Now showing items 1-20 of 203

    • 3D Multi-isotope Imaging Mass Spectrometry Reveals Penetration of \(^{18}O\)-Trehalose in Mouse Sperm Nucleus 

      Lechene, Claude P.; Lee, Gloria Y.; Poczatek, J. Collin; Toner, Mehmet; Biggers, John Dennis (Public Library of Science, 2012)
      The prevalence of genetically engineered mice in medical research has led to ever increasing storage costs. Trehalose has a significant beneficial effect in preserving the developmental potential of mouse sperm following ...
    • 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice 

      Fu, Hongjun; Hussaini, S. Abid; Wegmann, Susanne; Profaci, Caterina; Daniels, Jacob D.; Herman, Mathieu; Emrani, Sheina; Figueroa, Helen Y.; Hyman, Bradley T.; Davies, Peter; Duff, Karen E. (Public Library of Science, 2016)
      3D volume imaging using iDISCO+ was applied to observe the spatial and temporal progression of tau pathology in deep structures of the brain of a mouse model that recapitulates the earliest stages of Alzheimer’s disease ...
    • Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1 

      Calvo, Jennifer A.; Moroski-Erkul, Catherine A.; Lake, Annabelle; Eichinger, Lindsey W.; Shah, Dharini; Jhun, Iny; Limsirichai, Prajit; Bronson, Roderick Terry; Christiani, David C.; Meira, Lisiane B.; Samson, Leona D. (Public Library of Science, 2013)
      Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential ...
    • Acellular Bi-Layer Silk Fibroin Scaffolds Support Tissue Regeneration in a Rabbit Model of Onlay Urethroplasty 

      Chung, Yeun Goo; Tu, Duong; Franck, Debra; Gil, Eun Seok; Algarrahi, Khalid; Adam, Rosalyn M.; Kaplan, David L.; Estrada Jr., Carlos R.; Mauney, Joshua R. (Public Library of Science, 2014)
      Acellular scaffolds derived from Bombyx mori silk fibroin were investigated for their ability to support functional tissue regeneration in a rabbit model of urethra repair. A bi-layer silk fibroin matrix was fabricated by ...
    • Addition of Alanyl-Glutamine to Dialysis Fluid Restores Peritoneal Cellular Stress Responses – A First-In-Man Trial 

      Kratochwill, Klaus; Boehm, Michael; Herzog, Rebecca; Gruber, Katharina; Lichtenauer, Anton Michael; Kuster, Lilian; Csaicsich, Dagmar; Gleiss, Andreas; Alper, Seth L.; Aufricht, Christoph; Vychytil, Andreas (Public Library of Science, 2016)
      Background: Peritonitis and ultrafiltration failure remain serious complications of chronic peritoneal dialysis (PD). Dysfunctional cellular stress responses aggravate peritoneal injury associated with PD fluid exposure, ...
    • Adult Cardiac Progenitor Cell Aggregates Exhibit Survival Benefit Both In Vitro and In Vivo 

      Bauer, Michael; Kang, Lifeng; Qiu, Yiling; Wu, Jinhui; Peng, Michelle; Chen, Howard H.; Camci-Unal, Gulden; Bayomy, Ahmad F.; Sosnovik, David E.; Khademhosseini, Ali; Liao, Ronglih (Public Library of Science, 2012)
      Background: A major hurdle in the use of exogenous stems cells for therapeutic regeneration of injured myocardium remains the poor survival of implanted cells. To date, the delivery of stem cells into myocardium has largely ...
    • AKAP12 Mediates Barrier Functions of Fibrotic Scars during CNS Repair 

      Cha, Jong-Ho; Wee, Hee-Jun; Seo, Ji Hae; Ahn, Bum Ju; Park, Ji-Hyeon; Yang, Jun-Mo; Lee, Sae-Won; Kim, Eun Hee; Lee, Ok-Hee; Heo, Ji Hoe; Lee, Hyo-Jong; Gelman, Irwin H.; Arai, Ken; Lo, Eng H.; Kim, Kyu-Won (Public Library of Science, 2014)
      The repair process after CNS injury shows a well-organized cascade of three distinct stages: inflammation, new tissue formation, and remodeling. In the new tissue formation stage, various cells migrate and form the fibrotic ...
    • Analysis of a Mouse Skin Model of Tuberous Sclerosis Complex 

      Guo, Yanan; Dreier, John R.; Cao, Juxiang; Du, Heng; Granter, Scott R.; Kwiatkowski, David J. (Public Library of Science, 2016)
      Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor suppressor gene syndrome in which patients develop several types of tumors, including facial angiofibroma, subungual fibroma, Shagreen patch, angiomyolipomas, ...
    • An Analysis of the Role of the Indigenous Microbiota in Cholesterol Gallstone Pathogenesis 

      Fremont-Rahl, Jacqueline J.; Ge, Zhongming; Umana, Carlos; Whary, Mark T.; Taylor, Nancy S.; Muthupalani, Sureshkumar; Carey, Martin C.; Fox, James G.; Maurer, Kirk J. (Public Library of Science, 2013)
      Background and Aims Cholesterol gallstone disease is a complex process involving both genetic and environmental variables. No information exists regarding what role if any the indigenous gastrointestinal microbiota may ...
    • Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation 

