Browsing HMS Scholarly Articles by Keyword "NMR spectroscopy"

Now showing items 1-3 of 3

    • Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR 

      Buratto, Roberto; Bornet, Aurélien; Milani, Jonas; Mammoli, Daniele; Vuichoud, Basile; Salvi, Nicola; Singh, Maninder; Laguerre, Aurélien; Passemard, Solène; Gerber-Lemaire, Sandrine; Jannin, Sami; Bodenhausen, Geoffrey (WILEY-VCH Verlag, 2014)
      Transverse and longitudinal relaxation times (T1ρ and T1) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be ...

    • Expression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell Line 

      Lutz, Norbert W.; Banerjee, Pallavi; Wilson, Brian J.; Ma, Jie; Cozzone, Patrick J.; Frank, Markus H. (Public Library of Science, 2016)
      We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for melanoma-initiating cells, on cellular metabolism. Metabolic profiles for ...

    • Metabolomic Profiling in Individuals with a Failing Kidney Allograft 

      Bassi, Roberto; Niewczas, Monika A.; Biancone, Luigi; Bussolino, Stefania; Merugumala, Sai; Tezza, Sara; D’Addio, Francesca; Ben Nasr, Moufida; Valderrama-Vasquez, Alessandro; Usuelli, Vera; De Zan, Valentina; El Essawy, Basset; Venturini, Massimo; Secchi, Antonio; De Cobelli, Francesco; Lin, Alexander; Chandraker, Anil; Fiorina, Paolo (Public Library of Science, 2017)
      Background: Alteration of certain metabolites may play a role in the pathophysiology of renal allograft disease. Methods: To explore metabolomic abnormalities in individuals with a failing kidney allograft, we analyzed by ...