szeto, Mindy D.; Liao, Xiaotian; Leventhal, Matthew J.; Nasser, Joseph; Chang, Kyle; Laurie, Cecelia; Burugula, Bala Bharathi; Gibson, Christopher J.; Niroula, Abhishek; Lin, Amy; Taub, Margaret A.; Aguet, Francois; Ardlie, Kristin; Mitchell, Braxton D.; Barnes, Kathleen C.; Moscati, Arden; Fornage, Myriam; Redline, Susan; Psaty, Bruce M.; Silverman, Edwin; Weiss, Scott; Palmer, Nicholette D.; Vasan, Ramachandran S.; Burchard, Esteban G.; Kardia, Sharon L. R.; He, Jiang; Kaplan, Robert C.; Smith, Nicholas L.; Arnett, Donna K.; Schwartz, David A.; Correa, Adolfo; de Andrade, Mariza; Guo, Xiuqing; Konkle, Barbara A.; Custer, Brian; Peralta, Juan M.; Gui, Hongsheng; Meyers, Deborah A.; McGarvey, Stephen T.; Chen, Ida Yii-Der; Shoemaker, M. Benjamin; Peyser, Patricia A.; Broome, Jai G.; Gogarten, Stephanie M.; Wang, Fei Fei; Wong, Quenna; Montasser, May E.; Daya, Michelle; Kenny, Eimear E.; North, Kari E.; Launer, Lenore J.; Cade, Brian; Bis, Joshua C.; Cho, Michael; Lasky-Su, Jessica; Bowden, Donald W.; Cupples, L. Adrienne; Mak, Angel C. Y.; Becker, Lewis C.; Smith, Jennifer A.; Kelly, Tanika N.; Aslibekyan, Stella; Heckbert, Susan R.; Tiwari, Hemant K.; Yang, Ivana V.; Heit, John A.; Lubitz, Steven; Johnsen, Jill M.; Curran, Joanne E.; Wenzel, Sally E.; Weeks, Daniel E.; Rao, Dabeeru C.; Darbar, Dawood; Moon, Jee-Young; Tracy, Russell P.; Buth, Erin J.; Rafaels, Nicholas; Loos, Ruth J. F.; Durda, Peter; Liu, Yongmei; Hou, Lifang; Lee, Jiwon; Kachroo, Priyadarshini; Freedman, Barry I.; Levy, Daniel; Bielak, Lawrence F.; Hixson, James E.; Floyd, James S.; Whitsel, Eric A.; Ellinor, Patrick; Irvin, Marguerite R.; Fingerlin, Tasha E.; Raffield, Laura M.; Armasu, Sebastian M.; Wheeler, Marsha M.; Sabino, Ester C.; Blangero, John; Williams, L. Keoki; Levy, Bruce; Sheu, Wayne Huey-Herng; Roden, Dan M.; Boerwinkle, Eric; Manson, JoAnn; Mathias, Rasika A.; Desai, Pinkal; Taylor, Kent D.; Johnson, Andrew D.; Auer, Paul L.; Kooperberg, Charles; Laurie, Cathy C.; Blackwell, Thomas W.; Smith, Albert V.; Zhao, Hongyu; Lange, Ethan; Lange, Leslie; Rich, Stephen S.; Rotter, Jerome I.; Wilson, James G.; Scheet, Paul; Kitzman, Jacob O.; Lander, Eric; Engreitz, Jesse; Ebert, Benjamin; Reiner, Alexander P.; Jaiswal, Siddhartha; Abecasis, Gonçalo; Sankaran, Vijay; Kathiresan, Sekar; Natarajan, Pradeep (Springer Science and Business Media LLC, 2020-10-14)
      Age is the dominant risk factor for most chronic human diseases; yet the mechanisms by which aging confers this risk are largely unknown. Recently, the age-related acquisition of somatic mutations in regenerating hematopoietic ...

    • Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study 

      Cleynen, Isabelle; Boucher, Gabrielle; Jostins, Luke; Schumm, L Philip; Zeissig, Sebastian; Ahmad, Tariq; Andersen, Vibeke; Andrews, Jane M; Annese, Vito; Brand, Stephan; Brant, Steven R; Cho, Judy H; Daly, Mark J; Dubinsky, Marla; Duerr, Richard H; Ferguson, Lynnette R; Franke, Andre; Gearry, Richard B; Goyette, Philippe; Hakonarson, Hakon; Halfvarson, Jonas; Hov, Johannes R; Huang, Hailang; Kennedy, Nicholas A; Kupcinskas, Limas; Lawrance, Ian C; Lee, James C; Satsangi, Jack; Schreiber, Stephan; Théâtre, Emilie; van der Meulen-de Jong, Andrea E; Weersma, Rinse K; Wilson, David C; Parkes, Miles; Vermeire, Severine; Rioux, John D; Mansfield, John; Silverberg, Mark S; Radford-Smith, Graham; McGovern, Dermot P B; Barrett, Jeffrey C; Lees, Charlie W (Elsevier, 2016)
      Summary Background: Crohn's disease and ulcerative colitis are the two major forms of inflammatory bowel disease; treatment strategies have historically been determined by this binary categorisation. Genetic studies have ...

