Browsing HMS Scholarly Articles by Keyword "animal model"

Now showing items 1-5 of 5

    • Assessing Murine Resistance Artery Function Using Pressure Myography 

      Shahid, Mohd; Buys, Emmanuel (MyJove Corporation, 2013)
      Pressure myograph systems are exquisitely useful in the functional assessment of small arteries, pressurized to a suitable transmural pressure. The near physiological condition achieved in pressure myography permits in-depth ...

    • Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres 

      Bunker, Shannon; Holeniewska, Joanna; Vijay, Sauparnika; Dahlmann-Noor, Annegret; Khaw, Peng; Ng, Yin-Shan; Shima, David; Foxton, Richard (MyJove Corporation, 2015)
      Progress in understanding the pathophysiology, and providing novel treatments for glaucoma is dependent on good animal models of the disease. We present here a protocol for elevating intraocular pressure (IOP) in the rat, ...

    • Production of Xenopus tropicalis Egg Extracts to Identify Microtubule-associated RNAs 

      Sharp, Judith A.; Blower, Mike D. (MyJove Corporation, 2013)
      Many organisms localize mRNAs to specific subcellular destinations to spatially and temporally control gene expression. Recent studies have demonstrated that the majority of the transcriptome is localized to a nonrandom ...

    • Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma 

      Simpson, R Mark; Bastian, Boris C; Michael, Helen T; Webster, Joshua D; Prasad, Manju L; Conway, Catherine M; Prieto, Victor M; Gary, Joy M; Goldschmidt, Michael H; Esplin, D Glen; Smedley, Rebecca C; Piris, Adriano; Meuten, Donald J; Kiupel, Matti; Lee, Chyi-Chia R; Ward, Jerrold M; Dwyer, Jennifer E; Davis, Barbara J; Anver, Miriam R; Molinolo, Alfredo A; Hoover, Shelley B; Rodriguez-Canales, Jaime; Hewitt, Stephen M (BlackWell Publishing Ltd, 2013)
      Melanoma represents a significant malignancy in humans and dogs. Different from genetically engineered models, sporadic canine melanocytic neoplasms share several characteristics with human disease that could make dogs a ...

    • Validity Assessment of 5 Day Repeated Forced-Swim Stress to Model Human Depression in Young-Adult C57BL/6J and BALB/cJ Mice 

      Mul, Joram D.; Zheng, Jia; Goodyear, Laurie J. (Society for Neuroscience, 2016)
      The development of animal models with construct, face, and predictive validity to accurately model human depression has been a major challenge. One proposed rodent model is the 5 d repeated forced swim stress (5d-RFSS) ...