Browsing HMS Scholarly Articles by Keyword "Cancer"

Now showing items 1-20 of 32

    • Bioluminescence-Activated Deep-Tissue Photodynamic Therapy of Cancer 

      Kim, Yi Rang; Kim, Seonghoon; Choi, Jin Woo; Choi, Sung Yong; Lee, Sang-Hee; Kim, Homin; Hahn, Sei Kwang; Koh, Gou Young; Yun, Seok Hyun (Ivyspring International Publisher, 2015)
      Optical energy can trigger a variety of photochemical processes useful for therapies. Owing to the shallow penetration of light in tissues, however, the clinical applications of light-activated therapies have been limited. ...

    • Broad targeting of angiogenesis for cancer prevention and therapy 

      Wang, Zongwei; Dabrosin, Charlotta; Yin, Xin; Fuster, Mark M.; Arreola, Alexandra; Rathmell, W. Kimryn; Generali, Daniele; Nagaraju, Ganji P.; El-Rayes, Bassel; Ribatti, Domenico; Chen, Yi Charlie; Honoki, Kanya; Fujii, Hiromasa; Georgakilas, Alexandros G.; Nowsheen, Somaira; Amedei, Amedeo; Niccolai, Elena; Amin, Amr; Ashraf, S. Salman; Helferich, Bill; Yang, Xujuan; Guha, Gunjan; Bhakta, Dipita; Ciriolo, Maria Rosa; Aquilano, Katia; Chen, Sophie; Halicka, Dorota; Mohammed, Sulma I.; Azmi, Asfar S.; Bilsland, Alan; Keith, W. Nicol; Jensen, Lasse D. (Academic Press, 2015)
      Deregulation of angiogenesis – the growth of new blood vessels from an existing vasculature – is a main driving force in many severe human diseases including cancer. As such, tumor angiogenesis is important for delivering ...

    • Cancer Nanomedicine: From Targeted Delivery to Combination Therapy 

      Xu, Xiaoyang; Ho, William; Zhang, Xueqing; Bertrand, Nicolas; Farokhzad, Omid (2015)
      The advent of nanomedicine marks an unparalleled opportunity to advance the treatment of a variety of diseases, including cancer. The unique properties of nanoparticles, such as large surface-to volume ratio, small size, ...

    • Combination immunotherapy: Where do we go from here? 

      Overacre, Abigail E.; Kurtulus, Sema; Sznol, Mario; Pardoll, Drew M.; Anderson, Ana; Vignali, Dario A. A. (BioMed Central, 2015)
      The remarkable clinical success of cancer immunotherapies targeting the checkpoint receptors CTLA-4 and PD-1 has generated considerable excitement and emboldened efforts to build on this important foundation. Research ...

    • A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma 

      Chan, Tim Hon Man; Lin, Chi Ho; Qi, Lihua; Fei, Jing; Li, Yan; Yong, Kol Jia; Liu, Ming; Song, Yangyang; Chow, Raymond Kwok Kei; Ng, Vanessa Hui En; Yuan, Yun-Fei; Tenen, Daniel G; Guan, Xin-Yuan; Chen, Leilei (BMJ Publishing Group, 2014)
      Objective: Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional modifications, such as alternative splicing ...

    • The electronic self report assessment and intervention for cancer: promoting patient verbal reporting of symptom and quality of life issues in a randomized controlled trial 

      Berry, Donna L; Hong, Fangxin; Halpenny, Barbara; Partridge, Anne; Fox, Erica; Fann, Jesse R; Wolpin, Seth; Lober, William B; Bush, Nigel; Parvathaneni, Upendra; Amtmann, Dagmar; Ford, Rosemary (BioMed Central, 2014)
      Background: The electronic self report assessment - cancer (ESRA-C), has been shown to reduce symptom distress during cancer therapy The purpose of this analysis was to evaluate aspects of how the ESRA-C intervention may ...

    • Estimated effective dose of CT-guided percutaneous cryoablation of liver tumors 

      Park, Byung Kwan; Morrison, Paul T; Tatli, Servet; Govindarajulu, Usha; Tuncali, Kemal; Judy, Philip Frank; Shyn, Paul B.; Silverman, Stuart George (Elsevier BV, 2012)
      Purpose: To estimate effective dose during CT-guided cryoablation of liver tumors, and to assess which procedural factors contribute most to dose. Materials and methods: Our institutional review board approved this ...

    • The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis 

      Gibson, William J.; Hoivik, Erling A.; Halle, Mari K.; Taylor-Weiner, Amaro; Cherniack, Andrew D.; Berg, Anna; Holst, Frederik; Zack, Travis I.; Werner, Henrica M. J.; Staby, Kjersti M.; Rosenberg, Mara; Stefansson, Ingunn M.; Kusonmano, Kanthida; Chevalier, Aaron; Mauland, Karen K.; Trovik, Jone; Krakstad, Camilla; Giannakis, Marios; Hodis, Eran; Woie, Kathrine; Bjorge, Line; Vintermyr, Olav K.; Wala, Jeremiah A.; Lawrence, Michael S.; Getz, Gad; Carter, Scott L.; Beroukhim, Rameen; Salvesen, Helga B. (2016)
      Recent studies have detailed the genomic landscape of primary endometrial cancers, but their evolution into metastases has not been characterized. We performed whole-exome sequencing of 98 tumor biopsies including complex ...

