Browsing HMS Scholarly Articles by Keyword "Central Nervous System"

Now showing items 1-18 of 18

    • APOE Status Modulates the Changes in Network Connectivity Induced by Brain Stimulation in Non-Demented Elders 

      Peña-Gomez, Cleofé; Solé-Padullés, Cristina; Clemente, Imma C.; Junqué, Carme; Bargalló, Núria; Bosch, Beatriz; Molinuevo, José Luis; Valls-Solé, Josep; Pascual-Leone, Alvaro; Bartrés-Faz, David (Public Library of Science, 2012)
      Behavioral consequences of a brain insult represent an interaction between the injury and the capacity of the rest of the brain to adapt to it. We provide experimental support for the notion that genetic factors play a ...

    • Ca\(^{2+}\)/Calmodulin-Dependent Protein Kinase Kinase Is Not Involved in Hypothalamic AMP-Activated Protein Kinase Activation by Neuroglucopenia 

      Kawashima, Junji; Alquier, Thierry; Tsuji, Youki; Peroni, Odile Daniele; Kahn, Barbara (Public Library of Science, 2012)
      Hypoglycemia and neuroglucopenia stimulate AMP-activated protein kinase (AMPK) activity in the hypothalamus and this plays an important role in the counterregulatory responses, i.e. increased food intake and secretion of ...

    • Decreased Brain Neurokinin-1 Receptor Availability in Chronic Tennis Elbow 

      Linnman, Clas; Catana, Ciprian; Svärdsudd, Kurt; Appel, Lieuwe; Engler, Henry; Långström, Bengt; Sörensen, Jens; Furmark, Tomas; Fredrikson, Mats; Borsook, David; Peterson, Magnus (Public Library of Science, 2016)
      Substance P is released in painful and inflammatory conditions, affecting both peripheral processes and the central nervous system neurokinin 1 (NK1) receptor. There is a paucity of data on human brain alterations in NK1 ...

    • Development of Antipsychotic Medications with Novel Mechanisms of Action Based on Computational Modeling of Hippocampal Neuropathology 

      Siekmeier, Peter J.; van Maanen, David P (Public Library of Science, 2013)
      A large number of cellular level abnormalities have been identified in the hippocampus of schizophrenic subjects. Nonetheless, it remains uncertain how these pathologies interact at a system level to create clinical symptoms, ...

    • Diffusion Tensor Imaging in Patients with Glioblastoma Multiforme Using the Supertoroidal Model 

      Mekkaoui, Choukri; Metellus, Philippe; Kostis, William J.; Martuzzi, Roberto; Pereira, Fabricio R.; Beregi, Jean-Paul; Reese, Timothy G.; Constable, Todd R.; Jackowski, Marcel P. (Public Library of Science, 2016)
      Purpose Diffusion Tensor Imaging (DTI) is a powerful imaging technique that has led to improvements in the diagnosis and prognosis of cerebral lesions and neurosurgical guidance for tumor resection. Traditional tensor ...

    • Dissociable Influences of Auditory Object vs. Spatial Attention on Visual System Oscillatory Activity 

      Ahveninen, Jyrki Pekka; Jääskeläinen, Iiro P.; Belliveau, John William; Hämäläinen, Matti; Lin, Fa-Hsuan; Raij, Tommi A. (Public Library of Science, 2012)
      Given that both auditory and visual systems have anatomically separate object identification (“what”) and spatial (“where”) pathways, it is of interest whether attention-driven cross-sensory modulations occur separately ...

    • Effects of Sensory Behavioral Tasks on Pain Threshold and Cortical Excitability 

      Volz, Magdalena Sarah; Suarez-Contreras, Vanessa; Mendonca, Mariana E.; Pinheiro, Fernando Santos; Merabet, Lotfi B.; Fregni, Felipe (Public Library of Science, 2013)
      Background/objective: Transcutaneous electrical stimulation has been proven to modulate nervous system activity, leading to changes in pain perception, via the peripheral sensory system, in a bottom up approach. We tested ...

    • Increased Gray Matter Diffusion Anisotropy in Patients with Persistent Post-Concussive Symptoms following Mild Traumatic Brain Injury 

      Bouix, Sylvain; Pasternak, Ofer; Rathi, Yogesh; Pelavin, Paula E.; Zafonte, Ross; Shenton, Martha E. (Public Library of Science, 2013)
      A significant percentage of individuals diagnosed with mild traumatic brain injury (mTBI) experience persistent post-concussive symptoms (PPCS). Little is known about the pathology of these symptoms and there is often no ...

    • The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway 

      Talos, Delia Maria; Sun, Hongyu; Zhou, Xiangping; Fitzgerald, Erin C.; Jackson, Michele C.; Klein, Peter M.; Lan, Victor J.; Joseph, Annelise; Jensen, Frances Elizabeth (Public Library of Science, 2012)
      Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes such as autism, and conversely epilepsy is common in autistic children. We hypothesized that during early brain development, ...

    • JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection 

      Wharton, Keith A.; Quigley, Catherine; Themeles, Marian; Dunstan, Robert W.; Doyle, Kathryn; Cahir-McFarland, Ellen; Wei, Jing; Buko, Alex; Reid, Carl E.; Sun, Chao; Carmillo, Paul; Sur, Gargi; Carulli, John P.; Mansfield, Keith G.; Westmoreland, Susan V.; Staugaitis, Susan M.; Fox, Robert J.; Meier, Werner; Goelz, Susan E. (Public Library of Science, 2016)
      Over half of adults are seropositive for JC polyomavirus (JCV), but rare individuals develop progressive multifocal leukoencephalopathy (PML), a demyelinating JCV infection of the central nervous system. Previously, PML ...

    • Longitudinal Changes in White Matter Tract Integrity across the Adult Lifespan and Its Relation to Cortical Thinning 

      Storsve, Andreas B.; Fjell, Anders M.; Yendiki, Anastasia; Walhovd, Kristine B. (Public Library of Science, 2016)
      A causal link between decreases in white matter (WM) integrity and cortical degeneration is assumed, but there is scarce knowledge on the relationship between these changes across the adult human lifespan. We investigated ...

    • Modeling Intracerebral Hemorrhage Growth and Response to Anticoagulation 

      Greenberg, Charles H.; Frosch, Matthew P.; Goldstein, Joshua Norkin; Rosand, Jonathan; Greenberg, Steven Mark (Public Library of Science, 2012)
      The mechanism for hemorrhage enlargement in the brain, a key determinant of patient outcome following hemorrhagic stroke, is unknown. We performed computer-based stochastic simulation of one proposed mechanism, in which ...

    • Prolonged High Fat Diet Reduces Dopamine Reuptake without Altering DAT Gene Expression 

      Cone, Jackson J.; Chartoff, Elena Halley; Potter, David N.; Ebner, Stephanie R.; Roitman, Mitchell F. (Public Library of Science, 2013)
      The development of diet-induced obesity (DIO) can potently alter multiple aspects of dopamine signaling, including dopamine transporter (DAT) expression and dopamine reuptake. However, the time-course of diet-induced changes ...

    • Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group 

      Su, Yi; Blazey, Tyler M.; Owen, Christopher J.; Christensen, Jon J.; Friedrichsen, Karl; Joseph-Mathurin, Nelly; Wang, Qing; Hornbeck, Russ C.; Ances, Beau M.; Snyder, Abraham Z.; Cash, Lisa A.; Koeppe, Robert A.; Klunk, William E.; Galasko, Douglas; Brickman, Adam M.; McDade, Eric; Ringman, John M.; Thompson, Paul M.; Saykin, Andrew J.; Ghetti, Bernardino; Sperling, Reisa A.; Johnson, Keith A.; Salloway, Stephen P.; Schofield, Peter R.; Masters, Colin L.; Villemagne, Victor L.; Fox, Nick C.; Förster, Stefan; Chen, Kewei; Reiman, Eric M.; Xiong, Chengjie; Marcus, Daniel S.; Weiner, Michael W.; Morris, John C.; Bateman, Randall J.; Benzinger, Tammie L. S. (Public Library of Science, 2016)
      Amyloid imaging plays an important role in the research and diagnosis of dementing disorders. Substantial variation in quantitative methods to measure brain amyloid burden exists in the field. The aim of this work is to ...

    • Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function 

      Suzuki, Ryo; Ferris, Heather; Chee, Melissa; Maratos-Flier, Eleftheria; Kahn, C. Ronald (Public Library of Science, 2013)
      The sterol sensor SCAP is a key regulator of SREBP-2, the major transcription factor controlling cholesterol synthesis. Recently, we showed that there is a global down-regulation of cholesterol synthetic genes, as well as ...

    • Thalamic Volume Is Reduced in Cervical and Laryngeal Dystonias 

      Waugh, Jeff L.; Kuster, John K.; Levenstein, Jacob M.; Makris, Nikos; Multhaupt-Buell, Trisha J.; Sudarsky, Lewis R.; Breiter, Hans C.; Sharma, Nutan; Blood, Anne J. (Public Library of Science, 2016)
      Background: Dystonia, a debilitating movement disorder characterized by abnormal fixed positions and/or twisting postures, is associated with dysfunction of motor control networks. While gross brain lesions can produce ...

    • The V‐ATPase is expressed in the choroid plexus and mediates cAMP‐induced intracellular pH alterations 

      Christensen, Henriette L.; Păunescu, Teodor G.; Matchkov, Vladimir; Barbuskaite, Dagne; Brown, Dennis; Damkier, Helle H.; Praetorius, Jeppe (John Wiley and Sons Inc., 2017)
      Abstract The cerebrospinal fluid (CSF) pH influences brain interstitial pH and, therefore, brain function. We hypothesized that the choroid plexus epithelium (CPE) expresses the vacuolar H+‐ATPase (V‐ATPase) as an acid ...

    • Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome 

      Klase, Zachary A.; Khakhina, Svetlana; Schneider, Adriano De Bernardi; Callahan, Michael V.; Glasspool-Malone, Jill; Malone, Robert (Public Library of Science, 2016)
      The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain–Barré syndrome) has brought attention to this ...