Browsing HMS Scholarly Articles by Keyword "Cancer genomics"
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3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
(BioMed Central, 2017)Many mutations in cancer are of unknown functional significance. Standard methods use statistically significant recurrence of mutations in tumor samples as an indicator of functional impact. We extend such analyses into ... -
The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis
(2016)Recent studies have detailed the genomic landscape of primary endometrial cancers, but their evolution into metastases has not been characterized. We performed whole-exome sequencing of 98 tumor biopsies including complex ... -
TumorTracer: a method to identify the tissue of origin from the somatic mutations of a tumor specimen
(BioMed Central, 2015)Background: A substantial proportion of cancer cases present with a metastatic tumor and require further testing to determine the primary site; many of these are never fully diagnosed and remain cancer of unknown primary ...