Browsing HMS Scholarly Articles by Keyword "acquired drug resistance"
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HLA class I downregulation is associated with enhanced NK‐cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors
(John Wiley and Sons Inc., 2015)The frequent development of drug resistance to targeted therapies in cancer patients has stimulated interest in strategies counteracting resistance. Combining immunotherapies with targeted therapies is one such strategy. ... -
How drug resistance takes shape
(eLife Sciences Publications, Ltd, 2016)Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.