Now showing items 1-6 of 6

    • Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet 

      Senger, Donald R.; Li, Dan; Jaminet, Shou-Ching; Cao, Shugeng (Public Library of Science, 2016)
      The Nrf2 (NFE2L2) cell defense pathway protects against oxidative stress and disorders including cancer and neurodegeneration. Although activated modestly by oxidative stress alone, robust activation of the Nrf2 defense ...
    • Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth 

      Kiselinova, Maja; De Spiegelaere, Ward; Buzon, Maria Jose; Malatinkova, Eva; Lichterfeld, Mathias; Vandekerckhove, Linos (Public Library of Science, 2016)
      The persistence of a reservoir of latently infected CD4 T cells remains one of the major obstacles to cure HIV. Numerous strategies are being explored to eliminate this reservoir. To translate these efforts into clinical ...
    • Minimally Symptomatic Infection in an Ebola ‘Hotspot’: A Cross-Sectional Serosurvey 

      Richardson, Eugene T.; Kelly, J. Daniel; Barrie, Mohamed Bailor; Mesman, Annelies W.; Karku, Sahr; Quiwa, Komba; Marsh, Regan H.; Koedoyoma, Songor; Daboh, Fodei; Barron, Kathryn P.; Grady, Michael; Tucker, Elizabeth; Dierberg, Kerry L.; Rutherford, George W.; Barry, Michele; Jones, James Holland; Murray, Megan B.; Farmer, Paul E. (Public Library of Science, 2016)
      Introduction: Evidence for minimally symptomatic Ebola virus (EBOV) infection is limited. During the 2013–16 outbreak in West Africa, it was not considered epidemiologically relevant to published models or projections of ...
    • Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors 

      Vafai, Scott B.; Mevers, Emily; Higgins, Kathleen W.; Fomina, Yevgenia; Zhang, Jianming; Mandinova, Anna; Newman, David; Shaw, Stanley Y.; Clardy, Jon; Mootha, Vamsi K. (Public Library of Science, 2016)
      Deficiency of mitochondrial complex I is encountered in both rare and common diseases, but we have limited therapeutic options to treat this lesion to the oxidative phosphorylation system (OXPHOS). Idebenone and menadione ...
    • Performance of the GeneXpert Ebola Assay for Diagnosis of Ebola Virus Disease in Sierra Leone: A Field Evaluation Study 

      Semper, Amanda E.; Broadhurst, M. Jana; Richards, Jade; Foster, Geraldine M.; Simpson, Andrew J. H.; Logue, Christopher H.; Kelly, J. Daniel; Miller, Ann; Brooks, Tim J. G.; Murray, Megan; Pollock, Nira R. (Public Library of Science, 2016)
      Background: Throughout the Ebola virus disease (EVD) epidemic in West Africa, field laboratory testing for EVD has relied on complex, multi-step real-time reverse transcription PCR (RT-PCR) assays; an accurate sample-to-answer ...
    • The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1 

      Li, Gang; Cunin, Pierre; Wu, Di; Diogo, Dorothée; Yang, Yu; Okada, Yukinori; Plenge, Robert M.; Nigrovic, Peter A. (Public Library of Science, 2016)
      Understanding the implications of genome-wide association studies (GWAS) for disease biology requires both identification of causal variants and definition of how these variants alter gene function. The non-coding triallelic ...