Browsing HMS Scholarly Articles by Title
Now showing items 8934-8953 of 17922
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Inositol Trisphosphate 3-Kinase B Is Increased in Human Alzheimer Brain and Exacerbates Mouse Alzheimer Pathology
(Oxford University Press (OUP), 2014)ITPKB phosphorylates inositol 1,4,5-trisphosphate into inositol 1,3,4,5-tetrakisphosphate and controls signal transduction in various hematopoietic cells. Surprisingly, it has been reported that the ITPKB messenger RNA ... -
Inotuzumab Ozogamicin Murine Analog–Mediated B-Cell Depletion Reduces Anti-islet Allo- and Autoimmune Responses
(American Diabetes Association, 2012)B cells participate in the priming of the allo- and autoimmune responses, and their depletion can thus be advantageous for islet transplantation. Herein, we provide an extensive study of the effect of B-cell depletion in ... -
Inpatients hypospadias care: Trends and outcomes from the American nationwide inpatient sample
(The Korean Urological Association, 2015)Purpose Hypospadias is the most common congenital penile anomaly. Information about current utilization patterns of inpatient hypospadias repair as well as complication rates remain poorly evaluated. Materials and Methods ... -
Input–Output Behavior of ErbB Signaling Pathways as Revealed by a Mass Action Model Trained against Dynamic Data
(Nature Publishing Group, 2009)The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis. Nonetheless, it remains poorly understood ... -
Insertions, Deletions, and Single-Nucleotide Polymorphisms at Rare Restriction Enzyme Sites Enhance Discriminatory Power of Polymorphic Amplified Typing Sequences, a Novel Strain Typing System for Escherichia coli O157:H7
(American Society for Microbiology, 2004)Polymorphic amplified typing sequences (PATS) for Escherichia coli O157:H7 (O157) was previously based on indels containing Xbal restriction enzyme sites occurring in O-island sequences of the O157 genome. This strain-typing ... -
Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders
(National Academy of Sciences, 2016)Whole-exome sequencing has been incredibly successful in identifying causal genetic variants and has revealed a number of novel genes associated with blood and other diseases. One limitation of this approach is that it ... -
Insight into transcription factor gene duplication from Caenorhabditis elegans Promoterome-driven expression patterns
(BioMed Central, 2007)Background: The C. elegans Promoterome is a powerful resource for revealing the regulatory mechanisms by which transcription is controlled pan-genomically. Transcription factors will form the core of any systems biology ... -
Insights about variation in meiosis from 31,228 human sperm genomes
(Springer Nature, 2019-05-02)Meiosis, while critical for reproduction, is also variable and error-prone: crossover rates vary among gametes, between the sexes, and among humans of the same sex, and chromosome mis-segregation leads to aneuploidy1-8. ... -
Insights into Assessing the Genetics of Endometriosis
(Current Science Inc., 2012)Endometriosis is a complex disease arising from the interplay between multiple genetic and environmental factors. The genetic variants potentially underlying the hereditary component of endometriosis have been widely ... -
Insights into Imaging of Aortitis
(Springer-Verlag, 2012)Background: Aortitis is a subtype of the more general term “vasculitis”, an inflammatory condition of infectious or noninfectious origin involving the vessel wall. The term “vasculitis” refers to a broad spectrum of diseases ... -
Insights into the Evolution of Longevity from the Bowhead Whale Genome
(Cell Press, 2015)Summary The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, ... -
Insights into Vibrio cholerae Intestinal Colonization from Monitoring Fluorescently Labeled Bacteria
(Public Library of Science, 2014)Vibrio cholerae, the agent of cholera, is a motile non-invasive pathogen that colonizes the small intestine (SI). Most of our knowledge of the processes required for V. cholerae intestinal colonization is derived from ... -
Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins
(Frontiers Media S.A., 2012)Some bacterial toxins and viruses have evolved the capacity to bind mammalian glycosphingolipids to gain access to the cell interior, where they can co-opt the endogenous mechanisms of cellular trafficking and protein ... -
InSite: a computational method for identifying protein-protein interaction binding sites on a proteome-wide scale
(BioMed Central, 2007)We propose InSite, a computational method that integrates high-throughput protein and sequence data to infer the specific binding regions of interacting protein pairs. We compared our predictions with binding sites in ... -
Insomnia, Health-Related Quality of Life and Health Outcomes in Children: A Seven Year Longitudinal Cohort
(Nature Publishing Group, 2016)Insomnia is common in children, and is associated with decreased school performance and increased psychopathology. Although adult insomnia is linked to worsened health-related quality of life (HRQOL), there is insufficient ... -
Institution specific risk factors for 30 day readmission at a community hospital: a retrospective observational study
(BioMed Central, 2014)Background: As of October 1, 2012, hospitals in the United States with excess readmissions based on the Centers for Medicare and Medicaid Services (CMS) risk-adjusted ratio began being penalized. Given the impact of high ... -
Instrumental Music Influences Recognition of Emotional Body Language
(Springer US, 2009)In everyday life, emotional events are perceived by multiple sensory systems. Research has shown that recognition of emotions in one modality is biased towards the emotion expressed in a simultaneously presented but task ... -
Insufficiency of Janus Kinase 2-Autonomous Leptin Receptor Signals for Most Physiologic Leptin Actions
(American Diabetes Association, 2010)OBJECTIVE: Leptin acts via its receptor (LepRb) to signal the status of body energy stores. Leptin binding to LepRb initiates signaling by activating the associated Janus kinase 2 (Jak2) tyrosine kinase, which promotes the ... -
Insulator dysfunction and oncogene activation in IDH mutant gliomas
(2015)Gain-of-function IDH mutations are initiating events that define major clinical and prognostic classes of gliomas1,2. Mutant IDH protein produces a novel onco-metabolite, 2-hydroxyglutarate (2-HG), that interferes with ... -
Insulin Action in Brain Regulates Systemic Metabolism and Brain Function
(American Diabetes Association, 2014)Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are distributed throughout the brain. Insulin acts on these receptors to modulate peripheral metabolism, including regulation of ...