Browsing HMS Scholarly Articles by Keyword "Amyloid plaques"

Now showing items 1-3 of 3

    • 3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish” 

      Choi, Se Hoon; Kim, Young Hye; Quinti, Luisa; Tanzi, Rudolph E.; Kim, Doo Yeon (BioMed Central, 2016)
      Alzheimer’s disease (AD) transgenic mice have been used as a standard AD model for basic mechanistic studies and drug discovery. These mouse models showed symbolic AD pathologies including β-amyloid (Aβ) plaques, gliosis ...

    • Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease 

      Pooler, Amy M; Polydoro, Manuela; Maury, Eduardo A; Nicholls, Samantha B; Reddy, Snigdha M; Wegmann, Susanne; William, Christopher; Saqran, Lubna; Cagsal-Getkin, Ozge; Pitstick, Rose; Beier, David R; Carlson, George A; Spires-Jones, Tara L; Hyman, Bradley T (BioMed Central, 2015)
      Introduction: In early stages of Alzheimer’s disease (AD), neurofibrillary tangles (NFT) are largely restricted to the entorhinal cortex and medial temporal lobe. At later stages, when clinical symptoms generally occur, ...

    • Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer’s disease 

      McCarter, Joanna F.; Liebscher, Sabine; Bachhuber, Teresa; Abou-Ajram, Claudia; Hübener, Mark; Hyman, Bradley T.; Haass, Christian; Meyer-Luehmann, Melanie (Springer Berlin Heidelberg, 2013)
      Amyloid-β (Aβ) plaque deposition plays a central role in the pathogenesis of Alzheimer’s disease (AD). Post-mortem analysis of plaque development in mouse models of AD revealed that plaques are initially small, but then ...