Now showing items 1-20 of 121

    • 1,4-Disubstituted-[1,2,3]triazolyl-Containing Analogues of MT-II: Design, Synthesis, Conformational Analysis, and Biological Activity 

      Testa, Chiara; Scrima, Mario; Grimaldi, Manuela; D’Ursi, Anna M.; Dirain, Marvin L.; Lubin-Germain, Nadège; Singh, Anamika; Haskell-Luevano, Carrie; Chorev, Michael; Rovero, Paolo; Papini, Anna M. (American Chemical Society, 2014)
      Side chain-to-side chain cyclizations represent a strategy to select a family of bioactive conformations by reducing the entropy and enhancing the stabilization of functional ligand-induced receptor conformations. This ...
    • Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state 

      Fallahi‐Sichani, Mohammad; Becker, Verena; Izar, Benjamin; Baker, Gregory J; Lin, Jia‐Ren; Boswell, Sarah A; Shah, Parin; Rotem, Asaf; Garraway, Levi A; Sorger, Peter K (John Wiley and Sons Inc., 2017)
      Abstract Treatment of BRAF‐mutant melanomas with MAP kinase pathway inhibitors is paradigmatic of the promise of precision cancer therapy but also highlights problems with drug resistance that limit patient benefit. We use ...
    • Antimicrobial Chemicals Are Associated with Elevated Antibiotic Resistance Genes in the Indoor Dust Microbiome 

      Hartmann, Erica M.; Hickey, Roxana; Hsu, Tiffany; Betancourt Román, Clarisse M.; Chen, Jing; Schwager, Randall; Kline, Jeff; Brown, G. Z.; Halden, Rolf U.; Huttenhower, Curtis; Green, Jessica L. (American Chemical Society, 2016)
      Antibiotic resistance is increasingly widespread, largely due to human influence. Here, we explore the relationship between antibiotic resistance genes and the antimicrobial chemicals triclosan, triclocarban, and methyl-, ...
    • Autoantibody Signature for the Serologic Detection of Ovarian Cancer 

      Anderson, Karen S.; Cramer, Daniel W.; Sibani, Sahar; Wallstrom, Garrick; Wong, Jessica; Park, Jin; Qiu, Ji; Vitonis, Allison; LaBaer, Joshua (American Chemical Society, 2014)
      Sera from patients with ovarian cancer contain autoantibodies (AAb) to tumor-derived proteins that are potential biomarkers for early detection. To detect AAb, we probed high-density programmable protein microarrays (NAPPA) ...
    • Bacterial protein translocation requires only one copy of the SecY complex in vivo 

      Park, Eunyong; Rapoport, Tom A. (The Rockefeller University Press, 2012)
      The transport of proteins across the plasma membrane in bacteria requires a channel formed from the SecY complex, which cooperates with either a translating ribosome in cotranslational translocation or the SecA ATPase in ...
    • Biased Multicomponent Reactions to Develop Novel Bromodomain Inhibitors 

      McKeown, Michael R; Shaw, Daniel L; Fu, Harry; Liu, Shuai; Xu, Xiang; Marineau, Jason J; Huang, Yibo; Zhang, Xiaofeng; Buckley, Dennis L; Kadam, Asha; Zhang, Zijuan; Blacklow, Stephen C; Qi, Jun; Zhang, Wei; Bradner, James E (American Chemical Society, 2014)
      BET bromodomain inhibition has contributed new insights into gene regulation and emerged as a promising therapeutic strategy in cancer. Structural analogy of early methyl-triazolo BET inhibitors has prompted a need for ...
    • BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis 

      Broering, Tyler J.; Alavattam, Kris G.; Sadreyev, Ruslan I.; Ichijima, Yosuke; Kato, Yasuko; Hasegawa, Kazuteru; Camerini-Otero, R. Daniel; Lee, Jeannie T.; Andreassen, Paul R.; Namekawa, Satoshi H. (The Rockefeller University Press, 2014)
      During meiosis, DNA damage response (DDR) proteins induce transcriptional silencing of unsynapsed chromatin, including the constitutively unsynapsed XY chromosomes in males. DDR proteins are also implicated in double strand ...
    • The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation 

      Schwarz, Dianne S.; Blower, Michael D. (The Rockefeller University Press, 2014)
      How cells shape and remodel organelles in response to cellular signals is a poorly understood process. Using Xenopus laevis egg extract, we found that increases in cytosolic calcium lead to the activation of an endogenous ...
    • Cell-Envelope Remodeling as a Determinant of Phenotypic Antibacterial Tolerance in Mycobacterium tuberculosis 

      Larrouy-Maumus, Gérald; Marino, Leonardo B.; Madduri, Ashoka V. R.; Ragan, T. J.; Hunt, Debbie M.; Bassano, Lucrezia; Gutierrez, Maximiliano G.; Moody, D. Branch; Pavan, Fernando R.; de Carvalho, Luiz Pedro S. (American Chemical Society, 2016)
      The mechanisms that lead to phenotypic antibacterial tolerance in bacteria remain poorly understood. We investigate whether changes in NaCl concentration toward physiologically higher values affect antibacterial efficacy ...
    • CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field 

