Now showing items 8911-8930 of 17918

    • Injectable, spontaneously assembling inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy 

      Kim, Jaeyun; Li, Weiwei Aileen; Choi, Youngjin; Lewin, Sarah A.; Verbeke, Catia S.; Dranoff, Glenn; Mooney, David J. (2015)
      Materials implanted in the body to program host immune cells are a promising alternative to transplantation of ex vivo–manipulated cells to direct an immune response, but required a surgical procedure. Here we demonstrate ...
    • Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs 

      Timmons, Joshua J.; Cohessy, Sean; Wong, Eric T. (MyJove Corporation, 2016)
      Approximately 90% of human cancer deaths are linked to metastasis. Despite the prevalence and relative harm of metastasis, therapeutics for treatment or prevention are lacking. We report a method for the establishment of ...
    • iNKT Cell Production of GM-CSF Controls Mycobacterium tuberculosis 

      Rothchild, Alissa C.; Jayaraman, Pushpa; Nunes-Alves, Cláudio; Behar, Samuel M. (Public Library of Science, 2014)
      Invariant natural killer T (iNKT) cells are activated during infection, but how they limit microbial growth is unknown in most cases. We investigated how iNKT cells suppress intracellular Mycobacterium tuberculosis (Mtb) ...
    • Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation 

      Nathe, Katheryn; Mancuso, Christy J.; Parad, Richard Barry; Van Marter, Linda Joanne; Martin, Camilia Rivera; Stoler-Barak, Liat; Philbin, Victoria J.; Phillips, Michele F.; Palmer, Christine D.; Levy, Ofer (Nature Publishing Group, 2012)
      Background:: Tracheal aspirates (TAs) from critically ill neonates accumulate bacterial endotoxin and demonstrate mobilization of endotoxin-binding proteins, but the potential bioactivity of endotoxin in TAs is unknown. ...
    • Innate Immune Adaptor MyD88 Mediates Neutrophil Recruitment and Myocardial Injury after Ischemia-Reperfusion in Mice 

      Feng, Yan; Zhao, Huailong; Xu, Xinhua; Buys, Emmanuel; Raher, Michael J.; Bopassa, Jean C.; Thibault, Helene; Scherrer-Crosbie, Marielle; Schmidt, Ulrich Hans; Chao, Wei (American Physiological Society, 2008)
      MyD88 is an adaptor protein critical for innate immune response against microbial infection and in certain noninfectious tissue injury. The present study examined the role of MyD88 in myocardial inflammation and injury ...
    • Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines 

      Levy, Ofer; Netea, Mihai G. (2014)
      Unique features of immunity early in life include a distinct immune system particularly reliant on innate immunity, with weak T helper (Th)1-polarizing immune responses, and impaired responses to certain vaccines leading ...
    • Innate Immunity and Resistance to Tolerogenesis in Allotransplantation 

      Benichou, Gilles A.; Tonsho, Makoto; Tocco, Georges; Nadazdin, Ognjenka M.; Madsen, Joren Christian (Frontiers Research Foundation, 2012)
      The development of immunosuppressive drugs to control adaptive immune responses has led to the success of transplantation as a therapy for end-stage organ failure. However, these agents are largely ineffective in suppressing ...
    • Innate immunity is a key factor for the resolution of inflammation in asthma 

      Barnig, Cindy; Levy, Bruce D. (2015)
      The resolution of inflammation is an integral and natural part of the physiological response to tissue injury, infection and allergens or other noxious stimuli. Resolution is now recognised as an active process with highly ...
    • Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1 

      Nichols, Brendan; Jog, Prachi; Lee, Jessica; Blackler, Daniel; Wilmot, Michael; D’Agati, Vivette; Markowitz, Glen; Kopp, Jeffrey; Alper, Seth L.; Pollak, Martin R.; Friedman, David J. (2014)
      Apolipoprotein L1 (APOL1) risk variants greatly elevate the risk of kidney disease in African Americans. Here we report a cohort of patients who developed collapsing focal segmental glomerulosclerosis while receiving ...
    • Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating TH1 Adaptive Immunity 

      Hilgendorf, Ingo; Theurl, Igor; Gerhardt, Louisa M. S.; Robbins, Clinton; Weber, Georg; Gonen, Ayelet; Iwamoto, Yoshiko; Degousee, Norbert; Holderried, Tobias; Winter, Carla; Zirlik, Andreas; Lin, Herbert; Sukhova, Galina; Butany, Jagdish; Rubin, Barry; Witztum, Joseph; Libby, Peter; Nahrendorf, Matthias; Weissleder, Ralph; Swirski, Filip (American Heart Association, 2014)
      Background: Atherosclerotic lesions grow via the accumulation of leukocytes and oxidized lipoproteins in the vessel wall. Leukocytes can attenuate or augment atherosclerosis through the release of cytokines, chemokines, ...
    • Innate Response Activator B Cells Protect Against Microbial Sepsis 

