Browsing HMS Scholarly Articles by Keyword "Biophysics Simulations"
Now showing items 1-3 of 3
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Development of Antipsychotic Medications with Novel Mechanisms of Action Based on Computational Modeling of Hippocampal Neuropathology
(Public Library of Science, 2013)A large number of cellular level abnormalities have been identified in the hippocampus of schizophrenic subjects. Nonetheless, it remains uncertain how these pathologies interact at a system level to create clinical symptoms, ... -
Mechanical Stretch and PI3K Signaling Link Cell Migration and Proliferation to Coordinate Epithelial Tubule Morphogenesis in the Zebrafish Pronephros
(Public Library of Science, 2012)Organ development leads to the emergence of organ function, which in turn can impact developmental processes. Here we show that fluid flow-induced collective epithelial migration during kidney nephron morphogenesis induces ... -
Point Charges Optimally Placed to Represent the Multipole Expansion of Charge Distributions
(Public Library of Science, 2013)We propose an approach for approximating electrostatic charge distributions with a small number of point charges to optimally represent the original charge distribution. By construction, the proposed optimal point charge ...