Browsing HMS Scholarly Articles by Keyword "Alzheimer"

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    • The amyloid hypothesis of Alzheimer's disease at 25 years 

      Selkoe, Dennis J; Hardy, John (John Wiley and Sons Inc., 2016)
      Abstract Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 ...

    • Human tau increases amyloid β plaque size but not amyloid β‐mediated synapse loss in a novel mouse model of Alzheimer's disease 

      Jackson, Rosemary J.; Rudinskiy, Nikita; Herrmann, Abigail G.; Croft, Shaun; Kim, JeeSoo Monica; Petrova, Veselina; Ramos‐Rodriguez, Juan Jose; Pitstick, Rose; Wegmann, Susanne; Garcia‐Alloza, Monica; Carlson, George A.; Hyman, Bradley T.; Spires‐Jones, Tara L. (John Wiley and Sons Inc., 2016)
      Abstract Alzheimer's disease is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, ...