      Dong, Yuanlin; Xu, Zhipeng; Wu, Xu; Zhang, Yiying; Xie, Zhongcong (Public Library of Science, 2012)
      Anesthetic isoflurane has been shown to promote Alzheimer’s disease (AD) neuropathogenesis by inducing caspase activation and accumulation of β-amyloid (Aβ). Phosphorylation of tau protein is another important feature of ...
    • Anion-Sensitive Fluorophore Identifies the Drosophila Swell-Activated Chloride Channel in a Genome-Wide RNA Interference Screen 

      Stotz, Stephanie Christine; Clapham, David Eldon (Public Library of Science, 2012)
      When cells swell in hypo-osmotic solutions, chloride-selective ion channels (\(Cl_{swell}\)) activate to reduce intracellular osmolality and prevent catastrophic cell rupture. Despite intensive efforts to assign a molecular ...
    • Astrocyte-Specific Disruption of SynCAM1 Signaling Results in ADHD-Like Behavioral Manifestations 

      Sandau, Ursula S.; Alderman, Zefora; Corfas, Gabriel; Ojeda, Sergio R.; Raber, Jacob (Public Library of Science, 2012)
      SynCAM1 is an adhesion molecule involved in synaptic differentiation and organization. SynCAM1 is also expressed in astroglial cells where it mediates astrocyte-to astrocyte and glial-neuronal adhesive communication. In ...
    • Autophagy in Idiopathic Pulmonary Fibrosis 

      Patel, Avignat Suresh; Lin, Ling; Geyer, Alexander; Haspel, Jeffrey Adam; An, Chang Hyeok; Cao, Jiaofei; Rosas, Ivan O.; Morse, Danielle (Public Library of Science, 2012)
      Background: Autophagy is a basic cellular homeostatic process important to cell fate decisions under conditions of stress. Dysregulation of autophagy impacts numerous human diseases including cancer and chronic obstructive ...
    • Basolateral Junction Proteins Regulate Competition for the Follicle Stem Cell Niche in the Drosophila Ovary 

      Kronen, Maria R.; Schoenfelder, Kevin P.; Klein, Allon M.; Nystul, Todd G. (Public Library of Science, 2014)
      Epithelial stem cells are routinely lost or damaged during adult life and must therefore be replaced to maintain homeostasis. Recent studies indicate that stem cell replacement occurs through neutral competition in many ...
    • Bilateral Nerve Alterations in a Unilateral Experimental Neurotrophic Keratopathy Model: A Lateral Conjunctival Approach for Trigeminal Axotomy 

      Yamaguchi, Takefumi; Turhan, Aslihan; Harris, Deshea L.; Hu, Kai; Prüss, Harald; von Andrian, Ulrich; Hamrah, Pedram (Public Library of Science, 2013)
      To study bilateral nerve changes in a newly developed novel mouse model for neurotrophic keratopathy by approaching the trigeminal nerve from the lateral fornix. Surgical axotomy of the ciliary nerve of the trigeminal nerve ...
    • Bioelectric Signaling Regulates Size in Zebrafish Fins 

      Perathoner, Simon; Daane, Jacob M.; Henrion, Ulrike; Seebohm, Guiscard; Higdon, Charles W.; Johnson, Stephen L.; Nüsslein-Volhard, Christiane; Harris, Matthew P. (Public Library of Science, 2014)
      The scaling relationship between the size of an appendage or organ and that of the body as a whole is tightly regulated during animal development. If a structure grows at a different rate than the rest of the body, this ...
    • Bmp7 Maintains Undifferentiated Kidney Progenitor Population and Determines Nephron Numbers at Birth 

      Tomita, Mayumi; Asada, Misako; Asada, Nariaki; Nakamura, Jin; Oguchi, Akiko; Higashi, Atsuko Y.; Endo, Shuichiro; Robertson, Elizabeth; Kimura, Takeshi; Kita, Toru; Economides, Aris N.; Kreidberg, Jordan; Yanagita, Motoko (Public Library of Science, 2013)
      The number of nephrons, the functional units of the kidney, varies among individuals. A low nephron number at birth is associated with a risk of hypertension and the progression of renal insufficiency. The molecular ...
    • Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures 

      Cleary, Ryan T.; Sun, Hongyun; Huynh, Thanhthao; Manning, Simon; Li, Yijun; Rotenberg, Alexander; Talos, Delia M.; Kahle, Kristopher Thomas; Jackson, Michele; Rakhade, Sanjay N.; Berry, Gerard T.; Jensen, Frances Elizabeth (Public Library of Science, 2013)
      Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na+-K+-2 Cl− cotransporter, NKCC1, and consequent paradoxical ...
    • c-Met Modulates RPE Migratory Response to Laser-Induced Retinal Injury 

      Kasaoka, Masataka; Ma, Jie; Lashkari, Kameran (Public Library of Science, 2012)
      Retinal laser injuries are often associated with aberrant migration of the retinal pigment epithelium (RPE), which can cause expansion of the scar beyond the confines of the original laser burn. In this study, we devised ...
    • C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress 

      Chiang, Wei-Chung; Tishkoff, Daniel X.; Yang, Bo; Grady, Joshua Terrence Wilson; Yu, Xiaokun; Mazer, Travis; Eckersdorff, Mark; Gygi, Steven P.; Lombard, David B.; Hsu, Ao-Lin (Public Library of Science, 2012)
      FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4—homolog of mammalian ...