Now showing items 9577-9596 of 17918

    • Leg-tracking and automated behavioural classification in Drosophila 

      Kain, Jamey; Stokes, Chris; Gaudry, Quentin; Song, Xiangzhi; Foley, James; Wilson, Rachel; de Bivort, Benjamin (Nature Pub. Group, 2013)
      Much remains unknown about how the nervous system of an animal generates behaviour, and even less is known about the evolution of behaviour. How does evolution alter existing behaviours or invent novel ones? Progress in ...
    • Legionella Pneumophila Infection Presenting as Headache, Confusion and Dysarthria in a Human Immunodeficiency Virus-1 (HIV-1) Positive Patient: Case Report 

      Robbins, Nathaniel M; Kumar, Aditi; Blair, Barbra McDonagh (BioMed Central, 2012)
      Background: Legionella pneumophila is a common cause of community-acquired pneumonia. Central nervous system dysfunction is common, and diagnosis in the absence of pulmonary symptoms can be challenging. Here we describe ...
    • Leisure Time Physical Activity of Moderate to Vigorous Intensity and Mortality: A Large Pooled Cohort Analysis 

      Moore, Steven C.; Patel, Alpa V.; Matthews, Charles E.; Berrington de Gonzalez, Amy; Park, Yikyung; Katki, Hormuzd A.; Linet, Martha S.; Weiderpass, Elisabete; Visvanathan, Kala; Helzlsouer, Kathy J.; Thun, Michael; Gapstur, Susan M.; Hartge, Patricia; Lee, I-Min (Public Library of Science, 2012)
      Background: Leisure time physical activity reduces the risk of premature mortality, but the years of life expectancy gained at different levels remains unclear. Our objective was to determine the years of life gained after ...
    • Lenalidomide for the Treatment of Relapsed and Refractory Multiple Myeloma 

      Görgün, Güllü; Nijhof, Inger S; Raymakers, Reinier A; Lokhorst, Henk M; Groen, Richard W.j.; Jakubikova, Jana; Mitsiades, Constantine S; Hideshima, Teru; Laubach, Jacob; Richardson, Paul Gerard Guy; Anderson, Kenneth Carl; van de Donk, Niels WCJ (Dove Medical Press, 2012)
      Lenalidomide is an amino-substituted derivative of thalidomide with direct antiproliferative and cytotoxic effects on the myeloma tumor cell, as well as antiangiogenic activity and immunomodulatory effects. Together with ...
    • Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3+CD8+ T cells against Various Solid Tumors 

      Bae, Jooeun; Keskin, Derin B; Cowens, Kristen; Lee, Ann-Hwee; Dranoff, Glen; Munshi, Nikhil C; Anderson, Kenneth C (2016)
      Introduction: Effective combination immunotherapeutic strategies may be required to enhance effector cells’ anti-tumor activities and improve clinical outcomes. Methods: XBP1 antigen-specific cytotoxic T lymphocytes ...
    • Length Polymorphisms in Heme Oxygenase-1 and AKI after Cardiac Surgery 

      Leaf, David Evan; Body, Simon Christopher; Muehlschlegel, Jochen Daniel; McMahon, Gearoid; Lichtner, P.; Collard, C. D.; Shernan, S. K.; Fox, A. A.; Waikar, Sushrut Subhash (American Society of Nephrology (ASN), 2016)
      Heme oxygenase-1 (HO-1) catalyzes the degradation of heme, which may be involved in the pathogenesis of AKI. Length polymorphisms in the number of GT dinucleotide repeats in the HO-1 gene (HMOX1) promoter inversely associate ...
    • Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament severing proteins 

      Narayanan, Praveena; Chatterton, Paul; Ikeda, Akihiro; Ikeda, Sakae; Corey, David P.; Ervasti, James M.; Perrin, Benjamin J. (2015)
      Auditory sensory hair cells depend on stereocilia with precisely regulated lengths to detect sound. Since stereocilia are primarily composed of cross-linked, parallel actin filaments, regulated actin dynamics are essential ...
    • The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication 

      Engelman, Alan N.; Cherepanov, Peter (Public Library of Science, 2008)
      Retroviral replication proceeds through a stable proviral DNA intermediate, and numerous host cell factors have been implicated in its formation. In particular, recent results have highlighted an important role for the ...
    • Lentivirus Display: Stable Expression of Human Antibodies on the Surface of Human Cells and Virus Particles 

      Taube, Ran; Zhu, Quan Karen; Xu, Chen; Diaz-Griffero, Felipe; Sui, Jianhua; Kamau, Erick; Dwyer, Markryan; Aird, Daniel; Marasco, Wayne A. (Public Library of Science, 2008)
      Background: Isolation of human antibodies using current display technologies can be limited by constraints on protein expression, folding and post-translational modifications. Here we describe a discovery platform that ...
    • Lentivirus Display: Stable Expression of Human Antibodies on the Surface of Human Cells and Virus Particles 