      Rauch, Philipp J.; Chudnovskiy, Aleksey; Robbins, Clinton S.; Weber, Georg F.; Etzrodt, Martin; Hilgendorf, Ingo; Tiglao, Elizabeth; Figueiredo, Jose-Luiz; Iwamoto, Yoshiko; Theurl, Igor; Gorbatov, Rostic; Waring, Michael T.; Chicoine, Adam T.; Mouded, Majd; Pittet, Mikael J.; Nahrendorf, Matthias; Weissleder, Ralph; Swirski, Filip K. (American Association for the Advancement of Science, 2012)
      Recognition and clearance of a bacterial infection are fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B ...
    • The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics 

      Lefkimmiatis, Konstantinos; Leronni, Daniela; Hofer, Aldebaran M. (The Rockefeller University Press, 2013)
      Cyclic AMP (cAMP)-dependent phosphorylation has been reported to exert biological effects in both the mitochondrial matrix and outer mitochondrial membrane (OMM). However, the kinetics, targets, and effectors of the cAMP ...
    • Innervation of Cochlear Hair Cells by Human Induced Pluripotent Stem Cell-Derived Neurons In Vitro 

      Gunewardene, Niliksha; Crombie, Duncan; Dottori, Mirella; Nayagam, Bryony A. (Hindawi Publishing Corporation, 2016)
      Induced pluripotent stem cells (iPSCs) may serve as an autologous source of replacement neurons in the injured cochlea, if they can be successfully differentiated and reconnected with residual elements in the damaged ...
    • Innervation of Thermogenic Adipose Tissue via a Calsyntenin 3β–S100b Axis 

      Zeng, Xing; Ye, Mengchen; Resch, Jon; Jedrychowski, Mark; Hu, Bo; Lowell, Bradford; Ginty, David; Spiegelman, Bruce (Springer Science and Business Media LLC, 2019-05)
      The sympathetic nervous system drives brown and beige adipocyte thermogenesis via release of norepinephrine from local axons. However, the molecular basis underlying the higher levels of sympathetic innervation of thermogenic ...
    • Innovations in nutrition education and global health: the Bangalore Boston nutrition collaborative 

      Kuriyan, Rebecca; Griffiths, Jeffrey K; Finkelstein, Julia L; Thomas, Tinku; Raj, Tony; Bosch, Ronald J; Kurpad, Anura V; Duggan, Christopher (BioMed Central, 2014)
      Background: India has a wide range of nutrition and health problems which require professionals with appropriate skills, knowledge and trans-disciplinary collaborative abilities to influence policy making at the national ...
    • Innovative research methods for studying treatments for rare diseases: methodological review 

      Gagne, Joshua J; Thompson, Lauren; O’Keefe, Kelly; Kesselheim, Aaron S (BMJ Publishing Group Ltd., 2014)
      Objective: To examine methods for generating evidence on health outcomes in patients with rare diseases. Design: Methodological review of existing literature. Setting: PubMed, Embase, and Academic Search Premier searched ...
    • An innovative safe anesthesia and analgesia package for emergency pediatric procedures and surgeries when no anesthetist is available 

      Schwartz, Kevin R.; Fredricks, Karla; Al Tawil, Zaid; Kandler, Taylor; Odenyo, Stella A.; Imbamba, Javan; Nelson, Brett D.; Burke, Thomas F. (Springer Berlin Heidelberg, 2016)
      Background: Adequate pain control through sedation and anesthesia for emergency procedures is a crucial aspect of pediatric emergency care. Resources for administering such anesthesia are extremely limited in many low-income ...
    • Inosine Enhances Axon Sprouting and Motor Recovery after Spinal Cord Injury 

      Kim, Daniel; Zai, Laila; Liang, Peng; Schaffling, Colleen; Ahlborn, David; Benowitz, Larry I. (Public Library of Science, 2013)
      Although corticospinal tract axons cannot regenerate long distances after spinal cord injury, they are able to sprout collateral branches rostral to an injury site that can help form compensatory circuits in cases of ...
    • Inosine Improves Neurogenic Detrusor Overactivity following Spinal Cord Injury 

      Chung, Yeun Goo; Seth, Abhishek; Doyle, Claire; Franck, Debra; Kim, Daniel; Cristofaro, Vivian; Benowitz, Larry I.; Tu, Duong D.; Estrada, Carlos R.; Mauney, Joshua R.; Sullivan, Maryrose P.; Adam, Rosalyn M. (Public Library of Science, 2015)
      Neurogenic detrusor overactivity and the associated loss of bladder control are among the most challenging complications of spinal cord injury (SCI). Anticholinergic agents are the mainstay for medical treatment of detrusor ...
    • Inositol Hexakisphosphate Kinase 1 Regulates Neutrophil Function in Innate Immunity by Inhibiting Phosphatidylinositol-(3,4,5)-Trisphosphate Signaling 

      Prasad, Amit; Jia, Yonghui; Chakraborty, Anutosh; Li, Yitang; Jain, Supriya K.; Zhong, Jia; Roy, Saurabh Ghosh; Loison, Fabien; Mondal, Subhanjan; Sakai, Jiro; Blanchard, Catlyn; Snyder, Solomon H.; Luo, Hongbo (Nature Publishing Group, 2011)
      Inositol phosphates are widely produced throughout animal and plant tissues. Diphosphoinositol pentakisphosphate (InsP7) contains an energetic pyrophosphate bond. Here we demonstrate that disruption of inositol hexakisphosphate ...