Browsing HMS Scholarly Articles by Keyword "asthma"
Now showing items 1-20 of 22
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Adiponectin Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling
(American Thoracic Society, 2009)Obesity is associated with an increased incidence and severity of asthma, as well as other lung disorders, such as pulmonary hypertension. Adiponectin (APN), an antiinflammatory adipocytokine, circulates at lower levels ... -
Asthma Associates With Human Abdominal Aortic Aneurysm and RuptureSignificance
(Ovid Technologies (Wolters Kluwer Health), 2016)Objective—Both asthma and abdominal aortic aneurysms (AAA) involve inflammation. It remains unknown whether these diseases interact. Approach and Results—Databases analyzed included Danish National Registry of Patients, ... -
Asthma Treatments and Mental Health Visits After a Food and Drug Administration Label Change for Leukotriene Inhibitors
(Elsevier BV, 2015)Purpose In 2009, the US Food and Drug Administration (FDA) mandated a label change for leukotriene inhibitors (LTIs) to include neuropsychiatric adverse events (eg, depression and suicidality) as a precaution. This study ... -
Autonomic Effects of Controlled Fine Particulate Exposure in Young Healthy Adults: Effect Modification by Ozone
(National Institute of Environmental Health Sciences, 2009)Background: Human controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are modified by ... -
A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research
(National Institute of Environmental Health Sciences, 2006)Relative to research on effects of environmental exposures on exacerbation of existing asthma, little research on incident asthma and environmental exposures has been conducted. However, this research is needed to better ... -
Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses
(BioMed Central, 2001)The hygiene hypothesis states that childhood asthma develops as a result of decreased exposure to infectious agents during infancy and early childhood. This results in the persistence of the neonatal T helper lymphocyte 2 ... -
Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts
(The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease, 2014)Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification ... -
Environmental tobacco smoke, indoor allergens, and childhood asthma.
(2000)Both environmental tobacco smoke and indoor allergens can exacerbate already established childhood albeit primarily through quite disparate mechanisms. In infancy and childhood, environmental tobacco smoke (ETS) exposure ... -
Genes to Diseases (G2D) Computational Method to Identify Asthma Candidate Genes
(Public Library of Science, 2008)Asthma is a complex trait for which different strategies have been used to identify its environmental and genetic predisposing factors. Here, we describe a novel methodological approach to select candidate genes for asthma ... -
Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children
(Public Library of Science, 2009)Many candidate genes have been studied for asthma, but replication has varied. Novel candidate genes have been identified for various complex diseases using genome-wide association studies (GWASs). We conducted a GWAS in ... -
A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes
(Elsevier BV, 2014)Background: Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes ... -
Home endotoxin exposure and wheeze in infants: correction for bias due to exposure measurement error
(National Institute of Environmental Health Sciences, 2005)Exposure to elevated levels of endotoxin in family-room dust was previously observed to be significantly associated with increased wheeze in the first year of life among a cohort of 404 children in the Boston, Massachusetts, ... -
IL-17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity
(2014)Obesity is associated with the development of asthma and considerable asthma-related healthcare utilization. To understand the immunological pathways that lead to obesity-associated asthma, we fed mice a high fat diet for ... -
The influence of atopy and asthma on immune responses in inner‐city adults
(John Wiley and Sons Inc., 2016)Abstract Asthma in the inner‐city population is usually atopic in nature, and is associated with significant morbidity and mortality. However, the underlying immune abnormalities that underlie asthma in urban adults have ... -
Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life
(2016)Asthma often progresses from early episodes of insults. How early life events connect to long-term airway dysfunction remains poorly understood. We demonstrated previously that increased neurotrophin 4 (NT4) levels following ... -
The metabolomics of asthma control: a promising link between genetics and disease
(John Wiley & Sons, Ltd, 2015)Short-acting β agonists (e.g., albuterol) are the most commonly used medications for asthma, a disease that affects over 300 million people in the world. Metabolomic profiling of asthmatics taking β agonists presents a new ... -
Pesticide spraying for West Nile virus control and emergency department asthma visits in New York City, 2000
(National Institue of Environmental Health Sciences, 2004)Pyrethroid pesticides were applied via ground spraying to residential neighborhoods in New York City during July–September 2000 to control mosquito vectors of West Nile virus (WNV). Case reports link pyrethroid exposure ... -
A polymorphism in HLA-G modifies statin benefit in asthma
(2014)Several reports have shown that statin treatment benefits patients with asthma, however inconsistent effects have been observed. The mir-152 family (148a, 148b and 152) has been implicated in asthma. These microRNAs suppress ... -
Reflux Related Hospital Admissions after Fundoplication in Children with Neurological Impairment: Retrospective Cohort Study
(BMJ Publishing Group Ltd., 2009)Objective: To examine the impact of fundoplication on reflux related hospital admissions for children with neurological impairment. Design: Retrospective, observational cohort study. Setting: 42 children’s hospitals in the ... -
Resolvin D1 and Resolvin E1 Promote the Resolution of Allergic Airway Inflammation via Shared and Distinct Molecular Counter-Regulatory Pathways
(Frontiers Media S.A., 2012)Resolvins are generated from omega-3 fatty acids during inflammatory responses in the lung. These natural mediators interact with specific receptors to decrease lung inflammation and promote its resolution in healthy ...