Now showing items 1-2 of 2

    • Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28 

      Zürcher, Nicole R.; Loggia, Marco L.; Lawson, Robert; Chonde, Daniel B.; Izquierdo-Garcia, David; Yasek, Julia E.; Akeju, Oluwaseun; Catana, Ciprian; Rosen, Bruce R.; Cudkowicz, Merit E.; Hooker, Jacob M.; Atassi, Nazem (Elsevier, 2015)
      Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo ...
    • PET Imaging of Fatty Acid Amide Hydrolase with [18F]DOPP in Nonhuman Primates 

      Rotstein, Benjamin H.; Wey, Hsiao-Ying; Shoup, Timothy M.; Wilson, Alan A.; Liang, Steven H.; Hooker, Jacob M.; Vasdev, Neil (American Chemical Society, 2014)
      Fatty acid amide hydrolase (FAAH) regulates endocannabinoid signaling. [11C]CURB, an irreversibly binding FAAH inhibitor, has been developed for clinical research imaging with PET. However, no fluorine-18 labeled radiotracer ...