Browsing HMS Scholarly Articles by Keyword "Bioassays and Physiological Analysis"

Now showing items 1-20 of 22

    • CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis 

      Sosulski, Amanda; Horn, Heiko; Zhang, Lihua; Coletti, Caroline; Vathipadiekal, Vinod; Castro, Cesar M.; Birrer, Michael J.; Nagano, Osamu; Saya, Hideyuki; Lage, Kasper; Donahoe, Patricia K.; Pépin, David (Public Library of Science, 2016)
      CD44 is a transmembrane hyaluronic acid receptor gene that encodes over 100 different tissue-specific protein isoforms. The most ubiquitous, CD44 standard, has been used as a cancer stem cell marker in ovarian and other ...

    • Conscious Brain-to-Brain Communication in Humans Using Non-Invasive Technologies 

      Grau, Carles; Ginhoux, Romuald; Riera, Alejandro; Nguyen, Thanh Lam; Chauvat, Hubert; Berg, Michel; Amengual, Julià L.; Pascual-Leone, Alvaro; Ruffini, Giulio (Public Library of Science, 2014)
      Human sensory and motor systems provide the natural means for the exchange of information between individuals, and, hence, the basis for human civilization. The recent development of brain-computer interfaces (BCI) has ...

    • Effects of Aging on Genioglossus Motor Units in Humans 

      Saboisky, Julian P.; Stashuk, Daniel W.; Hamilton-Wright, Andrew; Trinder, John; Nandedkar, Sanjeev; Malhotra, Atul (Public Library of Science, 2014)
      The genioglossus is a major upper airway dilator muscle thought to be important in obstructive sleep apnea pathogenesis. Aging is a risk factor for obstructive sleep apnea although the mechanisms are unclear and the effects ...

    • Effects of Posture and Stimulus Spectral Composition on Peripheral Physiological Responses to Loud Sounds 

      Koch, Jennifer; Flemming, Jan; Zeffiro, Thomas; Rufer, Michael; Orr, Scott P.; Mueller-Pfeiffer, Christoph (Public Library of Science, 2016)
      In the “loud-tone” procedure, a series of brief, loud, pure-tone stimuli are presented in a task-free situation. It is an established paradigm for measuring autonomic sensitization in posttraumatic stress disorder (PTSD). ...

    • Globus Pallidus Externus Neurons Expressing parvalbumin Interconnect the Subthalamic Nucleus and Striatal Interneurons 

      Saunders, Arpiar; Huang, Kee Wui; Sabatini, Bernardo Luis (Public Library of Science, 2016)
      The globus pallidus externus (GP) is a nucleus of the basal ganglia (BG), containing GABAergic projection neurons that arborize widely throughout the BG, thalamus and cortex. Ongoing work seeks to map axonal projection ...

    • Incorporating and Compensating Cerebrospinal Fluid in Surface-Based Forward Models of Magneto- and Electroencephalography 

      Stenroos, Matti; Nummenmaa, Aapo (Public Library of Science, 2016)
      MEG/EEG source imaging is usually done using a three-shell (3-S) or a simpler head model. Such models omit cerebrospinal fluid (CSF) that strongly affects the volume currents. We present a four-compartment (4-C) boundary-element ...

    • Increased Early Processing of Task-Irrelevant Auditory Stimuli in Older Adults 

      Tusch, Erich S.; Alperin, Brittany R.; Holcomb, Phillip J.; Daffner, Kirk R. (Public Library of Science, 2016)
      The inhibitory deficit hypothesis of cognitive aging posits that older adults’ inability to adequately suppress processing of irrelevant information is a major source of cognitive decline. Prior research has demonstrated ...

    • Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study 

      Amdur, Richard L.; Mukherjee, Monica; Go, Alan; Barrows, Ian R.; Ramezani, Ali; Shoji, Jun; Reilly, Muredach P.; Gnanaraj, Joseph; Deo, Raj; Roas, Sylvia; Keane, Martin; Master, Steve; Teal, Valerie; Soliman, Elsayed Z.; Yang, Peter; Feldman, Harold; Kusek, John W.; Tracy, Cynthia M.; Raj, Dominic S. (Public Library of Science, 2016)
      Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with chronic kidney disease (CKD). In this study, we examined the association between inflammation and AF in 3,762 adults with CKD, enrolled in ...

    • Is COPD a Progressive Disease? A Long Term Bode Cohort Observation 

      de-Torres, Juan P.; Marín, Jose M.; Pinto-Plata, Víctor; Divo, Miguel; Sanchez-Salcedo, Pablo; Zagaceta, Jorge; Zulueta, Javier J.; Berto, Juan; Cabrera, Carlos; Celli, Bartolome R.; Casanova, Ciro (Public Library of Science, 2016)
      Background: The Global Initiative for Obstructive Lung Diseases (GOLD) defines COPD as a disease that is usually progressive. GOLD also provides a spirometric classification of airflow limitation. However, little is known ...

    • Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth 

      Johns, Lauren E.; Ferguson, Kelly K.; McElrath, Thomas F.; Mukherjee, Bhramar; Seely, Ellen W.; Meeker, John D. (Public Library of Science, 2017)
      Introduction: Overt thyroid disease in pregnancy is associated with numerous maternal and neonatal complications including preterm birth. Less is known about the contribution of trimester-specific subclinical alterations ...

