Now showing items 1-4 of 4

    • Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via G\(_{i}\) and Akt-Dependent Actin Cytoskeleton Remodeling 

      Siddaramappa Umapathy, Nagavedi; Kaczmarek, Elzbieta; Fatteh, Nooreen; Burns, Nana; Lucas, Rudolf; Stenmark, Kurt R.; Verin, Alexander D.; Gerasimovskaya, Evgenia V. (Public Library of Science, 2013)
      Background: In a neonatal model of hypoxic pulmonary hypertension, a dramatic pulmonary artery adventitial thickening, accumulation of inflammatory cells in the adventitial compartment, and angiogenic expansion of the vasa ...
    • Akt Regulates TNFα Synthesis Downstream of RIP1 Kinase Activation during Necroptosis 

      McNamara, Colleen R.; Ahuja, Ruchita; Osafo-Addo, Awo D.; Barrows, Douglas; Kettenbach, Arminja; Skidan, Igor; Teng, Xin; Cuny, Gregory Douglas; Gerber, Scott; Degterev, Alexei (Public Library of Science, 2013)
      Necroptosis is a regulated form of necrotic cell death that has been implicated in the pathogenesis of various diseases including intestinal inflammation and systemic inflammatory response syndrome (SIRS). In this work, ...
    • Doxycycline Regulated Induction of AKT in Murine Prostate Drives Proliferation Independently of p27 Cyclin Dependent Kinase Inhibitor Downregulation 

      Wang, Hongyun; Xu, Youyuan; Fang, Zi; Chen, Sen; Balk, Steven Paul; Yuan, Xin (Public Library of Science, 2012)
      The PI3 kinase/AKT pathway has been shown to increase degradation of the p27 cyclin dependent kinase inhibitor through phosphorylation of consensus AKT sites on p27 and SKP2, and AKT driven proliferation may be checked by ...
    • Somatic Mutations of PIK3R1 Promote Gliomagenesis 

      Quayle, Steven N.; Cheung, Lydia W T.; Wiedemeyer, Ruprecht; Dewan, Robert W.; Huang-Hobbs, Emmet; Zhuang, Li; Mills, Gordon B.; Chin, Lynda; Lee, Jennifer Y.; Ding, Li; Wilson, Richard K.; Ligon, Keith Lloyd; Cantley, Lewis C. (Public Library of Science, 2012)
      The phosphoinositide 3-kinase (PI3K) pathway is targeted for frequent alteration in glioblastoma (GBM) and is one of the core GBM pathways defined by The Cancer Genome Atlas. Somatic mutations of PIK3R1 are observed in ...