    • Inherited disorders of gamma-aminobutyric acid metabolism and advances inALDH5A1mutation identification 

      Pearl, Phillip Lawrence; Parviz, Mahsa; Vogel, Kara; Schreiber, John; Theodore, William H; Gibson, K Michael (Wiley-Blackwell, 2014)
      Background and Objectives Inherited disorders of GABA metabolism include SSADH and GABA-transaminase deficiencies. The clinical features, pathophysiology, diagnosis, and management of both are discussed, including an ...

    • Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells 

      Sankaran, Vijay (Springer Science and Business Media LLC, 2020-10-14)

    • Inherited Polymorphisms in Hyaluronan Synthase 1 Predict Risk of Systemic B-Cell Malignancies but Not of Breast Cancer 

      Kuppusamy, Hemalatha; Ogmundsdottir, Helga M.; Baigorri, Eva; Warkentin, Amanda; Steingrimsdottir, Hlif; Haraldsdottir, Vilhelmina; Mant, Michael J.; Mackey, John; Johnston, James B.; Adamia, Sophia; Belch, Andrew R.; Pilarski, Linda M. (Public Library of Science, 2014)
      Genetic variations in the hyaluronan synthase 1 gene (HAS1) influence HAS1 aberrant splicing. HAS1 is aberrantly spliced in malignant cells from multiple myeloma (MM) and Waldenstrom macroglobulinemia (WM), but not in their ...

    • Inherited Variation in Vitamin D Genes Is Associated With Predisposition to Autoimmune Disease Type 1 Diabetes 

      Smyth, Deborah J.; Walker, Neil M.; Stevens, Helen; Burren, Oliver S.; Wallace, Chris; Greissl, Christopher; Ramos-Lopez, Elizabeth; Hyppönen, Elina; Dunger, David B.; Spector, Timothy D.; Ouwehand, Willem H.; Badenhoop, Klaus; Cooper, Jason D.; Wang, Thomas Jue-Fuu; Todd, John A. (American Diabetes Association, 2011)
      Objective: Vitamin D deficiency (25-hydroxyvitamin D [25(OH)D] <50 nmol/L) is commonly reported in both children and adults worldwide, and growing evidence indicates that vitamin D deficiency is associated with many ...

    • Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice 

      He, Chengwei; Qu, Xiying; Wan, Jianbo; Rong, Rong; Huang, Lili; Cai, Chun; Zhou, Keyuan; Gu, Yan; Qian, Steven Y.; Kang, Jing Xuan (Public Library of Science, 2012)
      Recent studies have shown that a tumor-supportive microenvironment is characterized by high levels of pro-inflammatory and pro-angiogenic eicosanoids derived from omega-6 (n−6) arachidonic acid (AA). Although the metabolic ...

    • Inhibiting Metastatic Breast Cancer Cell Migration via the Synergy of Targeted, pH-triggered siRNA Delivery and Chemokine Axis Blockade 

      Guo, Peng; You, Jin-Oh; Yang, Jiang; Jia, Di; Moses, Marsha A.; Auguste, Debra T. (American Chemical Society, 2014)
      Because breast cancer patient survival inversely correlates with metastasis, we engineered vehicles to inhibit both the C-X-C chemokine receptor type 4 (CXCR4) and lipocalin-2 (Lcn2) mediated migratory pathways. pH-responsive ...

    • Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells 

      Lub, Susanne; Maes, Anke; Maes, Ken; De Veirman, Kim; De Bruyne, Elke; Menu, Eline; Fostier, Karel; Kassambara, Alboukadel; Moreaux, Jérôme; Hose, Dirk; Leleu, Xavier; King, Randall W.; Vanderkerken, Karin; Van Valckenborgh, Els (Impact Journals LLC, 2016)
      The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase involved in cell cycle. During the metaphase-anaphase transition the APC/C is activated by Cdc20. The aim of this study is to elucidate the importance ...