Browsing HMS Scholarly Articles by Keyword "Aggregation"

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    • Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease 

      Pooler, Amy M; Polydoro, Manuela; Maury, Eduardo A; Nicholls, Samantha B; Reddy, Snigdha M; Wegmann, Susanne; William, Christopher; Saqran, Lubna; Cagsal-Getkin, Ozge; Pitstick, Rose; Beier, David R; Carlson, George A; Spires-Jones, Tara L; Hyman, Bradley T (BioMed Central, 2015)
      Introduction: In early stages of Alzheimer’s disease (AD), neurofibrillary tangles (NFT) are largely restricted to the entorhinal cortex and medial temporal lobe. At later stages, when clinical symptoms generally occur, ...

    • Exosomal cell-to-cell transmission of alpha synuclein oligomers 

      Danzer, Karin M; Kranich, Lisa R; Ruf, Wolfgang P; Cagsal-Getkin, Ozge; Winslow, Ashley R; Zhu, Liya; Vanderburg, Charles R.; McLean, Pamela J (BioMed Central, 2012)
      Background: Aggregation of alpha-synuclein (αsyn) and resulting cytotoxicity is a hallmark of sporadic and familial Parkinson’s disease (PD) as well as dementia with Lewy bodies, with recent evidence implicating oligomeric ...