    • Microarray Noninvasive Neuronal Seizure Recordings from Intact Larval Zebrafish 

      Meyer, Michaela; Dhamne, Sameer C.; LaCoursiere, Christopher M.; Tambunan, Dimira; Poduri, Annapurna; Rotenberg, Alexander (Public Library of Science, 2016)
      Zebrafish epilepsy models are emerging tools in experimental epilepsy. Zebrafish larvae, in particular, are advantageous because they can be easily genetically altered and used for developmental and drug studies since ...

    • MiR-449a Affects Epithelial Proliferation during the Pseudoglandular and Canalicular Phases of Avian and Mammal Lung Development 

      Sanford, Ethan L.; Choy, Kwong W.; Donahoe, Patricia K.; Tracy, Adam A.; Hila, Regis; Loscertales, Maria; Longoni, Mauro (Public Library of Science, 2016)
      Congenital diaphragmatic hernia is associated with pulmonary hypoplasia and respiratory distress, which result in high mortality and morbidity. Although several transgenic mouse models of lung hypoplasia exist, the role ...

    • Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration 

      Lee, Sang Goo; Huang, Mingqian; Obholzer, Nikolaus D.; Sun, Shan; Li, Wenyan; Petrillo, Marco; Dai, Pu; Zhou, Yi; Cotanche, Douglas A.; Megason, Sean G.; Li, Huawei; Chen, Zheng-Yi (Public Library of Science, 2016)
      Unlike mammals, the non-mammalian vertebrate inner ear can regenerate the sensory cells, hair cells, either spontaneously or through induction after hair cell loss, leading to hearing recovery. The mechanisms underlying ...

    • OTX2 Duplication Is Implicated in Hemifacial Microsomia 

      Zielinski, Dina; Markus, Barak; Sheikh, Mona; Gymrek, Melissa; Chu, Clement; Zaks, Marta; Srinivasan, Balaji; Hoffman, Jodi D.; Aizenbud, Dror; Erlich, Yaniv (Public Library of Science, 2014)
      Hemifacial microsomia (HFM) is the second most common facial anomaly after cleft lip and palate. The phenotype is highly variable and most cases are sporadic. We investigated the disorder in a large pedigree with five ...

    • The Outer Pore and Selectivity Filter of TRPA1 

      Christensen, Adam P.; Akyuz, Nurunisa; Corey, David P. (Public Library of Science, 2016)
      TRPA1 (transient-receptor-potential-related ion channel with ankyrin domains) is a direct receptor or indirect effector for a wide variety of nociceptive signals, and thus is a compelling target for development of analgesic ...

    • A Quantitative Electrophysiological Biomarker of Duplication 15q11.2-q13.1 Syndrome 

      Frohlich, Joel; Senturk, Damla; Saravanapandian, Vidya; Golshani, Peyman; Reiter, Lawrence T.; Sankar, Raman; Thibert, Ronald L.; DiStefano, Charlotte; Huberty, Scott; Cook, Edwin H.; Jeste, Shafali S. (Public Library of Science, 2016)
      Background: Duplications of 15q11.2-q13.1 (Dup15q syndrome) are highly penetrant for autism spectrum disorder (ASD). A distinct electrophysiological (EEG) pattern characterized by excessive activity in the beta band has ...

    • Relationship between C - Reactive Protein and Stroke: A Large Prospective Community Based Study 

      Liu, Yanfang; Wang, Jing; Zhang, Liqun; Wang, Chunxue; Wu, Jianwei; Zhou, Yong; Gao, Xiang; Wang, Anxin; Wu, Shouling; Zhao, Xingquan (Public Library of Science, 2014)
      Objective: Previous studies have suggested that C-reactive protein (CRP) was associated with risk of stroke. There were few studies in Asian population, or on stroke subtypes other than ischemic stroke. We thus investigated ...

    • Six-Nine Year Follow-Up of Deep Brain Stimulation for Obsessive-Compulsive Disorder 

      Fayad, Sarah M.; Guzick, Andrew G.; Reid, Adam M.; Mason, Dana M.; Bertone, Agustina; Foote, Kelly D.; Okun, Michael S.; Goodman, Wayne K.; Ward, Herbert E. (Public Library of Science, 2016)
      Objective: Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) region has shown promise as a neurosurgical intervention for adults with severe treatment-refractory obsessive-compulsive disorder ...

    • Spontaneous Neutrophil Migration Patterns during Sepsis after Major Burns 

      Jones, Caroline N.; Moore, Molly; Dimisko, Laurie; Alexander, Andrew; Ibrahim, Amir; Hassell, Bryan A.; Warren, H. Shaw; Tompkins, Ronald G.; Fagan, Shawn P.; Irimia, Daniel (Public Library of Science, 2014)
      Finely tuned to respond quickly to infections, neutrophils have amazing abilities to migrate fast and efficiently towards sites of infection and inflammation. Although neutrophils ability to migrate is perturbed in patients ...

    • Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes 

      Utheim, Tor Paaske; Islam, Rakibul; Fostad, Ida G.; Eidet, Jon R.; Sehic, Amer; Olstad, Ole K.; Dartt, Darlene A.; Messelt, Edward B.; Griffith, May; Pasovic, Lara (Public Library of Science, 2016)
      Purpose Storage of cultured human oral keratinocytes (HOK) allows for transportation of cultured transplants to eye clinics worldwide. In a previous study, one-week storage of cultured HOK was found to be superior with ...