    • Heterogeneity in Host Risk Factors for Incident Melanoma and Non-Melanoma Skin Cancer in a Cohort of US Women 

      Qureshi, Abrar A.; Zhang, Mingfeng; Han, Jiali (Japan Epidemiological Association, 2011)
      Background: Melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) are 3 types of skin cancer that have distinct biologic characteristics and prognoses. We evaluated phenotypic differences in the risk of ...

    • A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods 

      Yarrow, Justin C; Perlman, Zachary E; Westwood, Nicholas J; Mitchison, Timothy J. (BioMed Central, 2004)
      Background: Cell migration is a complex phenomenon that requires the coordination of numerous cellular processes. Investigation of cell migration and its underlying biology is of interest to basic scientists and those in ...

    • Identification of Associations Between Prescribed Medications and Cancer: A Nationwide Screening Study 

      Pottegård, Anton; Friis, Søren; Christensen, René dePont; Habel, Laurel A.; Gagne, Joshua J.; Hallas, Jesper (Elsevier, 2016)
      Purpose We present a systematic screening for identifying associations between prescribed drugs and cancer risk using the high quality Danish nationwide health registries. Methods: We identified all patients (cases) with ...

    • In vitro models of cancer stem cells and clinical applications 

      S. Franco, Sara; Szczesna, Karolina; Iliou, Maria S.; Al-Qahtani, Mohammed; Mobasheri, Ali; Kobolák, Julianna; Dinnyés, András (BioMed Central, 2016)
      Cancer cells, stem cells and cancer stem cells have for a long time played a significant role in the biomedical sciences. Though cancer therapy is more effective than it was a few years ago, the truth is that still none ...

    • An information model for computable cancer phenotypes 

      Hochheiser, Harry; Castine, Melissa; Harris, David; Savova, Guergana; Jacobson, Rebecca S. (BioMed Central, 2016)
      Background: Standards, methods, and tools supporting the integration of clinical data and genomic information are an area of significant need and rapid growth in biomedical informatics. Integration of cancer clinical data ...

    • Integrating transcriptional and protein interaction networks to prioritize condition-specific master regulators 

      Padi, Megha; Quackenbush, John (BioMed Central, 2015)
      Background: Genome-wide libraries of yeast deletion strains have been used to screen for genes that drive phenotypes such as stress response. A surprising observation emerging from these studies is that the genes with the ...

    • Involvement of low- and middle-income countries in randomized controlled trial publications in oncology 

      Wong, Janice C; Fernandes, Kimberly A; Amin, Shubarna; Lwin, Zarnie; Krzyzanowska, Monika K (BioMed Central, 2014)
      Background: We describe trends in participation by investigators from low- and middle-income countries (LMCs) in publications describing oncology randomized control trials (RCTs) over a decade. Methods: We used Medline to ...

    • Is DNA methylation of tumour suppressor genes epigenetic? 

      Struhl, Kevin (eLife Sciences Publications, Ltd, 2014)
      In colorectal cancer cells, a non-epigenetic transcriptional pathway that is mediated by an oncogene maintains DNA methylation of tumour suppressor genes

    • Longitudinal trends in use and costs of targeted therapies for common cancers in Taiwan: a retrospective observational study 

      Hsu, Jason C; Lu, Christine Y (BMJ Publishing Group, 2016)
      Objectives: Some targeted therapies have improved survival and overall quality of cancer care generally, but these increasingly expensive medicines have led to increases in pharmaceutical expenditure. This study examined ...

    • Mediterranean Diet and Workplace Health Promotion 

      Korre, Maria; Tsoukas, Michael A.; Frantzeskou, Elpida; Yang, Justin; Kales, Stefanos N. (Springer US, 2014)
      Analytical and experimental studies confirm relationships between the consumption of certain foods and cardiovascular disease, diabetes, and cancer. Mediterranean diet patterns have long been associated with a reduced risk ...

    • Neutrophil extracellular traps 

      Demers, Mélanie; Wagner, Denisa D. (Landes Bioscience, 2013)
      Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) ...

    • Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies 

      Aune, Dagfinn; Keum, NaNa; Giovannucci, Edward; Fadnes, Lars T.; Boffetta, Paolo; Greenwood, Darren C.; Tonstad, Serena; Vatten, Lars J.; Riboli, Elio; Norat, Teresa (BioMed Central, 2016)
      Background: Although nut consumption has been associated with a reduced risk of cardiovascular disease and all-cause mortality, data on less common causes of death has not been systematically assessed. Previous reviews ...