Browsing HMS Scholarly Articles by Keyword "BACE1"

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    • Selective Amyloid-\(\beta\) Lowering Agents 

      Wolfe, Michael S. (BioMed Central, 2008)
      The amyloid-\(\beta\) peptide (A\(\beta\)), implicated in the pathogenesis of Alzheimer's disease (AD), is produced through sequential proteolysis of the A\(\beta\) precursor protein (APP) by \(\beta\)- and \(\gamma\)-secretases. ...

    • Synaptotagmins interact with APP and promote Aβ generation 

      Gautam, Vivek; D’Avanzo, Carla; Berezovska, Oksana; Tanzi, Rudolph E.; Kovacs, Dora M. (BioMed Central, 2015)
      Background: Accumulation of the β-amyloid peptide (Aβ) is a major pathological hallmark of Alzheimer’s disease (AD). Recent studies have shown that synaptic Aβ toxicity may directly impair synaptic function. However, ...