      Taube, Ran; Zhu, Quan Karen; Xu, Chen; Diaz-Griffero, Felipe; Sui, Jianhua; Kamau, Erick; Dwyer, Markryan; Aird, Daniel; Marasco, Wayne A. (Public Library of Science, 2008)
      Background: Isolation of human antibodies using current display technologies can be limited by constraints on protein expression, folding and post-translational modifications. Here we describe a discovery platform that ...
    • Lentivirus-delivered stable gene silencing by RNAi in primary cells 

      Stewart, Sheila A.; Dykxhoorn, Derek M.; Palliser, Deborah; Mizuno, Hana; Yu, Evan Y.; An, Dong Sung; Sabatini, David M.; Chen, Irvin S. Y.; Hahn, William C.; Sharp, Phillip A.; Weinberg, Robert A.; Novina, Carl D. (Cold Spring Harbor Laboratory Press, 2003)
      Genome-wide genetic approaches have proven useful for examining pathways of biological significance in model organisms such as Saccharomyces cerevisiae, Drosophila melanogastor, and Caenorhabditis elegans, but similar ...
    • Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women 

      Houde, Andrée-Anne; Légaré, Cécilia; Biron, Simon; Lescelleur, Odette; Biertho, Laurent; Marceau, Simon; Tchernof, André; Vohl, Marie-Claude; Hivert, Marie-France; Bouchard, Luigi (BioMed Central, 2015)
      Background: Leptin (LEP) and adiponectin (ADIPOQ) genes encode adipokines that are mainly secreted by adipose tissues, involved in energy balance and suspected to play a role in the pathways linking adiposity to impaired ...
    • Leptin and Amylin Act in an Additive Manner to Activate Overlapping Signaling Pathways in Peripheral Tissues 

      Moon, Hyun-Seuk; Chamberland, John P.; Diakopoulos, Kalliope N.; Fiorenza, Christina G.; Ziemke, Florencia; Schneider, Benjamin Edward; Mantzoros, Christos (American Diabetes Association, 2011)
      OBJECTIVE: Amylin interacts with leptin to alter metabolism. We evaluated, for the first time, amylin- and/or leptin-activated signaling pathways in human peripheral tissues (hPTs). RESEARCH DESIGN AND METHODS: Leptin and ...
    • Leptin and Its Emerging Role in Children and Adolescents 

      Kelesidis, Iosif; Mantzoros, Christos S. (The Japanese Society for Pediatric Endocrinology, 2006)
      Leptin is an adipocyte-secreted hormone which plays a key role in energy homeostasis. Recent “proof of concept” studies involving leptin administration to humans support its critical role in regulating energy homeostasis, ...
    • Leptin as a Modulator of Neuroendocrine Function in Humans 

      Khan, Sami M.; Hamnvik, Ole-Petter Riksfjord; Brinkoetter, Mary; Mantzoros, Christos (Yonsei University College of Medicine, 2012)
      Leptin, a peptide hormone secreted by adipocytes in proportion of the amount of energy stored in fat, plays a central role in regulating human energy homeostasis. In addition, leptin plays a significant permissive role in ...
    • Leptin in Relation to the Lipodystrophy-Associated Metabolic Syndrome 

      Mantzoros, Christos (Korean Diabetes Association, 2012)
      Leptin, an adipocyte-secreted hormone, regulates energy homeostasis as well as reproductive, neuroendocrine, immune and metabolic functions. Subjects with decreased amounts of fat in their adipose tissue, i.e., lipoatrophy, ...
    • Leptin-Signaling Inhibition Results in Efficient Anti-Tumor Activity in Estrogen Receptor Positive or Negative Breast Cancer 

      Rene Gonzalez, Ruben; Watters, Amber; Xu, Yanbo; Singh, Udai P; Mann, David R; Rueda, Bo Ruben; Penichet, Manuel L (BioMed Central, 2009)
      Introduction: We have shown previously that treatment with pegylated leptin peptide receptor antagonist 2 (PEG-LPrA2) reduced the expression of vascular endothelial growth factor (VEGF), vascular endothelial growth factor ...
    • Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study 

      Subbian, Selvakumar; Tsenova, Liana; Kim, Mi-Jeong; Wainwright, Helen C.; Visser, Annalie; Bandyopadhyay, Nirmalya; Bader, Joel S.; Karakousis, Petros C.; Murrmann, Gabriele B.; Bekker, Linda-Gail; Russell, David G.; Kaplan, Gilla (Public Library of Science, 2015)
      The formation and maintenance of granulomas is central to the host response to Mycobacterium tuberculosis (Mtb) infection. It is widely accepted that the lungs of patients with tuberculosis (TB) usually contain multiple ...
    • Lessons from a Danish Study on Neuropsychological Impairment Related to Lead Exposure 

      Grandjean, Philippe; Lyngbye, Troels; Hansen, Ole Norby (JSTOR, 1991)
      Serious problems emerge when evaluating evidence on lead neurotoxicity in children. The extent of these problems and ways to control them were explored in a study of 1291 children from the first class in the schools of ...
    • Lessons from a Rare Familial Dementia: Amyloid and Beyond 

      Cantlon, Adam; Frigerio, Carlo Sala; Walsh, Dominic M. (2015)
      Here we review the similarities between a rare inherited disorder, familial British dementia (FBD), and the most common of all late-life neurological conditions, Alzheimer's diseases (AD). We describe the symptoms, pathology ...