Browsing HMS Scholarly Articles by Keyword "pharmacogenomics"

Now showing items 1-7 of 7

    • CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids 

      Dahlin, Amber; Denny, Joshua; Roden, Dan M.; Brilliant, Murray H.; Ingram, Christie; Kitchner, Terrie E.; Linneman, James G.; Shaffer, Christian M.; Weeke, Peter; Xu, Hua; Kubo, Michiaki; Tamari, Mayumi; Clemmer, George L.; Ziniti, John; McGeachie, Michael J.; Tantisira, Kelan G.; Weiss, Scott T.; Wu, Ann Chen (John Wiley and Sons Inc., 2015)
      Abstract Inhaled corticosteroids (ICS) are the most effective controller medications for asthma, and variability in ICS response is associated with genetic variation. Despite ICS treatment, some patients with poor asthma ...

    • Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies 

      Nolte, Ilja M.; Wallace, Chris; Newhouse, Stephen J.; Waggott, Daryl; Fu, Jingyuan; Soranzo, Nicole; Gwilliam, Rhian; Deloukas, Panos; Savelieva, Irina; Zheng, Dongling; Dalageorgou, Chrysoula; Farrall, Martin; Samani, Nilesh J.; Brown, Morris; Dominiczak, Anna; Lathrop, Mark; Zeggini, Eleftheria; Wain, Louise V.; Eijgelsheim, Mark; Pfeufer, Arne; Sanna, Serena; Arking, Dan E.; Asselbergs, Folkert W.; Spector, Tim D.; Carter, Nicholas D.; Jeffery, Steve; Tobin, Martin; Caulfield, Mark; Snieder, Harold; Munroe, Patricia B.; Jamshidi, Yalda; Connell, John; Newton-Cheh, Christopher Holmes; Rice, Kenneth Robert; de Bakker, Paul I Wen; Paterson, Andrew D. (Public Library of Science, 2009)
      To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide ...

    • Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval 

      Avery, Christy L.; Sitlani, Colleen M.; Arking, Dan E.; Arnett, Donna K.; Bis, Joshua C.; Boerwinkle, Eric; Buckley, Brendan M.; Chen, Y.-D. Ida; de Craen, Anton JM; Eijgelsheim, Mark; Enquobahrie, Daniel; Evans, Daniel S.; Ford, Ian; Garcia, Melissa E.; Gudnason, Vilmundur; Harris, Tamara B.; Heckbert, Susan R.; Hochner, Hagit; Hofman, Albert; Hsueh, Wen-Chi; Isaacs, Aaron; Jukema, J. Wouter; Knekt, Paul; Kors, Jan A.; Krijthe, Bouwe P.; Kristiansson, Kati; Laaksonen, Maarit; Liu, Yongmei; Li, Xiaohui; MacFarlane, Peter W.; Newton-Cheh, Christopher; Nieminen, Markku S.; Oostra, Ben A.; Peloso, Gina M.; Porthan, Kimmo; Rice, Kenneth; Rivadeneira, Fernando F.; Rotter, Jerome I.; Salomaa, Veikko; Sattar, Naveed; Siscovick, David S.; Slagboom, P. Eline; Smith, Albert V.; Sotoodehnia, Nona; Stott, David J.; Stricker, Bruno H.; Stürmer, Til; Trompet, Stella; Uitterlinden, Andre G.; van Duijn, Cornelia M.; Westendorp, Rudi GJ; Witteman, Jacqueline C.; Whitsel, Eric A.; Psaty, Bruce M. (2013)
      Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the “missing heritability” of complex traits. Here, we describe four independent analyses ...

    • Genome-wide Association of Lipid-lowering Response to Statins in Combined Study Populations 

      Barber, Mathew J.; Mangravite, Lara M.; Hyde, Craig L.; McCarty, Catherine A.; Li, Xiaohui; Wilke, Russell A.; Rieder, Mark J.; Williams, Paul T.; Chatterjee, Aurobindo; Rotter, Jerome I.; Nickerson, Deborah A.; Stephens, Matthew; Krauss, Ronald M.; Zanger, Ulrich; Chasman, Daniel Ian; Smith, Joshua D.; Ridker, Paul M. (Public Library of Science, 2010)
      Background: Statins effectively lower total and plasma LDL-cholesterol, but the magnitude of decrease varies among individuals. To identify single nucleotide polymorphisms (SNPs) contributing to this variation, we performed ...

    • Network-based identification of microRNAs as potential pharmacogenomic biomarkers for anticancer drugs 

      Li, Jie; Lei, Kecheng; Wu, Zengrui; Li, Weihua; Liu, Guixia; Liu, Jianwen; Cheng, Feixiong; Tang, Yun (Impact Journals LLC, 2016)
      As the recent development of high-throughput technologies in cancer pharmacogenomics, there is an urgent need to develop new computational approaches for comprehensive identification of new pharmacogenomic biomarkers, such ...

    • Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols 

      Moore, Carrie B.; Verma, Anurag; Pendergrass, Sarah; Verma, Shefali S.; Johnson, Daniel H.; Daar, Eric S.; Gulick, Roy M.; Haubrich, Richard; Robbins, Gregory K.; Ritchie, Marylyn D.; Haas, David W. (Oxford University Press, 2014)
      Background. Phenome-Wide Association Studies (PheWAS) identify genetic associations across multiple phenotypes. Clinical trials offer opportunities for PheWAS to identify pharmacogenomic associations. We describe the first ...

    • Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy 

      Nitta, Masayuki; Stommel, Jayne; Ng, Kimberly; Kesari, Santosh; Furnari, Frank; Hoadley, Katherine A.; Cavenee, Webster K.; Kozono, David Eiichi; Kennedy, Richard; Zinn, Pascal Olivier; Kushwaha, Deepa S; Chin, Lynda; DePinho, Ronald A.; D'Andrea, Alan David; Chen, Clark Chin-Chung (Public Library of Science, 2010)
      Despite the critical role of Epidermal Growth Factor Receptor (EGFR) in glioblastoma pathogenesis [1], [2], EGFR targeted therapies have achieved limited clinical efficacy [3]. Here we propose an alternate therapeutic ...