Browsing HMS Scholarly Articles by Keyword "Arthritis"
Now showing items 1-7 of 7
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Cathepsin S Signals via PAR2 and Generates a Novel Tethered Ligand Receptor Agonist
(Public Library of Science, 2014)Protease-activated receptor-2 is widely expressed in mammalian epithelial, immune and neural tissues. Cleavage of PAR2 by serine proteases leads to self-activation of the receptor by the tethered ligand SLIGRL. The ... -
Exacerbated experimental arthritis in Wiskott–Aldrich syndrome protein deficiency: Modulatory role of regulatory B cells
(BlackWell Publishing Ltd, 2014)Patients deficient in the cytoskeletal regulator Wiskott–Aldrich syndrome protein (WASp) are predisposed to varied autoimmunity, suggesting it has an important controlling role in participating cells. IL-10-producing ... -
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study
(Public Library of Science, 2016)Background: C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. Methods and Findings: We performed Mendelian ... -
A Novel Approach to Identifying Trajectories of Mobility Change in Older Adults
(Public Library of Science, 2016)Objectives: To validate trajectories of late-life mobility change using a novel approach designed to overcome the constraints of modest sample size and few follow-up time points. Methods: Using clinical reasoning and ... -
Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study
(BioMed Central, 2014)Background: Juvenile Idiopathic Arthritis (JIA) is the most common cause of non-infectious joint inflammation in children. Synovial inflammation results in pain, swelling and stiffness. Animal and adult human studies ... -
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
(BMJ Publishing Group, 2015)Objectives: We have previously shown that peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is essential for the normal growth and development of cartilage. In the present study, we created ... -
Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1
(Public Library of Science, 2016)Cartilage acidic protein 1 (CRTAC1) was recently identified as an elevated protein in the synovial fluid of patients with osteoarthritis (OA) by a proteomic analysis. This gene is also upregulated in both human and mouse ...