      Lee, Jumin; Cheng, Xi; Swails, Jason M.; Yeom, Min Sun; Eastman, Peter K.; Lemkul, Justin A.; Wei, Shuai; Buckner, Joshua; Jeong, Jong Cheol; Qi, Yifei; Jo, Sunhwan; Pande, Vijay S.; Case, David A.; Brooks, Charles L.; MacKerell, Alexander D.; Klauda, Jeffery B.; Im, Wonpil (American Chemical Society, 2015)
      Proper treatment of nonbonded interactions is essential for the accuracy of molecular dynamics (MD) simulations, especially in studies of lipid bilayers. The use of the CHARMM36 force field (C36 FF) in different MD simulation ...
    • Clinicopathological Features of Gallbladder Papillary Adenocarcinoma 

      Wan, Xueshuai; Zhang, Haohai; Chen, Cuimin; Yang, Xiaobo; Wang, Anqiang; Zhu, Chengpei; Fu, Lilan; Miao, Ruoyu; He, Lian; Yang, Huayu; Zhao, Haitao; Sang, Xinting (Wolters Kluwer Health, 2014)
      Abstract Although patients with gallbladder papillary adenocarcinoma (GBPA) appear to have better prognoses than patients with other pathological subtypes of gallbladder carcinoma (GBC), the clinicopathological features ...
    • Closing the delivery gaps in pediatric HIV care in Togo, West Africa: using the care delivery value chain framework to direct quality improvement 

      Fiori, Kevin; Schechter, Jennifer; Dey, Monica; Braganza, Sandra; Rhatigan, Joseph; Houndenou, Spero; Gbeleou, Christophe; Palerbo, Emmanuel; Tchangani, Elfamozo; Lopez, Andrew; Bensen, Emily; Hirschhorn, Lisa R. (Taylor & Francis, 2016)
      ABSTRACT Providing quality care for all children living with HIV/AIDS remains a global challenge and requires the development of new healthcare delivery strategies. The care delivery value chain (CDVC) is a framework that ...
    • Combining Amine Metabolomics and Quantitative Proteomics of Cancer Cells Using Derivatization with Isobaric Tags 

      Murphy, J. Patrick; Everley, Robert A.; Coloff, Jonathan L.; Gygi, Steven P. (American Chemical Society, 2014)
      Quantitative metabolomics and proteomics technologies are powerful approaches to explore cellular metabolic regulation. Unfortunately, combining the two technologies typically requires different LC-MS setups for sensitive ...
    • Complete integrin headpiece opening in eight steps 

      Zhu, Jieqing; Zhu, Jianghai; Springer, Timothy A. (The Rockefeller University Press, 2013)
      Carefully soaking crystals with Arg-Gly-Asp (RGD) peptides, we captured eight distinct RGD-bound conformations of the αIIbβ3 integrin headpiece. Starting from the closed βI domain conformation, we saw six intermediate βI ...
    • Controlled Growth of Filamentous Fatty Acid Vesicles under Flow 

      Hentrich, Christian; Szostak, Jack W. (American Chemical Society, 2014)
      The earliest forms of cellular life would have required a membrane compartment capable of growth and division. Fatty acid vesicles are an attractive model of protocell membranes, as they can grow into filamentous vesicles ...
    • Deacetylation of p53 induces autophagy by suppressing Bmf expression 

      Contreras, Amelia U.; Mebratu, Yohannes; Delgado, Monica; Montano, Gilbert; Hu, Chien-an A.; Ryter, Stefan W.; Choi, Augustine M.K.; Lin, Yuting; Xiang, Jialing; Chand, Hitendra; Tesfaigzi, Yohannes (The Rockefeller University Press, 2013)
      Interferon γ (IFN-γ)–induced cell death is mediated by the BH3-only domain protein, Bik, in a p53-independent manner. However, the effect of IFN-γ on p53 and how this affects autophagy have not been reported. The present ...
    • Design of Lipid Nanocapsule Delivery Vehicles for Multivalent Display of Recombinant Env Trimers in HIV Vaccination 

      Pejawar-Gaddy, Sharmila; Kovacs, James M.; Barouch, Dan H.; Chen, Bing; Irvine, Darrell J. (American Chemical Society, 2014)
      Immunization strategies that elicit antibodies capable of neutralizing diverse virus strains will likely be an important part of a successful vaccine against HIV. However, strategies to promote robust humoral responses ...
    • Developing family interventions for adolescent HIV prevention in South Africa 

      Kuo, Caroline; Atujuna, Millicent; Mathews, Catherine; Stein, Dan J.; Hoare, Jacqueline; Beardslee, William; Operario, Don; Cluver, Lucie; K. Brown, Larry (Taylor & Francis, 2016)
      ABSTRACT Adolescents and young people account for 40% of all new HIV infections each year, with South Africa one of the hardest hit countries, and having the largest population of people living with HIV. Although adolescent ...
    • Developmental regulation of myeloerythroid progenitor function by the Lin28b–let-7–Hmga2 axis 

      Rowe, R. Grant; Wang, Leo D.; Coma, Silvia; Han, Areum; Mathieu, Ronald; Pearson, Daniel S.; Ross, Samantha; Sousa, Patricia; Nguyen, Phi T.; Rodriguez, Antony; Wagers, Amy J.; Daley, George Q. (The Rockefeller University Press, 2016)
      For appropriate development, tissue and organ system morphogenesis and maturation must occur in synchrony with the overall developmental requirements of the host. Mistiming of such developmental events often results in ...
    • Developmental Self-Assembly of a DNA Tetrahedron 

      Sadowski, John P.; Calvert, Colby R.; Zhang, David Yu; Pierce, Niles A.; Yin, Peng (American Chemical Society, 2014)
      Kinetically controlled isothermal growth is fundamental to biological development, yet it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed ...