Browsing HMS Scholarly Articles by Keyword "apolipoprotein B"
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Antisense inhibition of apoB synthesis with mipomersen reduces plasma apoC-III and apoC-III-containing lipoproteins
(American Society for Biochemistry & Molecular Biology (ASBMB), 2012)Mipomersen, an antisense oligonucleotide that reduces hepatic production of apoB, has been shown in phase 2 studies to decrease plasma apoB, LDL cholesterol (LDL-C), and triglycerides. ApoC-III inhibits VLDL and LDL ...