Now showing items 1-7 of 7

    • Cathepsin S Signals via PAR2 and Generates a Novel Tethered Ligand Receptor Agonist 

      Elmariah, Sarina B.; Reddy, Vemuri B.; Lerner, Ethan A. (Public Library of Science, 2014)
      Protease-activated receptor-2 is widely expressed in mammalian epithelial, immune and neural tissues. Cleavage of PAR2 by serine proteases leads to self-activation of the receptor by the tethered ligand SLIGRL. The ...
    • Exacerbated experimental arthritis in Wiskott–Aldrich syndrome protein deficiency: Modulatory role of regulatory B cells 

      Bouma, Gerben; Carter, Natalie A; Recher, Mike; Malinova, Dessislava; Adriani, Marsilio; Notarangelo, Luigi D; Burns, Siobhan O; Mauri, Claudia; Thrasher, Adrian J (BlackWell Publishing Ltd, 2014)
      Patients deficient in the cytoskeletal regulator Wiskott–Aldrich syndrome protein (WASp) are predisposed to varied autoimmunity, suggesting it has an important controlling role in participating cells. IL-10-producing ...
    • Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study 

      Prins, Bram. P.; Abbasi, Ali; Wong, Anson; Vaez, Ahmad; Nolte, Ilja; Franceschini, Nora; Stuart, Philip E.; Guterriez Achury, Javier; Mistry, Vanisha; Bradfield, Jonathan P.; Valdes, Ana M.; Bras, Jose; Shatunov, Aleksey; Lu, Chen; Han, Buhm; Raychaudhuri, Soumya; Bevan, Steve; Mayes, Maureen D.; Tsoi, Lam C.; Evangelou, Evangelos; Nair, Rajan P.; Grant, Struan F. A.; Polychronakos, Constantin; Radstake, Timothy R. D.; van Heel, David A.; Dunstan, Melanie L.; Wood, Nicholas W.; Al-Chalabi, Ammar; Dehghan, Abbas; Hakonarson, Hakon; Markus, Hugh S.; Elder, James T.; Knight, Jo; Arking, Dan E.; Spector, Timothy D.; Koeleman, Bobby P. C.; van Duijn, Cornelia M.; Martin, Javier; Morris, Andrew P.; Weersma, Rinse K.; Wijmenga, Cisca; Munroe, Patricia B.; Perry, John R. B.; Pouget, Jennie G.; Jamshidi, Yalda; Snieder, Harold; Alizadeh, Behrooz Z. (Public Library of Science, 2016)
      Background: C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. Methods and Findings: We performed Mendelian ...
    • A Novel Approach to Identifying Trajectories of Mobility Change in Older Adults 

      Ward, Rachel E.; Beauchamp, Marla K.; Latham, Nancy K.; Leveille, Suzanne G.; Percac-Lima, Sanja; Kurlinski, Laura; Ni, Pengsheng; Goldstein, Richard; Jette, Alan M.; Bean, Jonathan F. (Public Library of Science, 2016)
      Objectives: To validate trajectories of late-life mobility change using a novel approach designed to overcome the constraints of modest sample size and few follow-up time points. Methods: Using clinical reasoning and ...
    • Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study 

      Cornelissen, Laura; Donado, Carolina; Kim, Joseph; Chiel, Laura; Zurakowski, David; Logan, Deirdre E; Meier, Petra; Sethna, Navil F; Blankenburg, Markus; Zernikow, Boris; Sundel, Robert P; Berde, Charles B (BioMed Central, 2014)
      Background: Juvenile Idiopathic Arthritis (JIA) is the most common cause of non-infectious joint inflammation in children. Synovial inflammation results in pain, swelling and stiffness. Animal and adult human studies ...
    • PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage 

      Vasheghani, Faezeh; Zhang, Yue; Li, Ying-Hua; Blati, Meryem; Fahmi, Hassan; Lussier, Bertrand; Roughley, Peter; Lagares, David; Endisha, Helal; Saffar, Bahareh; Lajeunesse, Daniel; Marshall, Wayne K; Rampersaud, Y Raja; Mahomed, Nizar N; Gandhi, Rajiv; Pelletier, Jean-Pierre; Martel-Pelletier, Johanne; Kapoor, Mohit (BMJ Publishing Group, 2015)
      Objectives: We have previously shown that peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is essential for the normal growth and development of cartilage. In the present study, we created ...
    • Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1 

      Ge, Xianpeng; Ritter, Susan Y.; Tsang, Kelly; Shi, Ruirui; Takei, Kohtaro; Aliprantis, Antonios O. (Public Library of Science, 2016)
      Cartilage acidic protein 1 (CRTAC1) was recently identified as an elevated protein in the synovial fluid of patients with osteoarthritis (OA) by a proteomic analysis. This gene is also upregulated in both human and mouse ...