Browsing HMS Scholarly Articles by Keyword "Actinobacteria"

Now showing items 1-5 of 5

    • CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease 

      Sakai, Shunsuke; Kauffman, Keith D.; Sallin, Michelle A.; Sharpe, Arlene H.; Young, Howard A.; Ganusov, Vitaly V.; Barber, Daniel L. (Public Library of Science, 2016)
      IFN-γ–producing CD4 T cells are required for protection against Mycobacterium tuberculosis (Mtb) infection, but the extent to which IFN-γ contributes to overall CD4 T cell-mediated protection remains unclear. Furthermore, ...

    • Comprehensive Definition of the SigH Regulon of Mycobacterium tuberculosis Reveals Transcriptional Control of Diverse Stress Responses 

      Sharp, Jared D.; Singh, Atul K.; Park, Sang Tae; Lyubetskaya, Anna; Peterson, Matthew W.; Gomes, Antonio L. C.; Potluri, Lakshmi-Prasad; Raman, Sahadevan; Galagan, James E.; Husson, Robert N. (Public Library of Science, 2016)
      Expression of SigH, one of 12 Mycobacterium tuberculosis alternative sigma factors, is induced by heat, oxidative and nitric oxide stresses. SigH activation has been shown to increase expression of several genes, including ...

    • Nutritional Status and Tuberculosis Risk in Adult and Pediatric Household Contacts 

      Aibana, Omowunmi; Acharya, Xeno; Huang, Chuan-Chin; Becerra, Mercedes C.; Galea, Jerome T.; Chiang, Silvia S.; Contreras, Carmen; Calderon, Roger; Yataco, Rosa; Velásquez, Gustavo E.; Tintaya, Karen; Jimenez, Judith; Lecca, Leonid; Murray, Megan B. (Public Library of Science, 2016)
      Background: Studies show obesity decreases risk of tuberculosis (TB) disease. There is limited evidence on whether high body mass index also protects against TB infection; how very high body mass indices influence TB risk; ...

    • TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection 

      Jayaraman, Pushpa; Jacques, Miye K.; Zhu, Chen; Steblenko, Katherine M.; Stowell, Britni L.; Madi, Asaf; Anderson, Ana C.; Kuchroo, Vijay K.; Behar, Samuel M. (Public Library of Science, 2016)
      While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs ...

    • The Tuberculosis Cascade of Care in India’s Public Sector: A Systematic Review and Meta-analysis 

      Subbaraman, Ramnath; Nathavitharana, Ruvandhi R.; Satyanarayana, Srinath; Pai, Madhukar; Thomas, Beena E.; Chadha, Vineet K.; Rade, Kiran; Swaminathan, Soumya; Mayer, Kenneth H. (Public Library of Science, 2016)
      Background: India has 23% of the global burden of active tuberculosis (TB) patients and 27% of the world’s “missing” patients, which includes those who may not have received effective TB care and could potentially spread ...