Browsing HMS Scholarly Articles by Title
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Aqueous Dissolution of Alzheimer’s Disease Aβ Amyloid Deposits by Biometal Depletion
(American Society for Biochemistry & Molecular Biology (ASBMB), 1999-08-13)Zn(II) and Cu(II) precipitate Aβ in vitro into insoluble aggregates that are dissolved by metal chelators. We now report evidence that these biometals also mediate the deposition of Aβ amyloid in Alzheimer’s disease, since ... -
AR, the Cell Cycle, and Prostate Cancer
(The Nuclear Receptor Signaling Atlas, 2008)The androgen receptor (AR) is a critical effector of prostate cancer development and progression. The dependence of this tumor type on AR activity is exploited in treatment of disseminated prostate cancers, wherein ablation ... -
Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
(Nature Publishing Group, 2016)The protein alpha-synuclein (αS) self-assembles into toxic beta-sheet aggregates in Parkinson’s disease, while it is proposed that αS forms soluble alpha-helical multimers in healthy neurons. Here, we have made αS multimers ... -
Architecture and Function of Mechanosensitive Membrane Protein Lattices
(Nature Publishing Group, 2016)Experiments have revealed that membrane proteins can form two-dimensional clusters with regular translational and orientational protein arrangements, which may allow cells to modulate protein function. However, the physical ... -
Architecture of Autoinhibited and Active BRAF–MEK1–14-3-3 Complexes
(Springer Science and Business Media LLC, 2019-10-03)RAF family kinases are RAS-activated switches that initiate signaling through the MAP kinase cascade to control cellular proliferation, differentiation and survival1-3. RAF activity is tightly regulated and inappropriate ... -
Architecture of the Mitochondrial Calcium Uniporter
(2016)Mitochondria from multiple, eukaryotic clades uptake and buffer large amounts of calcium (Ca2+) via an inner membrane transporter called the uniporter. Early studies demonstrated that this transport requires a mitochondrial ... -
Arctigenin alleviates ER stress via activating AMPK
(Nature Publishing Group, 2012)Aim: To investigate the protective effects of arctigenin (ATG), a phenylpropanoid dibenzylbutyrolactone lignan from Arctium lappa L (Compositae), against ER stress in vitro and the underlying mechanisms. Methods: A cell-based ... -
Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales
(eLife Sciences Publications, Ltd, 2015)Agouti-related-peptide (AgRP) neurons—interoceptive neurons in the arcuate nucleus of the hypothalamus (ARC)—are both necessary and sufficient for driving feeding behavior. To better understand the functional roles of AgRP ... -
Are All Placebo Effects Equal? Placebo Pills, Sham Acupuncture, Cue Conditioning and Their Association
(Public Library of Science, 2013)Placebo treatments and healing rituals have been used to treat pain throughout history. The present within-subject crossover study examines the variability in individual responses to placebo treatment with verbal suggestion ... -
Are Chinese pediatricians missing the opportunity to help parents quit smoking?
(BioMed Central, 2016)Background: Secondhand smoke (SHS) exposure of children due to parental tobacco use is a particularly prevalent health issue and is associated with adverse health outcomes. Following the US Clinical Practice guidelines, ... -
Are Clinical Genomes Already Becoming Semi-Routine For Patient Care?
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Are Complementary Therapies and Integrative Care Cost-Effective? A Systematic Review of Economic Evaluations
(BMJ Group, 2012)Objective: A comprehensive systematic review of economic evaluations of complementary and integrative medicine (CIM) to establish the value of these therapies to health reform efforts. Data sources PubMed, CINAHL, AMED, ... -
Are Dietary Bioactives Ready for Recommended Intakes?12
(American Society for Nutrition, 2013)Research has shown that numerous dietary bioactive components that are not considered essential may still be beneficial to health. The dietary reference intake (DRI) process has been applied to nonessential nutrients, such ... -
Are family, neighbourhood and school social capital associated with higher self-rated health among Croatian high school students? A population-based study
(BMJ Publishing Group, 2015)Objectives: We investigated the associations between self-rated health and social capital among Croatian high school students. Design: A cross-sectional survey among high school students was carried out in the 2013–2014 ... -
Are Maternal Social Networks and Perceptions of Trust Associated with Suspected Autism Spectrum Disorder in Offspring? A Population-Based Study in Japan
(Public Library of Science, 2014)Objective: To investigate the associations of maternal social networks and perceptions of trust with the prevalence of suspected autism spectrum disorders in 18-month-old offspring in Japan. Methods: Questionnaires included ... -
Are Meaningful Use Stage 2 certified EHRs ready for interoperability? Findings from the SMART C-CDA Collaborative
(BMJ Publishing Group, 2014)Background and objective Upgrades to electronic health record (EHR) systems scheduled to be introduced in the USA in 2014 will advance document interoperability between care providers. Specifically, the second stage of the ... -
Are obesity risk genes associated with binge eating in adolescence?
(John Wiley & Sons, Ltd, 2015)Objective: Cognitions and behaviors characteristic of binge eating are associated with a polymorphism in the FTO gene, robustly related to body mass index (BMI) and obesity risk. We investigated the association between ... -
Are Onconeural Antibodies a Clinical Phenomenology in Paraneoplastic Limbic Encephalitis?
(Hindawi Publishing Corporation, 2013)Paraneoplastic neurological syndromes (PNSs) occur in patients with cancer and can cause clinical symptoms and signs of dysfunction of the nervous system that are not due to a local effect of the tumor or its metastases. ... -
Are patients more likely to have hip osteoarthritis progression and femoral head collapse after hip steroid/anesthetic injections? A retrospective observational study
(Springer Science and Business Media LLC, 2019-03-06) -
Are Preterm Newborns Who Have Relative Hyperthyrotropinemia at Increased Risk of Brain Damage?
(Walter de Gruyter GmbH, 2014-11)Background We sought to disentangle the contributions of hyperthyrotropinemia (an indicator of thyroid dysfunction) (HTT) and intermittent or sustained systemic inflammation (ISSI) to structural and functional indicators ...